ID A4IC65_LEIIN Unreviewed; 6624 AA.
AC A4IC65; A0A2K4Z787; A0A381MVL8;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 100.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAM72440.1};
GN ORFNames=LINJ_35_5080 {ECO:0000313|EMBL:CAM72440.1};
OS Leishmania infantum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5671 {ECO:0000313|EMBL:CAM72440.1, ECO:0000313|Proteomes:UP000008153};
RN [1] {ECO:0000313|EMBL:CAM72440.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM72440.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM72440.1, ECO:0000313|Proteomes:UP000008153}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JPCM5 {ECO:0000313|EMBL:CAM72440.1,
RC ECO:0000313|Proteomes:UP000008153};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796467; CAM72440.1; -; Genomic_DNA.
DR RefSeq; XP_001469334.1; XM_001469297.1.
DR STRING; 5671.A4IC65; -.
DR GeneID; 5073432; -.
DR KEGG; lif:LINJ_35_5080; -.
DR VEuPathDB; TriTrypDB:LINF_350059500; -.
DR eggNOG; KOG1426; Eukaryota.
DR InParanoid; A4IC65; -.
DR OMA; FSARTHW; -.
DR OrthoDB; 166249at2759; -.
DR Proteomes; UP000008153; Chromosome 35.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd12885; SPRY_RanBP_like; 1.
DR Gene3D; 2.60.120.920; -; 2.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR042469; HECTD3.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR044736; Vid30/RanBPM/SPLA_SPRY.
DR PANTHER; PTHR46654; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR PANTHER; PTHR46654:SF1; E3 UBIQUITIN-PROTEIN LIGASE HECTD3; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008153}.
SQ SEQUENCE 6624 AA; 733166 MW; 1622EA4D4DD909E6 CRC64;
MESQSSDFSE LDVDEAFSDD HQDSQTRVLS DDEDYSSDNS EHSTAARAAP AEGSAQRSAG
QRSGRARGIG SESLRPLRES SYPVEYLFAQ TTLKEKYSTE VSTVNEEKRV GLKSLGGLVK
YSSADLLTRA WCLCPSELKN REHPLYSKLP KCPEVLETRF GDTDEISQFM CSIALQLGER
YHRVTPVYLR SLLVQAVVRD EIAGANQSVA NSTPYADALL DPAWEGESAC ADETDDVSGN
EGSDEVQDEN IEVESAVSAF DFSVALILPV VSQGITYESL HLLHTLVDRC LSSSTEVAVL
RSWGVRRIMR LLLRHMNVHA GQSVNKRWLA TTISLLSKIV LSSGDTKVFF SLLRWSLHHP
DTIAMLHMRG VRGIVERVEQ KSAVRVRLSI PTVTPKEQTI SFIHSVGSTP ASVTGLCVFT
EEDAPRCIVF TENRSFKVAL TPPFEVLCCS STAPDSCRGV YVESDMSICV LGDHGKVFVI
NKDTLMLTRT MSPPSHLLGS TQFPLYIGDG EYVSSYFLAG ISTERQACFT GNEVSGALTP
