ID A4I5N8_LEIIN Unreviewed; 399 AA.
AC A4I5N8; A0A2K4Z0Q7; A0A381MNX3;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Putative alcohol dehydrogenase {ECO:0000313|EMBL:CAM70108.1};
DE EC=1.1.1.1 {ECO:0000313|EMBL:CAM70108.1};
GN ORFNames=LINJ_30_2100 {ECO:0000313|EMBL:CAM70108.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM70108.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM70108.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM70108.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM70108.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
RN [3] {ECO:0000313|EMBL:CAM70108.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM70108.1};
RA Aslett M.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AKK31259.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MHOM/00/97/3277 {ECO:0000313|EMBL:AKK31259.1};
RX PubMed=26730948;
RA Vikeved E., Backlund A., Alsmark C.;
RT "The Dynamics of Lateral Gene Transfer in Genus Leishmania - A Route for
RT Adaptation and Species Diversification.";
RL PLoS Negl. Trop. Dis. 10:E0004326-E0004326(2016).
CC -!- SIMILARITY: Belongs to the iron-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00007358}.
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DR EMBL; KM411814; AKK31259.1; -; Genomic_DNA.
DR EMBL; FR796462; CAM70108.1; -; Genomic_DNA.
DR RefSeq; XP_001467057.1; XM_001467020.1.
DR AlphaFoldDB; A4I5N8; -.
DR SMR; A4I5N8; -.
DR STRING; 5671.A4I5N8; -.
DR GeneID; 5071101; -.
DR KEGG; lif:LINJ_30_2100; -.
DR VEuPathDB; TriTrypDB:LINF_300026200; -.
DR eggNOG; KOG3857; Eukaryota.
DR InParanoid; A4I5N8; -.
DR OMA; HAMSHQV; -.
DR OrthoDB; 5473018at2759; -.
DR Proteomes; UP000008153; Chromosome 30.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd08189; Fe-ADH-like; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR018211; ADH_Fe_CS.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF102; ALCOHOL DEHYDROGENASE 4; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR PROSITE; PS00060; ADH_IRON_2; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CAM70108.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
FT DOMAIN 23..390
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 399 AA; 43420 MW; F730AF4CB2F3F71F CRC64;
MACRSYQFTI CATSYLLRWR APAVTQGSGA LATLPHLVRG ARLKRGLLVT DAMIMKLGLV
DDFIDEMKRQ GAELAIYKDV LPNPTIDTVE EASALYKKNK CDYLVAVGGG SVMDCAKLIG
VRQARPRTPL PYMRGLLRVL WPLPPLIAVP TTAGTGSECT IAAVVSDPAK KDKLVVMDPF
LTPSHCVLDP ALTMTLPKFV TATTGMDALT HVVEAYTNVF HYRTVDKAAL RAMELLAKYL
PCAYKDGSNL EAREKMLQAS YLAGLSFTRA GVGNVHAAAH AVGGLYNVPH GYANAVILPH
VLDMYGSAAH KSLARLAEAA NIVGGNDAEK AANFISWVRE MNAQMQIPTT LGASDSRWVP
QEEDIPFLVK HAVIEANPFY AVPVIFGEEE MTELFRRIM
//
