ID A4HWI6_LEIIN Unreviewed; 473 AA.
AC A4HWI6; A0A2K4YQF4; A0A381MDZ6;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=inositol-phosphate phosphatase {ECO:0000256|ARBA:ARBA00013106};
DE EC=3.1.3.25 {ECO:0000256|ARBA:ARBA00013106};
GN ORFNames=LINJ_15_0940 {ECO:0000313|EMBL:CAM66814.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM66814.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM66814.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66814.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM66814.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM66814.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a myo-inositol phosphate + H2O = myo-inositol + phosphate;
CC Xref=Rhea:RHEA:24056, ChEBI:CHEBI:15377, ChEBI:CHEBI:17268,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:84139; EC=3.1.3.25;
CC Evidence={ECO:0000256|ARBA:ARBA00001033};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the inositol monophosphatase superfamily.
CC {ECO:0000256|ARBA:ARBA00009759}.
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DR EMBL; FR796447; CAM66814.1; -; Genomic_DNA.
DR RefSeq; XP_001464427.1; XM_001464390.1.
DR AlphaFoldDB; A4HWI6; -.
DR STRING; 5671.A4HWI6; -.
DR GeneID; 5067820; -.
DR KEGG; lif:LINJ_15_0940; -.
DR VEuPathDB; TriTrypDB:LINF_150016900; -.
DR eggNOG; KOG2951; Eukaryota.
DR InParanoid; A4HWI6; -.
DR OMA; PDCCISI; -.
DR OrthoDB; 151755at2759; -.
DR Proteomes; UP000008153; Chromosome 15.
DR GO; GO:0008934; F:inositol monophosphate 1-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0052832; F:inositol monophosphate 3-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0052833; F:inositol monophosphate 4-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.190.80; -; 1.
DR Gene3D; 3.30.540.10; Fructose-1,6-Bisphosphatase, subunit A, domain 1; 1.
DR InterPro; IPR000760; Inositol_monophosphatase-like.
DR InterPro; IPR020550; Inositol_monophosphatase_CS.
DR PANTHER; PTHR20854; INOSITOL MONOPHOSPHATASE; 1.
DR PANTHER; PTHR20854:SF4; INOSITOL-1-MONOPHOSPHATASE-RELATED; 1.
DR Pfam; PF00459; Inositol_P; 2.
DR PRINTS; PR00377; IMPHPHTASES.
DR SUPFAM; SSF56655; Carbohydrate phosphatase; 2.
DR PROSITE; PS00630; IMP_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:CAM66814.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ SEQUENCE 473 AA; 49784 MW; E77DDDB9F0DB36C3 CRC64;
MSISVMSTPV PASSSADTGD MSLIEALGVA IEAADKGSRI IWQCVEKRRL AMAAAATFHT
TSALAAGGAA SVECENKTSA TNLVTQHSKQ CRETIIRILR QYSEEVQREK PHLRFAFLTE
ELNPGTPLSD DYTWVVDPID GAASFVHGLP DCCISIGLTY RKQPVLAVVF TPFISSGVRL
TVAAAAVLNV AQQQQQQQYQ HQQQQLVMSP TLSVTAPAIS GTMCGSVAAA PLTPMDVSKT
KMLDEHGTAA APTTALPPTP PTPPFPSLRA AAAATAAASA SPHSVPIITH TTPSVVPECN
GELFTAIKGF GAFVNGRQVR VNAKVVPATS VVVFNHPCGV MLSTAEAASP DGAAIRRRKC
DAAIDCSMAM RKELLRLPVA ALRCYGSCAA TLAQVAAGRV DAYLEPAGKA WDVCAGSLLV
TEAGGVVCNM LGRPLDMAHD TTIVAAATQE MADLMTEKCV RHGFGQYWLV EKE
//