STITLPRTCD SLSIQFYLCP VITGTVNEMT LLHLTTGSKN WLSVSVSLNP LTSTMVLMFR
HGQDAFAEIR EPLRAEWALW SASLTSTNDT AAWSVFKNGV MCDTRSQSGA LIQPSGAVTP
IFFKGRLNAH LSTLQLWSRA QSVDCMRNCA LEHTPESKSQ FLVFSFLMDE GLGRSFHSPQ
TGYVWQGTGV IWDTPPRPFP VNRHSPHKVH WRPSGNYYIV TNHFEYAIIE PQATTWIDRD
GRVVEQAEGL LSVSERPFYN ITDGYFFLST QDTVGIRSVK SNSPPAAYLQ HLPSMVVGKQ
FCAQVVESVM RRTPITAKQY LEYLVHRTNL HLLTYSDDQG SGPVHLSSSL RENLSVVGRL
LDLTEYLVSG IESSVKECLR PELLLCLVGR VLNIYVKLFE RQCPGQVVRS VVDAHKRLQS
LNTKVKQDEF LQEAASVFGD LNQVILARCV SHDFQLKLIT DSASLKDVRQ LLQLESLSQF
VASVIKRDMK KMFMTFLHRL KEECQEEATL IFDSKPRQIN ASEAMLSTLL GMLSQQGHSQ
WHLVAAALIS SLCKWIIRCF EERYPSDAER YANVDVLKET SIGIVLFPVV HYMCDMQLDS
SIAPDALKAL NDARKCLSRY SLAPGKRGKK FVSFSETHYV ASPPQLKAPF YASLSLQYAK
SIKVEFLDSP ELDRASSTVT VSLVTNNCLT SVDVLHPGQN AVFLEGAQVS IAYAAEATLD
SPAPGVALNV HTVVELATEK TDWVRDICLA LSYIIIRVTQ HNLHNTAPSG SAIRRDSFLR
GGLSASVQKC NKIPLSPGNK EECADLHAQL CAVAEETDPS LTVAWSALYE KSRIQYSKRL
EGIMRWASCA LAWQTLSLPA EDEKTVEQLL CSSVNAIKRK TFLLLEALQQ GREEAIVGRA
RFLLFNITPR LFGEWQLIEH QHTEEPLTAE ADRGSRQLSR LAYSVGNRSR ATVASFQMPT
AHALDLSSNY RGSLLSTRRT ASRTLDESPV NIFTKTLRSE EESLPNKIIY YLINGLDKPT
EDICKDMVLK TQQAVYQTEA YKLQEDLCKS FANDREMLSA ILMTHLKYRL EFSQSTIVAA
SEQGEAASEA NVGFDHHYTE QMIGCGMLRE LELQKAVCSF VQSSLRSLLH KLDDTQDFPY
VEAVYMCATL CHPWDGVDMS ILQPREIFAF LKKLLTTACE LRLESASSDT DKYYESRGLF
DLAHRCLVIP NAMLQTSVEG VHIVQSEVQG LHVENVNVVF SARTHWKAHG ANVRIPTKTC
EADYYANYGI PKVISEFPDV QYYEVALDFA LHPSNPELSM GLSLVPLSPL DPVRADYVLS
LASTGRVHRP EKQDRQLCNP WKVGDVVGCG LMAPSNSVFF TLNGEFLGVV AEVPTLSTVI
PFVSVRGDDT LMKVIVNFGE EQSFRFDLAS LHCSCRHRYL TPSVVCDTVI ITTDYLVTMC
YKGLSKGEDT SVTSDEAISG LLEKATAFLS SSTITLMVKL NACSPGQSSR IEQIVVLLSR
LLHCVSIVIE CFRYDAVTRR THATVLQLCA AILTRCRDKW VKVRASQCLA MLCKILRPQY
LVEASEALRG LVSFEDIVQQ LVDLARIKFI KEAEAPMQPP RWVGGTTVVK GKGTFFGSVP
LPKKGTHLVG FRIKRRQQQV QGPGAPLGGC YYLGLAHGQP SIPNMGNLIS RSDVYVLQDT
DDQDQVAHLL LRRHCIPRNN HRRVYGNDEV VWVEFNADYG EIAFYRENMV MIGLAFANIT
QVDDLYPIAF LFNDDASCEI IAPPSLTDES VEHWTESLRR SAAIDTLQEL HVVPGFSAII
SLMVQRSVSQ LDCSLDECLV ALGVLGGERS YLYCQHDTYG MVVVHAIAEV TGKVVVFLAS
DEDKRLFSVQ PQGLKPSFIQ TPLYQSNAPD AHSCATLLSS ELYRILYEAS AVAPLLQSEE
GARHKVERQY EESLSSAIAT NLIGILTEQQ MRSSPKLARA ASTSPETSGA EFPYRRFNSS
VIFSGQSVSV DLHCSTKTLY VPNPSIAVTT AEGCSVVRGN VQLDQRFTLA VSVTQTSIND
