ID A4N601_HAEIF Unreviewed; 619 AA.
AC A4N601;
DT 15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 15-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=CGSHi22421_09945 {ECO:0000313|EMBL:EDJ90361.1};
OS Haemophilus influenzae R3021.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=375432 {ECO:0000313|EMBL:EDJ90361.1, ECO:0000313|Proteomes:UP000003798};
RN [1] {ECO:0000313|EMBL:EDJ90361.1, ECO:0000313|Proteomes:UP000003798}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R3021 {ECO:0000313|EMBL:EDJ90361.1,
RC ECO:0000313|Proteomes:UP000003798};
RX PubMed=17550610; DOI=10.1186/gb-2007-8-6-r103;
RA Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C.,
RA Ehrlich G.D.;
RT "Characterization and modeling of the Haemophilus influenzae core and
RT supragenomes based on the complete genomic sequences of Rd and 12 clinical
RT nontypeable strains.";
RL Genome Biol. 8:R103.1-R103.18(2007).
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AAZE01000016; EDJ90361.1; -; Genomic_DNA.
DR AlphaFoldDB; A4N601; -.
DR Proteomes; UP000003798; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048931; SelB_WH_3rd.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF21214; bact_SelB_WH_2nd; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; SelB-wing_2; 1.
DR Pfam; PF09107; SelB-wing_3; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:EDJ90361.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:EDJ90361.1}.
FT DOMAIN 1..167
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 619 AA; 69946 MW; 766B3D5F38D063C0 CRC64;
MIIVTSGHVD HGKTALLKAL TGTSTAHLPE EKKRGMTIDL GYAYLPLENK VLGFIDVPGH
EKFLSNMLAG LGGVHYAMLI VAADGGVAVQ TKEHLAILRQ LQFHEIIVVI TKADRTNPEQ
IESLIQEIKQ NYSFLRGANY FVTSAETGQG INELRHYLAN LPELSDTQKP FRYAIDRVFN
VKGAGTVVTG TAFSGTVKVN DEIYLSTGQK VRIKAIHAQN TSSEQGIAGQ RLALNLNADL
DRTPMKRGDW LLQNEPLPPT DRISVQILAE VPLNESQPVH IYHGASRTTG KLTLLQGKNT
AKNDRTLAEI ILDSPLFLAF GDKLILRSGD TKTLIAGAQV LEINSPKRHK RTEVRLNFLA
NLALAENASQ RIALTLLHNA TTVRQLMWTE QLTSSQLDKA LAERGAVRYQ DWCFNTNYVQ
EKTQQILTAL NTYHEQHNDQ LGVSKARLYR MATLNQPENL IHHFIDEMLD DGRLQQTRGW
IHLPEHKIQF NTEEKSRWTD VLNEFEKANG QAIWVRDMAN ALAIDESIMR NFMYKAGKLG
YLTPIVKDRF FLTETLYAYA RLIKQIAEEK GKVSVNEVRD KLNFGRKLTV QLMEYFDRMG
FLRRKGNDHI LRDKNVFDL
//
