ID A4PDX4_SAUUN Unreviewed; 1936 AA.
AC A4PDX4;
DT 15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 15-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Myosin heavy chain {ECO:0000313|EMBL:BAF49657.1, ECO:0000313|EMBL:BAF75971.1};
GN Name=bMYH3 {ECO:0000313|EMBL:BAF49657.1};
OS Saurida undosquamis (Brushtooth lizardfish) (Saurus undosquamis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Aulopa; Aulopiformes;
OC Aulopoidei; Synodontidae; Harpadontinae; Saurida.
OX NCBI_TaxID=143315 {ECO:0000313|EMBL:BAF49657.1};
RN [1] {ECO:0000313|EMBL:BAF49657.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Fast skeletal muscle {ECO:0000313|EMBL:BAF49657.1};
RA Hossain M.A., Ikeda D., Nomura A., Fukushima H., Watabe S.;
RT "cDNA cloning and complete primary structure of myosin heavy chain from
RT brushtooth lizardfish (Saurida undosquamis) and wanieso lizardfish (Saurida
RT wanieso) fast skeletal muscle.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BAF75971.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Fast skeletal muscle {ECO:0000313|EMBL:BAF75971.1};
RA Hossain M.A., Ikeda D., Nomura A., Fukushima H., Watabe S.;
RT "cDNA cloning and complete primary structures of myosin heavy chains from
RT brushtooth lizardfish Saurida undosquamis and wanieso lizardfish S. wanieso
RT fast skeletal muscles.";
RL Fish. Sci. 74:921-934(2008).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AB275401; BAF49657.1; -; mRNA.
DR EMBL; AB297982; BAF75971.1; -; mRNA.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 5.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF44; MYOSIN-13; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 2.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 2: Evidence at transcript level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}.
FT DOMAIN 33..83
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 87..780
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 657..679
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1909..1936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 844..1573
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 180..187
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1936 AA; 221561 MW; 7FC0E26C49D7CB23 CRC64;
MSTDAEMAVY GKAAIYLRKP EKERIEAQSK PFDAKAAGYV ADVKELYLKC TILKRDGGKV
TVKVLDTQEE KTVKEDDVTP MNPPKYDKIE DMAMMTHLNE ASVLYSLKER YAAWMIYTYS
GLFCATVNPY KWLPVYDQEV VNAYRGKKRM EAPPHIFSVS DNAFQNMATD RENQSVLITG
ESGAGKTVNT KRVIQYFATI SVGGGEKKKD AAPGKMQGSL EDQIIAANPL LEAYGNAKTV
RNDNSSRFGK FIRIHFGATG KLSSTDIETY LLEKSRVTFQ LPDERGYHIF YQMMTNHKPE
LIEMTLITTN PYDFPMCSQG QITVASIDDK EELVATDTAI DILGFTGEEK NYIYKLTGAV
LHHGNMKFKQ KQREEQAEPD GTEDADKVSY LLGLNSADML KALCYPRVKV GNEYVTKGQT
VPQVNNSVAA LAKSIYERMF LWMVIRINQM LDTKQARQFF IGVLDIAGFE IFDFNSMEQL
CINFTNEKLQ QFFNHHMFVL EQEEYKKEGI IWEFIDFGMD LAACIELIEK PMGIFSILEE
ECMFPKASDT TFKNKLYDQH LGKTKAFEKP KPAKGKAEAH FSLVHYAGTV DYNICGWPDK
NKDPLNDSVV QLYQKSSVKP LPVLYPPVVE ETGGGKKGGK KKGGSMQTVS SQFRENLGKL
MTNLRSTHPH FVRCLIPNES KTPGLMENFL VIPQLRCNGV LEGIRICRKG FPSRILYGDF
KQRYKVLNAS VIPEGQFIDN KKASEKLLGS IDVDHEQYKF GHTKVFFKAG LLGTLEEMRD
EKLAILVTMT QALCRGYVMR KEFVKMMERR ESIYTIQYNI RSFMNVKHWP WMKVYYKIKP
LLKSAETEKE LAQMKDNYDK MKTDLATALA KKKELEEKMV SLLQEKNDLQ LQVASESENL
SDAEERCEGL IKSKIQLEAK LKETHERLED EEEMNAELTA KKRKLEDECS ELKKDIDDPE
LTLAKVEKEK HATENKVKSL TEEMASQDES IAKLTKEKKA LQEAHQQTLD DLQAEEDKVN
TLTKAKTKLE QQVDDLEGSL EQEKKLRMDL ERAKRKLEGD LKLAQESIMD LENEKQQSDE
KIKKKDFETA QLLSKIEDEQ SMGAQLQKKI KELQARIEEL EEEIEAERAA RVKVEKQRAD
LSRELEEISE RLEEAGGATA AQIEMNKKRE AEFQKLRRDL EESTLQHEAT AAALRKKQAD
SVAELGEQID NLQRVKQKLE KEKSEYKMEI DDLSSNMEAV AKSKGNLEKM CRTLEDQLSE
LKTKSDENVR QINDMSAQRA RLQTENGEFT RQLEEKEALV SQLTRGKQAF TQQIEELKRH
VEEEVKAKNA LAHGVQSARH DCDLLREQFE EEQEAKAELQ RGMSKANSEV SQWRAKYETD
AIQRTEELEE AKKKLAQRLQ EAEEQIEAVN SKCASLEKTK QRLQGEVEDL MIDVERANAL
AANLDKKQRN FDKVLAEWKQ KYEEGQAELE GAQKEARSLS TELFKMKNSY EEALDQLETL
KRENKNLQQE ISDLTEQIGE TGKSIHELEK AKKTVETEKA EIQTALEEAE GTLEHEESKI
LRVQLELNQI KGEVDRKLSE KDEGMEQIKR NSQRVIDSMQ STLDSEVRSR NDALRIKKKM
EGDLNEMEIQ LSHANRQAGE AQKQLRNVQG QLKDAQLHLD DALRSQEDLK EQAAMVDRRN
GLMVAEIEEL RSALEQTERG RKVAEQELVD ASERVGLLHS QNTSLMNTKK KLESDLVQVQ
GEVDDTVQEA RNAEEKAKKA ITDAAMMAEE LKKEQDTSAH LERMKKNLEV TVKDLQHRLD
EAENLAMKGG KKQLQKLESR VRELEGEVEG EQRRGADAVK GVRKYERRVK ELTYQTEEDK
KNVARLQDLV DKLQLKVKAY KRQAEEAEEQ ANGYLSKCRK VQHELEEAEE RADIAESQVN
KLRAKSRDAG KGKEAE
//
