ID A4HMX7_LEIBR Unreviewed; 860 AA.
AC A4HMX7;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Probable eukaryotic initiation factor 4A {ECO:0000256|ARBA:ARBA00024417};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE AltName: Full=ATP-dependent RNA helicase eIF4A {ECO:0000256|ARBA:ARBA00030297};
GN ORFNames=LBRM_34_3010 {ECO:0000313|EMBL:CAM43518.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM43518.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM43518.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM43518.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM43518.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM43518.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBUNIT: eIF4F is a multi-subunit complex, the composition of which
CC varies with external and internal environmental conditions. It is
CC composed of at least EIF4A, EIF4E and EIF4G.
CC {ECO:0000256|ARBA:ARBA00025917}.
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DR EMBL; FR799009; CAM43518.1; -; Genomic_DNA.
DR RefSeq; XP_001568407.1; XM_001568357.1.
DR AlphaFoldDB; A4HMX7; -.
DR SMR; A4HMX7; -.
DR STRING; 5660.A4HMX7; -.
DR GeneID; 5419361; -.
DR KEGG; lbz:LBRM_34_3010; -.
DR VEuPathDB; TriTrypDB:LbrM.34.3010; -.
DR VEuPathDB; TriTrypDB:LBRM2903_340038700; -.
DR InParanoid; A4HMX7; -.
DR OMA; NCHDEAK; -.
DR Proteomes; UP000007258; Chromosome 35.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47958; ATP-DEPENDENT RNA HELICASE DBP3; 1.
DR PANTHER; PTHR47958:SF40; EUKARYOTIC INITIATION FACTOR 4A-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:CAM43518.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 405..433
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 436..615
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 643..788
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 405..433
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 1..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..258
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 860 AA; 94393 MW; F8DA41B8B18073A0 CRC64;
MDYISDKKTS DTEYQRYGAV EGDEVSTFRD DRREYSRGGR GRRGGAHRSD NWRFDPSGGG
PNGDDSGEYR GGRGGYRGGR GGRGGGRGSR GSYNTWTNRE TRDEDNAIPA TSDVAGANTP
STTLTPTSAP AETGGVVAPA QESCEAPCEY GNREDDLGYS RGGRGGYRGG GRSYDSGYGG
RGGRGGRRYC DPEEEGEEGG YSQSYNSGYG GGGYRRGGYG GRGGRRYYDD EGDYAEGGDR
ACGRGYEDDD HDDGGSDPYR RSSAPWRRGN YGRDFDYDRP RGRGGRGGRR DFRSFRNEND
AMEESGAAQD NAWTSLPAPT EAPTVPRESP PAPAKAEEGV PSPAPQQTQS GIRRVTRASH
LRRNCHDEAK VMELFEHRHR QTGISLDNYD SIPVEMVPRD VKPVEDFADL LVEPALAANI
ERCGYKKPTP VQRYGIPVAL AGSDLMACAQ TGSGKTAAFL IPVVQYMLVH GVSPARQRKS
YPIALVLAPT RELAVQIFDE VRKLTFNTDI FYDVVYGGTR YPQRFEQDIL VACPGRLRDM
FNEEYLSFSA IKFLILDEAD RMLEMGFEEQ IEELVASRYT DMPTVDDRQT FMFSATFPQR
ILNLAKRYLR RKYYLLTVGR VGSTTKNITQ TIEHVPDNEK MDRLLQIIYG HEMSDMVLIF
VETKKMAEDV NRRLHREGIS STTIHGDRRQ QDREAALEDF KQKVTPILVA TDVASRGLDI
PDVAHVVQFD LPQEMDDYTH RIGRTGRAGN KGIATAFYNR NNRRLALDLH KYFSEHGQEI
PKWFQQEAEL VEGEALLSRD IGGGGRRRGG GGGGGGGGGH RSGGSGGRGG GGGGGSWGDS
RPSAPSGGGR RGCGMDDGGF
//
