ID A4HLD0_LEIBR Unreviewed; 626 AA.
AC A4HLD0;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Putative histone deacetylase {ECO:0000313|EMBL:CAM40624.1};
GN ORFNames=LBRM_33_0940 {ECO:0000313|EMBL:CAM40624.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM40624.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM40624.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40624.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM40624.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM40624.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR799008; CAM40624.1; -; Genomic_DNA.
DR RefSeq; XP_001567864.1; XM_001567814.1.
DR AlphaFoldDB; A4HLD0; -.
DR STRING; 5660.A4HLD0; -.
DR GeneID; 5418797; -.
DR KEGG; lbz:LBRM_33_0940; -.
DR VEuPathDB; TriTrypDB:LbrM.33.0940; -.
DR VEuPathDB; TriTrypDB:LBRM2903_330014100; -.
DR InParanoid; A4HLD0; -.
DR OMA; NIPWPTH; -.
DR Proteomes; UP000007258; Chromosome 33.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd09992; HDAC_classII; 1.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 2.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF7; DEACETYLASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 2.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 118..304
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT DOMAIN 461..583
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
FT REGION 344..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..363
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 626 AA; 67137 MW; 2CEB61A11ED40965 CRC64;
MPKRQRSDEK VVHHAELSVE SGRRFDAYIR GWMQGTVESP LIRPSLLPPL TPLPTLAAWS
KSGVAPTPAT TSAGVAVSDL SYLCEWTPSS AVMPSLRTAV VYHMSMLDHV SPDAGEYERP
ARLQSTIDHL TAIGLLACCQ RIPARAAKTR ELRRVHSRKL VDTIDQLDFF MGIQEGRGGV
IGQDLFASEH TSRAARMAAG CVIEATNAVV SGAATNAFAL VRPPGHHAGP DNAAGFCLYN
NVAVAARAAQ AELMAAKTKS DPAGDAQQPR ILILDWDVHH CDGTESVFYD DPSVLVISVH
QYGNGPGHVL RKVSTVSAKQ PAEMPTADKE DVTAEDLAAL LSADAVEPPP VPLPEPPRDE
AAPAPAQTPT EGHRLRTEVD YNKLAVQMEE KDDTEIAALF GVDLNAASSS SSSSSSDLSS
SFDSTDGSSA PRNGRRSVHH PGDTVGLSVD ETPQNVTGAE EELFYPGTGH LNRVGGDATA
AAQGRNINIP WPTHGMGDLE YLQLLHEIVL PVAREFRPEL VLISSGFDSA SGDLLGSMCL
TPSGFYIMTR LMAQNFPRLV VALEGGYNLR NVALCSEAVM RALLESSGFP GDQLPKSRML
WCQASSLAAD IKRMHAPYWS CFSQNL
//
