ID A4YI81_METS5 Unreviewed; 314 AA.
AC A4YI81;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=3-hydroxypropionate dehydrogenase (NADP(+)) {ECO:0000313|EMBL:ABP96133.1};
GN OrderedLocusNames=Msed_1993 {ECO:0000313|EMBL:ABP96133.1};
OS Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509
OS / TH2).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Metallosphaera.
OX NCBI_TaxID=399549 {ECO:0000313|EMBL:ABP96133.1, ECO:0000313|Proteomes:UP000000242};
RN [1] {ECO:0000313|EMBL:ABP96133.1, ECO:0000313|Proteomes:UP000000242}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2
RC {ECO:0000313|Proteomes:UP000000242};
RX PubMed=18083856; DOI=10.1128/AEM.02019-07;
RA Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.;
RT "The genome sequence of the metal-mobilizing, extremely thermoacidophilic
RT archaeon Metallosphaera sedula provides insights into bioleaching-
RT associated metabolism.";
RL Appl. Environ. Microbiol. 74:682-692(2008).
CC -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009463}.
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DR EMBL; CP000682; ABP96133.1; -; Genomic_DNA.
DR AlphaFoldDB; A4YI81; -.
DR STRING; 399549.Msed_1993; -.
DR KEGG; mse:Msed_1993; -.
DR eggNOG; arCOG00251; Archaea.
DR HOGENOM; CLU_009834_0_1_2; -.
DR BioCyc; MetaCyc:MONOMER-13727; -.
DR BRENDA; 1.1.1.298; 7245.
DR Proteomes; UP000000242; Chromosome.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF1; LAMBDA-CRYSTALLIN HOMOLOG; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00067; 3HCDH; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Reference proteome {ECO:0000313|Proteomes:UP000000242}.
FT DOMAIN 4..183
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 187..271
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 314 AA; 35320 MW; AB597469F56ECE48 CRC64;
MTEKVSVVGA GVIGVGWATL FASKGYSVSL YTEKKETLDK GIEKLRNYVQ VMKNNSQITE
DVNTVISRVS PTTNLDEAVR GANFVIEAVI EDYDAKKKIF GYLDSVLDKE VILASSTSGL
LITEVQKAMS KHPERAVIAH PWNPPHLLPL VEIVPGEKTS MEVVERTKSL MEKLDRIVVV
LKKEIPGFIG NRLAFALFRE AVYLVDEGVA TVEDIDKVMT AAIGLRWAFM GPFLTYHLGG
GEGGLEYFFN RGFGYGANEW MHTLAKYDKF PYTGVTKAIQ QMKEYSFIKG KTFQEISKWR
DEKLLKVYKL VWEK
//
