ID A4IGU5_XENTR Unreviewed; 288 AA.
AC A4IGU5;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=LOC100037908 protein {ECO:0000313|EMBL:AAI35252.1};
DE SubName: Full=Secreted frizzled-related protein isoform X1 {ECO:0000313|RefSeq:XP_031751429.1};
DE SubName: Full=Secreted frizzled-related protein precursor {ECO:0000313|RefSeq:NP_001090810.1};
GN Name=sfrpx {ECO:0000313|RefSeq:NP_001090810.1,
GN ECO:0000313|RefSeq:XP_031751429.1,
GN ECO:0000313|Xenbase:XB-GENE-495296};
GN Synonyms=LOC100037908 {ECO:0000313|EMBL:AAI35252.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI35252.1};
RN [1] {ECO:0000313|RefSeq:NP_001090810.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI35252.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole embryo {ECO:0000313|EMBL:AAI35252.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001090810.1, ECO:0000313|RefSeq:XP_031751429.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031751429.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031751429.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000256|ARBA:ARBA00010054}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; BC135251; AAI35252.1; -; mRNA.
DR RefSeq; NP_001090810.1; NM_001097341.1.
DR RefSeq; XP_031751429.1; XM_031895569.1.
DR STRING; 8364.ENSXETP00000010451; -.
DR MEROPS; I93.002; -.
DR PaxDb; 8364-ENSXETP00000051708; -.
DR GeneID; 100037908; -.
DR KEGG; xtr:100037908; -.
DR AGR; Xenbase:XB-GENE-495296; -.
DR CTD; 100037908; -.
DR Xenbase; XB-GENE-495296; sfrpx.
DR HOGENOM; CLU_054647_0_0_1; -.
DR OMA; VSKLCHR; -.
DR OrthoDB; 4814466at2759; -.
DR Proteomes; UP000008143; Chromosome 2.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd03580; NTR_Sfrp1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF128; SECRETED FRIZZLED-RELATED PROTEIN 2-LIKE; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001090810.1};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..288
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001090810.1"
FT /id="PRO_5033207136"
FT DOMAIN 29..149
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 165..288
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 44..90
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 81..119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 112..136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 288 AA; 32221 MW; B103DDD90D2949CE CRC64;
MRFLLLFLGI VGNLCPSAAL PFILTQLSTR KSSCKAIPSS MTLCHGVGYS EMRLPNLLGH
DTMKEVLQQA GSWVPLLTKQ CHADTKKFLC SLFAPVCLSE LEEAVYPCRS LCEAVRDGCT
PVMAAFGFPW PDMFNCTQFP LGNELCVPPA GSEDKQQEVK EEAPCSACRN RGDADKDFLQ
NYCSSDFALK INIRSVSTLE GDVMVVPEAR SRTVYKSKGW SDEELRKTVL WLSDGDNCLC
QDIHEPGATV LVLGHRADDR LVISWVRKWQ KSEKETKRFS RTVRKLQC
//
