ID A4HIG8_LEIBR Unreviewed; 546 AA.
AC A4HIG8;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Conserved zinc-finger protein {ECO:0000313|EMBL:CAM40380.1};
GN ORFNames=LBRM_30_2310 {ECO:0000313|EMBL:CAM40380.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM40380.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM40380.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40380.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM40380.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40380.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FR799005; CAM40380.1; -; Genomic_DNA.
DR RefSeq; XP_001566858.1; XM_001566808.1.
DR AlphaFoldDB; A4HIG8; -.
DR STRING; 5660.A4HIG8; -.
DR GeneID; 5417756; -.
DR KEGG; lbz:LBRM_30_2310; -.
DR VEuPathDB; TriTrypDB:LbrM.30.2310; -.
DR VEuPathDB; TriTrypDB:LBRM2903_300029500; -.
DR InParanoid; A4HIG8; -.
DR OMA; CGICFNV; -.
DR Proteomes; UP000007258; Chromosome 30.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19757; Bbox1; 1.
DR CDD; cd19756; Bbox2; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047153; TRIM45/56/19.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25462:SF302; B BOX-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR25462; BONUS, ISOFORM C-RELATED; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR SMART; SM00184; RING; 2.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 8..49
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 86..127
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 133..177
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT COILED 185..212
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 546 AA; 61006 MW; 917ED75123555A84 CRC64;
MSARVITCGI CFNVLNQPLT LECNHSFCAK CIRIRLAESG NSGLQCPLCG TSHTELHSHN
LAQYADHEAE VYVEMLSRDM PDPPTCQWCE TTTAKVQCGE CRCVYCEECS IAVHRNSAKR
DHAIGKLSES SRNFMRRCQL RGHEEYRAEF FCSQCRQICC AYCLQVGPHR DHLHVTVAAA
AAEARQQLSR DMQSLVEVKH RLEQQAAEMN RVSVLYTDTY DAVENTVTER FETFKQQLMQ
RELEVRRTLT KLRDSGDATL TASRQQYLDK LNNINATLLQ FRSIQNGGTD DEVLQRHSQL
GNCLNTDLPA VTGSGFKVVD LGEMTLTSLG IDLDLQTVEH NQHILPRLNR SARLKDASKM
SINSGASVFS FAGNLLSLPL RLTFPVDDDV EATVLAEGVR LRCVARGGGA TQIGVRSKEM
FRTLLGQFPE DRGVVSWQVR LDSISDSFIG VVERPSQAAQ VPEGFYWKPT CAGVTDGRIG
RYTTAVRHLP VCRNGDHVRF VYDGDEGSLR VIINDRDDCG VVVADLHPRI AACFIFYPSE
SLTVLF
//
