ID A4I076_LEIIN Unreviewed; 352 AA.
AC A4I076; A0A2K4YUI0; A0A381MHU1;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Putative NADP-dependent alcohol dehydrogenase {ECO:0000313|EMBL:CAM68143.1};
DE EC=1.1.1.1 {ECO:0000313|EMBL:CAM68143.1};
GN ORFNames=LINJ_23_0410 {ECO:0000313|EMBL:CAM68143.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM68143.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM68143.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM68143.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM68143.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM68143.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; FR796455; CAM68143.1; -; Genomic_DNA.
DR RefSeq; XP_001465717.1; XM_001465680.1.
DR AlphaFoldDB; A4I076; -.
DR SMR; A4I076; -.
DR STRING; 5671.A4I076; -.
DR GeneID; 5069140; -.
DR KEGG; lif:LINJ_23_0410; -.
DR VEuPathDB; TriTrypDB:LINF_230009000; -.
DR eggNOG; KOG0023; Eukaryota.
DR InParanoid; A4I076; -.
DR OMA; EAIFPMV; -.
DR OrthoDB; 1550at2759; -.
DR Proteomes; UP000008153; Chromosome 23.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF85; CINNAMYL ALCOHOL DEHYDROGENASE 6-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CAM68143.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 10..344
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 352 AA; 38458 MW; 49AB9BB36192AF73 CRC64;
MPTEAHGWAA LSAKSKLEPF TFQRRDVGPD DVVINIAYCG VCHSDVHQAR DEWDGSTFPM
VPGHEIVGHV TKVGSEVTKY KAGDRVGVGC MVDSCMKCRQ CERGLEQYCV NGASFTYNST
QQDKKTPTFG GYSDHVVVRE HFVVSIPDNL DLCAAAPLLC AGVTTFSPLR YWGVKKGTRV
GVVGLGGLGH MAVKLANAMG AEVTVFTRSS NKVEEAKNLG AHHVVNTNNE QEMNSIQGTL
DVIVDTVGMS HDLRPYMMTL DIDGKLALVG MPEHAHPPLD PRRIIASRQC VGGSNIAGMP
ETQELLNFCG EHNITATVEK ISIECINEAY ERMLASDVRY RFVIDMASLK RE
//
