ID A4VDY4_TETTS Unreviewed; 365 AA.
AC A4VDY4;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE SubName: Full=Zinc-binding alcohol dehydrogenase family protein {ECO:0000313|EMBL:EDK31736.1};
GN ORFNames=TTHERM_00077599 {ECO:0000313|EMBL:EDK31736.1};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EDK31736.1, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
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DR EMBL; GG662704; EDK31736.1; -; Genomic_DNA.
DR RefSeq; XP_001471343.1; XM_001471293.2.
DR AlphaFoldDB; A4VDY4; -.
DR STRING; 312017.A4VDY4; -.
DR EnsemblProtists; EDK31736; EDK31736; TTHERM_00077599.
DR GeneID; 7837005; -.
DR KEGG; tet:TTHERM_00077599; -.
DR eggNOG; KOG1198; Eukaryota.
DR HOGENOM; CLU_026673_3_3_1; -.
DR InParanoid; A4VDY4; -.
DR OMA; FTRTISY; -.
DR OrthoDB; 2267374at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR CDD; cd08271; MDR5; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR047122; Trans-enoyl_RdTase-like.
DR PANTHER; PTHR45348; HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG); 1.
DR PANTHER; PTHR45348:SF2; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009168}.
FT DOMAIN 17..363
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 365 AA; 41182 MW; 24ACAC022BA26E84 CRC64;
MTDLPQVYRV WECPQKGVES IQLVEKPLPT ELEEYEVLVK VKSAALNPVD YKCCDNEGGP
FDFQFPRTVG IDHIGVVVKL GPKVDSNVYK VNETVLLAHG SLKSKYGAFG EYKVQDIRTA
AIVPQDLIQQ VGESIYTDLA TIPCAGYTAL QIVMIKLRLP IYKDPNSISN RYIRNIVVTA
GAGGVGYFTL QLLKLWKENN FDEEEQKNIR IISTCSKSNF DFVLSLGATH AIDYNTENVG
KRVKEILGDN QLDVWIDLVD SKTTEEGLQT LGFRGELVVA VENTDYTNRL FGLSKSVHNV
TLGLAYLYGS SAHKSDLKYY GDIFLDLYRN KKITIEKKVI KLEELKHYLL EMKNRHTRGK
IVFQA
//
