ID A4Y7W4_SHEPC Unreviewed; 490 AA.
AC A4Y7W4;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Nicotinamide phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00035036};
DE EC=2.4.2.12 {ECO:0000256|ARBA:ARBA00035024};
GN OrderedLocusNames=Sputcn32_2326 {ECO:0000313|EMBL:ABP76047.1};
OS Shewanella putrefaciens (strain CN-32 / ATCC BAA-453).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=319224 {ECO:0000313|EMBL:ABP76047.1};
RN [1] {ECO:0000313|EMBL:ABP76047.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CN-32 {ECO:0000313|EMBL:ABP76047.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Mikhailova N., Romine M.F., Fredrickson J.,
RA Tiedje J., Richardson P.;
RT "Complete sequence of Shewanella putrefaciens CN-32.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinamide D-
CC ribonucleotide from 5-phospho-alpha-D-ribose 1-diphosphate and
CC nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00035007}.
CC -!- SIMILARITY: Belongs to the NAPRTase family.
CC {ECO:0000256|ARBA:ARBA00010897}.
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DR EMBL; CP000681; ABP76047.1; -; Genomic_DNA.
DR AlphaFoldDB; A4Y7W4; -.
DR STRING; 319224.Sputcn32_2326; -.
DR KEGG; spc:Sputcn32_2326; -.
DR eggNOG; COG1488; Bacteria.
DR HOGENOM; CLU_012550_2_0_6; -.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
DR CDD; cd01569; PBEF_like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR041529; DUF5598.
DR InterPro; IPR041525; N/Namide_PRibTrfase.
DR InterPro; IPR016471; Nicotinamide_PRibTrfase.
DR InterPro; IPR036068; Nicotinate_pribotase-like_C.
DR PANTHER; PTHR43816; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43816:SF1; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; 1.
DR Pfam; PF18127; NAMPT_N; 1.
DR Pfam; PF04095; NAPRTase; 1.
DR PIRSF; PIRSF005943; NMPRT; 1.
DR SUPFAM; SSF51690; Nicotinate/Quinolinate PRTase C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:ABP76047.1};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABP76047.1}.
FT DOMAIN 6..108
FT /note="Nicotinamide phosphoribosyltransferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18127"
FT DOMAIN 183..451
FT /note="Nicotinate/nicotinamide phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF04095"
SQ SEQUENCE 490 AA; 55076 MW; B74550947449193F CRC64;
MYLNPVTAID GYKVDHRRQY PDNTQVIFSN LTARKSRRGY TDQMVFFGLQ YFIKHFLIDS
WNRDFFQQPK EQVIRQFSRR INNYLGPNNV GTQHIEELHD LGYLPIKIMA LPEGSVYPLK
VPCLILYNTD ERFFWLTNYL ETILSANVWG MCTSATTALQ YRKIFETYAL ETDGDIAFVD
WQGHDFSFRG MYGAEAAIMS GAAHLLSFTG TDTIPAIDFL EQYYLADSDK ELVGGSVAAT
EHSVMCAGGM ENELETFRRL IEDIYPTGIV SIVSDSWDFW QVMTEFTLAL KDRILARDGK
VVFRPDTGCP VKIICGDPQA PIGSPEYKGA IECLWDVFGG STTAKGYKAL NSHVGLIYGD
SITIERAEAI CAGLKAKGFA STNIVFGIGS FTYQHVTRDT DGYAVKATFA KVDGKDREIF
KDPKTDDGTK KSAKGLVAVF KDEQGQFYLK DQASWQDVNN CEFVPVFADG ELLTEYSLAD
IRARLAESRS
//