LMYVGFTTTR MRWPESQDEV ASWEDAWVLC NRDSVATNSV NCCMEPGIIF GAANKVFQSG
DVLLMRVDRH ERTVAFTRIR NSEQTDLGVL FEGIPAACDL RPMVVCGEES VVVFSTLDSC
LFPSRLTYPV SNFNNPSCER VTCCSCSRRL MPPWYGSEDN VALCEWCFSL WKRPKDMFFV
VSTTSRTIPE YLVSDHCPET LVAGDYVEFE ENTGLQWSNI RSVNSEILGG TCIALNDESF
AFSEELPQFG QRRVDVRLSH IAGVPGHPFS GLHTFTPLWR DGQQIGPTCS LRGDCVAVSA
TMLPMRTKLF LCFHIESNSR NTLFSMAEVF VGVTNLADAP RPMSRADLEH LCAAKSVRGT
WCDTSEKVSS SGCVNMLVDC LNSSVFFSSS LSGLHGKPFV ISGSMSAEAE EDNLRLLVFS
HEPCVVRFSE GLVSYNECVE PSFAPLAIGL FPEMGDALSV DTFNEAIVLM DTVDRTQTYT
KAEWRYSPHV DKLDNGTLFY VGDTVTFFHD GTTIHVYIQG IELASLELSD AQRSERLRVV
AYLSTRGTTA TIVPPLYGTS HFGKIMRVCS PDVAVVESVS EHGKRSTFAV HKSAVRFCAL
VAAAGREKPG LCDGDPVAFK IGGLQISKRG TIASVQGAVV NVCESSDKRN LISVNMNQCF
LLRNEGKQQY NYELYPLISP PTSSITRVFE VGKKKFRLQS RGSYNGIMFD CKTSETIELI
GMSVLTRVTG CHQVQTYFRK GSSVNHERDG RSWTIIFDDM IDMTADHQFS IPFTPITVEG
GTTFSFYINT SHNCGIGFYC EEDGCSGEIG QELDADGTLS VYLGRKSGSS DPFTEFSMSP
RGFCGTIQYK QNHGSTLPSI EGKLFPRPSM EANLCHCSES LRLICRPLTT SKDIVVTFRV
RVFSLAVRII SFTMPVLLLN PSARVPQGIS HCSISMFYTP EDRLERQWIW NSRFLVQGNA
SEAVLSPASL SLEQGTYMFQ VLLKNIESEG VGAPPHLCLL SSSDPLYERK NDLIAVSGFF
GDVTCEANRP VLEGELHTMI PGAHLNQNNS ASYNGIMFDL RSKKEITLEQ VFCISQTTSD
CVTVRIFWRE GSMEGAERAP HQWREVITKE VAVVDKHPFS VGPLMLRMRA NQVYSIFINT
SSSCGVRFYN SSDGHVGDIR DEFDSDGILS VYVGRKSESS SPFVELPLEP RAFRGRITYR
TYALQNTDAM EHATFPYVRG FLVTRMLVAL MSYVELSSVG HSGNFSYEQL LKTTSLLATS
PMDSLADLMG AENVLASLIR DSGEVRNINV TIPIAGGHCS LLVPLAKGDI ALLTDLQSAE
SNALVQLQSG VRPDGMALVR HRDASVPFSV PAKRLLPITK CVMCGWMYTQ EVCAACNAEH
MPILSEEARA VEIVANGLQQ TRSGLSIQET IEAAVAAVGS AWGKDGMLMP VDAASKDRPE
VQASVAPRGV VFSIPVALLL SEEEYSEGGG LLCPFVFHPA AGAAVALRLS TTNEVFSVQF
VTSGAASAIA EATEEAPAHF FLLQLWGGDG EARHGLTEDP VPFVICRGGE SSVPLVENVH
AGYAASLQRD GFVTLFLEIQ ACSPLPLTAP VLAKPDCWMW EHNSVEAQLC STSTTYLARL
FSSVQGVSDW PHYSAFMVTA KGKETMIFLE LHVSEVQRRT VSSSGMMVYS APSPLPVRIR
KPFNMQSDEV LTLRVTTEGD FFIYDTNDIV RCSISKEELY GGKHQRQLHR IGFVSVDPEK
VTALLYVPEK TRRNPRANIA SDAKTTLSSS SLLPKTYSPA WVRLDASRIT VSRNGLTASS
VNELGGGDAV MGSPLPATGV WSFVVHIHRK DSQPGTPLGS GFFAGVALSD FAQFAPEYSA
IKTYVGSLWV VQDVQDEDSM PNQEPLPPLM RGSYGQGVLF FDSTKLLFIV DRSNGTLSIS
RDNESPHVVF QGIPHGASVS PFVRLDHPNS SATLARFSSA VEYTRLHQPS LEKVLWLQPI
TPSLLRRYPL FMATQTFPFI SELVRKLPTR LAGLLERCWG EQIARSRFEY RVAQALEELA
