ID A4HIH8_LEIBR Unreviewed; 651 AA.
AC A4HIH8;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Putative heat shock 70-related protein 1,mitochondrial {ECO:0000313|EMBL:CAM40391.1};
GN ORFNames=LBRM_30_2420 {ECO:0000313|EMBL:CAM40391.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM40391.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM40391.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40391.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM40391.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40391.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|RuleBase:RU003322}.
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DR EMBL; FR799005; CAM40391.1; -; Genomic_DNA.
DR RefSeq; XP_001566868.1; XM_001566818.1.
DR AlphaFoldDB; A4HIH8; -.
DR STRING; 5660.A4HIH8; -.
DR GeneID; 5417767; -.
DR KEGG; lbz:LBRM_30_2420; -.
DR VEuPathDB; TriTrypDB:LbrM.30.2440; -.
DR VEuPathDB; TriTrypDB:LBRM2903_300031400; -.
DR InParanoid; A4HIH8; -.
DR OMA; GREQKMT; -.
DR Proteomes; UP000007258; Chromosome 30.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR HAMAP; MF_00332; DnaK; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR012725; Chaperone_DnaK.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR NCBIfam; TIGR02350; prok_dnaK; 1.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR PANTHER; PTHR19375:SF184; STRESS-70 PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Stress response {ECO:0000313|EMBL:CAM40391.1}.
FT REGION 625..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 272..299
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 651 AA; 70529 MW; ED9D34923F89DF59 CRC64;
MFARRVCGGA AVSAARLVRC ESQKVTGDVI GVDLGTTYSC VATMDGDKAR VLENSEGFRT
TPSVVAFKGS EKLVGLAAKR QAITNPQSTF YAVKRLIGRR FEDEHIQRDI KNVPYKIVRA
GNGDAWVQDG NGKQYSPSQV GAFVLEKMKE TAQNFLGHTV SNAVVTCPAY FNDAQRQATK
DAGTIAGLNV IRVVNEPTAA ALAYGMDKTK DSLIAVYDLG GGTFDISVLE IAGGVFEVKA
TNGDTHLGGE DFDLALSDYI LEEFRKTSGI DLSKERMALQ RVREAAEKAK CELSSAMETE
VNLPFITANA DGAQHIQMHI SRSKFEGITT RLIERSIAPC KQCIKDAGVE LKEINDVVLV
GGMTRMPKVV EEVKRFFQKE PFRGVNPDEA VALGAATLGG VLRGDVKGLV LLDVTPLSLG
IETLGGVFTR MIPKNTTIPT KKSQTFSTAA DNQTQVGIKV FQGEREMAAD NQMMGQFDLV
GIPPAPRGVP QVEVTFDIDA NGICHVTAKD KATGKTQNIT ITAHGGLSKE QIEQMVRDSE
QHAEADRVKR ELVEARNNAE TQLTTAERQL GEWKYVSDAE KENVKTHVAE LRKAMENPNV
AKDDLAAATD KLQKAVMECG RTEYQQAAAA NSGSSSNSGE QQQQQQSSEK N
//