ID A4J552_DESRM Unreviewed; 474 AA.
AC A4J552;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Major facilitator superfamily MFS_1 {ECO:0000313|EMBL:ABO50205.1};
GN OrderedLocusNames=Dred_1678 {ECO:0000313|EMBL:ABO50205.1};
OS Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1)
OS (Desulfotomaculum reducens).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptococcaceae;
OC Desulforamulus.
OX NCBI_TaxID=349161 {ECO:0000313|EMBL:ABO50205.1, ECO:0000313|Proteomes:UP000001556};
RN [1] {ECO:0000313|EMBL:ABO50205.1, ECO:0000313|Proteomes:UP000001556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MI-1 {ECO:0000313|EMBL:ABO50205.1,
RC ECO:0000313|Proteomes:UP000001556};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Sims D., Brettin T., Bruce D., Han C., Tapia R., Schmutz J., Larimer F.,
RA Land M., Hauser L., Kyrpides N., Kim E., Tebo B.M., Richardson P.;
RT "Complete sequence of Desulfotomaculum reducens MI-1.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000256|ARBA:ARBA00007520}.
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DR EMBL; CP000612; ABO50205.1; -; Genomic_DNA.
DR RefSeq; WP_011878020.1; NC_009253.1.
DR AlphaFoldDB; A4J552; -.
DR STRING; 349161.Dred_1678; -.
DR KEGG; drm:Dred_1678; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_001265_10_6_9; -.
DR OrthoDB; 9803985at2; -.
DR Proteomes; UP000001556; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17474; MFS_YfmO_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG-like.
DR PANTHER; PTHR43124:SF3; INNER MEMBRANE TRANSPORT PROTEIN YDHP; 1.
DR PANTHER; PTHR43124; PURINE EFFLUX PUMP PBUE; 1.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001556};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..406
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 474 AA; 51065 MW; 176E0A5D0F074C9E CRC64;
MSQAASTDIQ ENKVNKYTLA ALAGVPLIMV LGNSMLIPVL PQMAKSLNVS QMQISLIITL
FSVPAGLVIP FAGFLSDRFG RKKIIIPGLF LYGLGGLLAG AAALIFKENA FPWILGGRIL
QGIGAAGTAP IAMAFCGDLW KGKERAKSLG VIEASNGLGK VASPILGALI GLIAWWYIFF
FFPVVIAVVI LGVWFICKEP ETNKQPKKVN EYVGSIKNIF KKKSPLLLTS FFAGSAALLI
LFGVLFFLSD YLEKKFGLDG VIKGAALAIP VLFMSTTSYV TGALIKKKIK LMKWLVVIGH
GLIGASLVTL PLFNNVYIFF AGISVAGIGT GLVLPCLNTL ITSSTNKDER GLVTSLYGSV
RFLGVAAGPP LFGWLVEKGS DMMFWASASL AVISAVLAFF FIKVKAIQTS QGNNYDSSKQ
KQSKQTLIMP VKQPFIAYKS LAWHPESNLI VRKPMPQMKK ERINEVGQVN TGES
//
