ID A4KUB0_STRHI Unreviewed; 1533 AA.
AC A4KUB0;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=TlmVIII {ECO:0000313|EMBL:ABL74938.1};
GN Name=tlmVIII {ECO:0000313|EMBL:ABL74938.1};
OS Streptoalloteichus hindustanus.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Streptoalloteichus.
OX NCBI_TaxID=2017 {ECO:0000313|EMBL:ABL74938.1};
RN [1] {ECO:0000313|EMBL:ABL74938.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 31158 {ECO:0000313|EMBL:ABL74938.1};
RX PubMed=17216057; DOI=10.1039/b615284h;
RA Tao M., Wang L., Wendt-Pienkowski E., George N.P., Galm U., Zhang G.,
RA Coughlin J.M., Shen B.;
RT "The tallysomycin biosynthetic gene cluster from Streptoalloteichus
RT hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis
RT of the bleomycin family of antitumor antibiotics.";
RL Mol. Biosyst. 3:60-74(2007).
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
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DR EMBL; EF032505; ABL74938.1; -; Genomic_DNA.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..433
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1447..1522
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 876..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1533 AA; 161700 MW; B208419FC3C0DE8A CRC64;
MSDDAPEPIA IVSLAGRFPG ADDVPTFWEN LRAGEESIRR YTREELLALG RDPALVDHPR
FVGAEGVLGD IAGFDADFFG YSPREAEIMD PQHRLCLETA WAAFDSAGYD PAALTEPVGV
FLATSLSSYL VRNLLSDPGL ARGIGGFPLL IHNDKDFAAT TVSHKLGLTG PSYAVGSACS
SSLVAVHLAC QSLQSHECDM ALAGGVSLQV PQGQGYVYAE DGIYSPDGRC AAFDASAGGT
VGGSGVGLVL LKRLSDAVRD RDQVHALVLG TAVNNDGANK VGYTAPSVDG QSAVIVEAHA
VAGISADTVG YVEAHGTGTS LGDPIEVTAL TQAFRASTDR TGFCALGSVK TNIGHLDAAA
GIAGLVKAAL AVRDGIIPAS LNFREPNPRI NFAATPFHVA DTTRPWRAEG APRRAGVSSF
GIGGTNVHVV LEQPPAPPLR AKRRRAAQPL VLSARTGEAL AEAARDLAER LRRDPGVDLA
DVAATLASRR AFPHRKTVVC RDVSSAISAL DLPNAPARVA DAERPVVFLF PGQGAAYPGM
ARELAREDVT FRAHLDECAD LLAGLGVELD AALDCPPGTV EATRLGQPAL FAVEYALARA
LQDWGLTPTA MLGHSLGEYV AATLAGVLSL PDALRLVSAR GRVQAAMAPG RMLAVSLPED
RLRPLLASGL SVSAVNASDR CVVGGEPSAV ADLAKALGGQ GIPTQMLPTA HAFHSTAVEP
VLDRFREVLA EVEFRAPSAR YASNLTGNWV RPEEACDPDY WLAHMRQPVR FGDGLARCLE
LGPVSLVEVG PSAGLTGLVR RHPLASGDHR AVRTIPGARD SGEKSEVDSV VTAVAELWAE
GCAVRWDAFH RQQEPRRVAV PAYPFQRERY WVEPAATTSG GSDLAAPVAS RPEGTGDRDW
PEKRPDIGSW GYRPGWRHAP TPVPDREAVA GRCLLFSSGP LGHAVERRLV AAGVDVERVP
ADPAICFDPD RPEHYRELVA GRGGAPRLVV HLWALEDALA RGGAAPSGLM PEVQRRGLHS
LLHLARALGA AENGGPTRLV AVTGGAQEVL GDDLRHPEHA TALAAVKIIP REYPGMACTA
VDLDLTRLDR DLDWLAERVV DELLAAREST VVAYRGRRRF RLDHAPCPLE PGDPAVGPRP
GGVYLVCGGL GGIGLNLAED LGRLPAKVVL THRRPFPAAE DWADHLATHP ADDPTSVAIN
RLRGIIEAGG EVLVAPADLT DSDAVRAVVA EAERRFGPLT GAVHAAGVPD TAGVIHRRTT
ADTEAAIAAK VHGTAVLDEV LGDRPLDFFV LCSSIGSVLH KLKFGEVGYV AGNDYLNAYA
AYRAARRPGI TTAIAWTDWL ESGMSAVAQE RLVDRYDTGG TQSTVDSASV GPAGDLLGAL
TRDEGVEVFR RVLRAGLGPQ VLVSTQDLDA LLARHDAYTT GDHLAVVSGL SAHGGRSRAR
LSTAYAAPRS DLERTLAGWY AELLGYDQIG RDDDFFELGG DSLLALRLRS MVRSGYGVEV
SVAQLFDAPT VTGLATLVGH AVGGDPDRQE VVL
//
