ID A4HYI3_LEIIN Unreviewed; 865 AA.
AC A4HYI3; A0A2K4YSM9; A0A381MGF7;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Choline/Carnitine o-acyltransferase-like protein {ECO:0000313|EMBL:CAM67367.1};
GN ORFNames=LINJ_19_1570 {ECO:0000313|EMBL:CAM67367.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM67367.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM67367.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM67367.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM67367.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM67367.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
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DR EMBL; FR796451; CAM67367.1; -; Genomic_DNA.
DR RefSeq; XP_001465124.1; XM_001465087.1.
DR AlphaFoldDB; A4HYI3; -.
DR SMR; A4HYI3; -.
DR STRING; 5671.A4HYI3; -.
DR GeneID; 5068535; -.
DR KEGG; lif:LINJ_19_1570; -.
DR VEuPathDB; TriTrypDB:LINF_190021800; -.
DR eggNOG; KOG3716; Eukaryota.
DR InParanoid; A4HYI3; -.
DR OMA; NTEHSWG; -.
DR OrthoDB; 1429709at2759; -.
DR Proteomes; UP000008153; Chromosome 19.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF31; CARNITINE O-PALMITOYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 195..845
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 537
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 865 AA; 97126 MW; 26D47E6DE8445CB1 CRC64;
MAEAFLSQRP HPANQTRDAG SSVMQMRVSW TCNGLDIHVP PLRYIWRGVH RSIVDNIDKV
SAMVYPIPFS CVVACAAGSC VCVWYVPQTS WVHTNPASTW LRYFDSIVTP LSRYLPPSFQ
APVLCAKAWA VTLAAATVLH RFALRRLLQY KGWMLERNPQ KPSWRTRVWS LVMRAFFTRP
SIPKTRVYGS CLPSVPLPSL QQTVSSYLSS MRSLYHQKDS DVNEWLELRR SAESFLLNEG
PSLQMYLRLQ NVMGHSYVPE LWTRNVFLAA RDSLCLHSNF YTVPFATHLP TPLPEARAAV
LIYLMTRLKG HIERRTLCPN FIGPRDCVPL SMDQYSMAFN TTRIPGREVD VLEHRGEREN
SYLVILHRGR IYQMPVIDPQ TGRQLTPHQL EVVLHQLLLE VEEEVSTGRD ESEEDDAEDT
LETLGKKRSY RVVEALLPAL TTASRAQWAD VRTSYLLHDS NNNGPLRIIE KALFVVSFDE
RCGMAVPSKA SSAVDEVKRL SMDCAHYLCG NGSNLWCDKS FNLVVRSDGH VGLHVEHSWS
DMSTFLGFFE HVSAQEESAD LWYDTESGHA KKLPEDKRRA KPFRAPNIDN PLCPKRLRFT
IHKKLAAAIR RAHTEFLLNT SSQVDLHVVR YSEYGREVPK SMGCSPDAWV QMAIQLAHYI
DQGGHFSLVY ESVPQRMFAK GRTEAVRSVT DVSSTFVKAM ASTGGEDEAM SAEEKRALLI
DACANHQRAV QEAVAGGGVD RHLFALFMAS ASQETPSDFL TAALRKTKWK VSSAQAHQRN
LLDRLHPAGG GSCYHETPGF GFGPVSPDGY GISYCFCANE VLYVTITSYK NCDATSSRTL
GNHMTRALDM LGALSASGRD DSAPR
//
