ID A4HZT6_LEIIN Unreviewed; 492 AA.
AC A4HZT6;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=TsaA-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LINJ_22_0460 {ECO:0000313|EMBL:CAM68000.2};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM68000.2, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM68000.2, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM68000.2,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM68000.2, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM68000.2,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the tRNA methyltransferase O family.
CC {ECO:0000256|ARBA:ARBA00033753}.
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DR EMBL; FR796454; CAM68000.2; -; Genomic_DNA.
DR RefSeq; XP_001465577.2; XM_001465540.2.
DR STRING; 5671.A4HZT6; -.
DR GeneID; 5068997; -.
DR KEGG; lif:LINJ_22_0460; -.
DR VEuPathDB; TriTrypDB:LINF_220011300; -.
DR eggNOG; KOG2942; Eukaryota.
DR InParanoid; A4HZT6; -.
DR Proteomes; UP000008153; Chromosome 22.
DR CDD; cd05162; PWWP; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.30.70; YaeB-like; 2.
DR InterPro; IPR000313; PWWP_dom.
DR InterPro; IPR023370; TrmO-like_N.
DR InterPro; IPR023368; UPF0066_cons_site.
DR InterPro; IPR040372; YaeB-like.
DR InterPro; IPR036413; YaeB-like_sf.
DR InterPro; IPR036414; YaeB_N_sf.
DR PANTHER; PTHR12818:SF0; TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12818; UNCHARACTERIZED; 1.
DR Pfam; PF01980; TrmO; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR SUPFAM; SSF118196; YaeB-like; 2.
DR PROSITE; PS50812; PWWP; 1.
DR PROSITE; PS01318; TSAA_1; 1.
DR PROSITE; PS51668; TSAA_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 59..78
FT /note="PWWP"
FT /evidence="ECO:0000259|PROSITE:PS50812"
FT DOMAIN 245..458
FT /note="TsaA-like"
FT /evidence="ECO:0000259|PROSITE:PS51668"
FT REGION 130..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 53424 MW; AC557F910F90F7A0 CRC64;
MSATPLSPSL QTALTSVSPT TLATPADTVA GATAPAAERV VRDGVSKKRY RVRANYFLVG
DLVWVRPAKL PYWPAEVVDC DEAANRVRAR LIVPPPAAVL AANLAEEQRK HRERRRREEA
RLFKMHKKEC KPASSTPTGN EVPSVHGHSS PLGLGVDSGT LSASCGAAPA PPEPQSDVVT
ANGKVVYFFD KLRTTEELDV CLESRLQRNK HDVTLYADAF TQAVLQANRL ARISLSPEKL
QPYEVCAVGI VHSLMRAHIE APRQPNTGTF EPQTGLIRLR TGLENAARDL AGFEFIWVLX
QFSFAAPMAS GEGQESVRKF REAREASASA TAGPASAVPD SVPATTEKAS PTADGHVDAC
HDSDGEALSA WALSSFRRRQ GFDRAAGFKT MIIPPRDEEW RGVFATRSPH RPNFIGLSCV
RLVAVHGLDI HIADHDLLHG TPVLDIKPYL PFCDAHADAR AGWVEALDAS GKGKGDHKYD
TQTTQVHRVT LE
//
