ID A4IRX6_GEOTN Unreviewed; 470 AA.
AC A4IRX6;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Xaa-His dipeptidase {ECO:0000313|EMBL:ABO68080.1};
GN OrderedLocusNames=GTNG_2735 {ECO:0000313|EMBL:ABO68080.1};
OS Geobacillus thermodenitrificans (strain NG80-2).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX NCBI_TaxID=420246 {ECO:0000313|EMBL:ABO68080.1, ECO:0000313|Proteomes:UP000001578};
RN [1] {ECO:0000313|EMBL:ABO68080.1, ECO:0000313|Proteomes:UP000001578}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NG80-2 {ECO:0000313|EMBL:ABO68080.1,
RC ECO:0000313|Proteomes:UP000001578};
RX PubMed=17372208; DOI=10.1073/pnas.0609650104;
RA Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X.,
RA Han W., Peng X., Liu R., Wang L.;
RT "Genome and proteome of long-chain alkane degrading Geobacillus
RT thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; CP000557; ABO68080.1; -; Genomic_DNA.
DR AlphaFoldDB; A4IRX6; -.
DR KEGG; gtn:GTNG_2735; -.
DR eggNOG; COG0624; Bacteria.
DR HOGENOM; CLU_031786_2_0_9; -.
DR Proteomes; UP000001578; Chromosome.
DR GO; GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd03888; M20_PepV; 1.
DR Gene3D; 3.30.70.360; -; 2.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR001261; ArgE/DapE_CS.
DR InterPro; IPR036264; Bact_exopeptidase_dim_dom.
DR InterPro; IPR010964; M20A_pepV-rel.
DR InterPro; IPR002933; Peptidase_M20.
DR InterPro; IPR011650; Peptidase_M20_dimer.
DR NCBIfam; TIGR01887; dipeptidaselike; 1.
DR PANTHER; PTHR43808; ACETYLORNITHINE DEACETYLASE; 1.
DR PANTHER; PTHR43808:SF33; DIPEPTIDASE SAOUHSC_01868-RELATED; 1.
DR Pfam; PF07687; M20_dimer; 1.
DR Pfam; PF01546; Peptidase_M20; 1.
DR SUPFAM; SSF55031; Bacterial exopeptidase dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00758; ARGE_DAPE_CPG2_1; 1.
DR PROSITE; PS00759; ARGE_DAPE_CPG2_2; 1.
PE 4: Predicted;
KW Dipeptidase {ECO:0000256|ARBA:ARBA00022997};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000256|ARBA:ARBA00022997};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 263..337
FT /note="Peptidase M20 dimerisation"
FT /evidence="ECO:0000259|Pfam:PF07687"
SQ SEQUENCE 470 AA; 51676 MW; A35593F074DA5641 CRC64;
MTLNINWIEE ARKRKDDLVR DVQALVRIPS VRDDSEAQPG APFGLKVAEA LDYMLTRGQA
EGFRVKNVDG FAGHVEMGQG EKLIGVLGHI DVVPPGDGWT VDPFSAHVRD GRIYGRGAID
DKGPTIAAFY AMKIVKELGL PLSKRVRLII GGDEESDWRC VDHYFKHEEM PDIGFVPDAD
FPIIYAEKGI IDADLQYRLT GSEETGEMTL RSFQAGRRYN MVPDAAEAVV EGAGLEEWSS
RYERFCRDHG LNGNIHHSGE AAVLTLEGVA AHGAEPERGK NAGVYLAQFL ASLPLDGGSR
PFVQFVASSF FGDTRGRKLG LAYRDERSGE LTVNVGVLSY DRAQGGTIGL NIRYPVTADG
ETIRQTLSNV AVERGLTLGR FHDTKPHYVD PDHEWIRTLQ RIYEEQTGEP GRLLAIGGGT
YARSLTAGVA FGALFPGRPD VAHQKDEYVE IDDLVKATAI YAQAIYELAK
//
