ID A4HH23_LEIBR Unreviewed; 692 AA.
AC A4HH23;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 13-SEP-2023, entry version 84.
DE RecName: Full=Intraflagellar transport protein B2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=LBRM_29_0160 {ECO:0000313|EMBL:CAM39872.2};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM39872.2, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM39872.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39872.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM39872.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39872.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138}.
CC -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family.
CC {ECO:0000256|ARBA:ARBA00009522}.
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DR EMBL; FR799004; CAM39872.2; -; Genomic_DNA.
DR RefSeq; XP_001566364.2; XM_001566314.2.
DR AlphaFoldDB; A4HH23; -.
DR STRING; 5660.A4HH23; -.
DR GeneID; 5417248; -.
DR KEGG; lbz:LBRM_29_0160; -.
DR VEuPathDB; TriTrypDB:LbrM.29.0160; -.
DR VEuPathDB; TriTrypDB:LBRM2903_290006900; -.
DR InParanoid; A4HH23; -.
DR Proteomes; UP000007258; Chromosome 29.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039941; TT30.
DR PANTHER; PTHR20931:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 30; 1.
DR PANTHER; PTHR20931; UNCHARACTERIZED; 1.
DR Pfam; PF12895; ANAPC3; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 2.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 78827 MW; 7DA91A9783B411CD CRC64;
MSVRPITGMR PPTTGTAFSA TGSSHTGSVR PTTTMGGGTT LGRIQAQVQE GTFTSTVYGY
IRDHQYEEAV ELLATQLEEF PRSRAAVSLM AYCYYMMGDY GEAASLYEQL TKICPSIEEY
RVYYAQSLYK AGAYAESNRL CTVITSPQNQ IAVNKLQAAI AYEQEDIPQT KSFLEQAPST
DTDMLVLRAC VLSKEGSHEE ALEKFKEAQS TIGFSAALTY NMALMYYKME QYGPALRHLA
EIIDRGVEGH PELNIGTNTE GGEARSVGNT QLLRDTALIE AFNLKAAIEY VSKNMQASKE
ALTDMPPRTD EELDPVTLHN TALINMDENP TNAFKKFNFL LQNPPFPPET FQNLLLFYCK
YQYYDLAADV LAENPHLAWQ YLSQNNQSLY DFLDGLITAQ TSPAEAYRKF DVLAQKMVQQ
LRHLTRRIQE ADQSQDAAVA RMAVRTYDVT LEEYIPVLMA QANIYWEMEN YPMVEQLFRQ
SADFCSENDV WKQNVAHVFF MQETKFKEAI RYYLPVVEAN RDSILSCSAI VLANLCVSYI
MTAQNEQAEE IMRRIERAEE RLTYEDPSKQ PLHLCIVNLV IGTLYCSKGN FEFGISRIIK
SLEPYDRKIM TDTWFYAKRC FLALAMNLAK HMVALKDSSF EEILFFFDQA DLHGEKVFAF
VHPDPSKQDT SPRNTVRWEA RQLKKLYLTL KE
//
