ID A4KTS1_9NEOB Unreviewed; 234 AA.
AC A4KTS1;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Chemokine receptor 4 {ECO:0000313|EMBL:ABM74079.1};
DE Flags: Fragment;
GN Name=CXCR4 {ECO:0000313|EMBL:ABM74079.1};
OS Elachistocleis ovalis (common oval frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Microhyloidea; Microhylidae;
OC Gastrophryninae; Elachistocleis.
OX NCBI_TaxID=367647 {ECO:0000313|EMBL:ABM74079.1};
RN [1] {ECO:0000313|EMBL:ABM74079.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1055ElaOva {ECO:0000313|EMBL:ABM74079.1};
RX PubMed=17183706; DOI=10.1371/journal.pone.0000074;
RA Bocxlaer I.V., Roelants K., Biju S.D., Nagaraju J., Bossuyt F.;
RT "Late cretaceous vicariance in gondwanan amphibians.";
RL PLoS ONE 1:E74-E74(2006).
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; EF017969; ABM74079.1; -; Genomic_DNA.
DR AlphaFoldDB; A4KTS1; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001277; CXCR4/ACKR2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF594; C-X-C CHEMOKINE RECEPTOR TYPE 4; 1.
DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00645; CXCCHMKINER4.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:ABM74079.1};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..234
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABM74079.1"
FT NON_TER 234
FT /evidence="ECO:0000313|EMBL:ABM74079.1"
SQ SEQUENCE 234 AA; 26771 MW; C36DF2BA329300BD CRC64;
VLVMGYQKKS RTMTDKYRLH LSVADLLFVF TLPFWSVDAA IGWYFKDFLC KAVHVIYTVN
LYSSVLILAF ISLDRYLAIV HATNSQGSRK LLAEKIVYAG VWLPAILLTV PDLVFARVTE
PNGFFICDRI YPLENQVQWT IGFRILHIMV GLLLPGFIIL ICYCVIISKL SHSKGHQKRK
ALKTTVILIV AFFACWLPYY ICLTIDTLAK FGIIKLDCEM DNTIHKWISI TEAL
//
