ID A4HIN1_LEIBR Unreviewed; 408 AA.
AC A4HIN1;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=DUF2817 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LBRM_30_2960 {ECO:0000313|EMBL:CAM40445.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM40445.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM40445.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40445.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM40445.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40445.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799005; CAM40445.1; -; Genomic_DNA.
DR RefSeq; XP_001566921.1; XM_001566871.1.
DR AlphaFoldDB; A4HIN1; -.
DR GeneID; 5417821; -.
DR KEGG; lbz:LBRM_30_2960; -.
DR VEuPathDB; TriTrypDB:LbrM.30.2960; -.
DR VEuPathDB; TriTrypDB:LBRM2903_300036300; -.
DR InParanoid; A4HIN1; -.
DR OMA; NPYGFSH; -.
DR Proteomes; UP000007258; Chromosome 30.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd06233; M14-like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR021259; DUF2817.
DR Pfam; PF10994; DUF2817; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 408 AA; 45596 MW; B4367B9F88039ACD CRC64;
MAVPCDYVFS TLLVILTGLL FIDLVPLQET MRCSGDYANA TQCPEVYYSS SYQLARERFL
AAAKTAHAET EHHLITKRGN VEYYMDTAFF PGKRKAKLLV HTSGTHGVEG YTGSAIQVKL
LQEWNKTSLS GPSVLFVHAV NPHGMAHFRR FNEENVDLNR NYLSTEEWAA VKTRVANATG
YEDFRTLFVP SAPPRFIDRY VFLYTAAKTL MRHRFIKVKR AFVTGQYHDP VGINYGGEKE
QKSISVLRKV LKKHAAATGA TEAIYIDVHT GLGPTGVDTM MVKDGRDYEK CRTVFPGVRI
GNSQIATSGP SSGYDLAAGI IHPVAELGPN TLAVMEEFGT VNPLYVARAV VLENAAYQLC
RGSYTHTVMQ SWMRDAFYPQ EISFKHATLK RGSSAFWSAW TYLAENQR
//