GLGAFARSLP EANDAKVDEI ADYLSKSARR EVVVFPARTS ETAVQTSPLD DSTGVHVRLP
PTYELVGRVE ATNMVRVLHF DREFGAVERT LHLFFLDDAT LNLHSTNNVL PHLSVMRQHE
ILPALNRAEA VAVMADGWFD CSLADYDAVL NVKEEEEIAS SLVYALEHWH LHQLPHGHVH
PRNVYLRVEH GEVVQCCLWN VHQLSPKSKY ASHELRDSGV RSLFGDRWAC WQILHSFQHL
LAHDPRVAEC VELMVDEATS ISRALQLSVA FQGSFSDSGE GLTFTLRTGS RLRGGSGSYN
GIMFDVVAKN NTICITKLSF IPDANTVATV RLYARSGSFM GFERDPEAWT KLFEEEMALK
DTWEVTLENF EPITVPGGAR VGIFLHTTSG SGVLFSENEG LQGKTGDVEE ENDDIGITIG
KKSESANPFV AVQSQKRLLK GSITYTVLMR SNGPRSCLIS CCEPVLSDGK GEEQVELRLV
QVSSAGRKGE SDLQVPGGVR APGGARTQLP ATQLPTSSGY CLQVLSAPNT RRSGSDRNNV
LTLVAPSQFV WCRAPDVVSV RPGLLREVAD PLVRFLAAEG LRRRRTLLRQ HNLSSRVFPC
RPLHFFLLPT HDTDTGAPSS MCSVTHPVLS GGSVFISEPI SSSCTLSLWQ KAAGAAVLLV
MDHIPTTDEV TRRTTASPSD SLVGARSCGG FVHVDDALRY VTSTRDRVHL RLKASLSCRP
LFVVARLRHA GHRDSQLFVY SSAMEHELFT PAAEGCFFMT NRKATPPDDN AAFATTWHAC
GGLIALEGRD KGCAGAESLV RLESLVSSRD EVRFVCPPRC PGESETVVRE KMKTGEAQPN
VAVQHAIPQA PLLIELREQA KWKSVRHLVE FTCLSSSLAL CGARGAWQVA GGINCSAVVS
SPRFTTAERH RVHLRLQFPR RMPMDLQLDC KSGSANPIRL LHGSYKSLRS RLFDPAVREV
FVWLDINLQT REVVVLSSDG TVYHPFIEES VLSSDVQLGF VSHAPGSELD VLEWRVCSSQ
IRGEMTASVF KRVLEETPLA QLSANTSLTV GTVCRHSARG AFPSKQEVNL STEKQMGVLM
VTYARMLLEK TLLSQEKART AAQPQFLRLL SLTALRKHPD IARILDGEIK QGSFRLVSQC
VAQLSAPFLM QVPAEVDAGI NVIASLMRND VFRRTILNAF GSSLVLILLR AATVHTRSTR
HTALHCVQEL LADGRVPLPS HHVLSAHLRP LTDMMASLCR RERMGSAVVQ TGVTLIADLI
ERFQRERPEH PYRDVPTEIP YKLVCCAREI VRAITHDPPL PFPSAMVAEV SSQHTMRCEV
IKRVIDAENR TCAIGVFKEE GRHPDSSMSF TVRMNGNRRG SVVVGWNSAT PRQQQDESLP
CFGYLVDGRT GAVFLCYNHT KSMKGLALRV NAGDDLITTA NYRDHKITFE LKRAGITVGE
TKFDTEREVI GLPFFSAEYS DDATVDLKSF HPGPQTLSVS RLYEQILRAP YEQDQMPAQS
FEFYAELNLF AQTVLNVHSS ADIVSRVVSE TTVASHELAS FTQVSSALNA GAFAERVSLA
PLTPYLVRLK KLDELTAEFA PLINLRRRTE LFDIFGVLKN LCSRETEEQI QTRIMAPFQN
MQGKKVSVTI HTMQAQPTTS TGPFQTLMRS VFGQLYLQLQ QATIDIFYVS PIFTVKLAGF
GSTDAGGPYR DVLSQLATEI MTTHPSKQCQ LNPLFVNCGR GDVTAIMPNV ALIKSAQIPL
MLEFFGKLLA SLFLTQDVLA VELPPLFWKL LLGEEATIKD LSAFDADIAR LLQPEELMMR
THEELEERFP GITAVWKAIV DDNQQFLLDE NLPPETLDGA RLLSRRIMVS EIHRFEEAIG
YIQQGFDQVL PLYTLHAYRW QKVELLICGT PKLTFADFYN KCDIQLSTAD ASMFLSVLEG
MTDEDRTLLL RFTTGQSRLP LKTKIKVTHN GSKDTLPTSS TCFFALRLPS YSSAEKMKER
LLYAVRQCKA IDADGQAREH LIID
//
