ID A4ZZ89_MONDO Unreviewed; 3337 AA.
AC A4ZZ89;
DT 29-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2007, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=BRCA2 {ECO:0000313|EMBL:ABP48762.1};
DE Flags: Fragment;
GN Name=brca2 {ECO:0000313|EMBL:ABP48762.1};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|EMBL:ABP48762.1};
RN [1] {ECO:0000313|EMBL:ABP48762.1}
RP NUCLEOTIDE SEQUENCE.
RA Tavtigian S.V., Babikyan D., Voegele C., Samollow P.B.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; EF508680; ABP48762.1; -; mRNA.
DR SMR; A4ZZ89; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR CDD; cd04493; BRCA2DBD_OB1; 1.
DR CDD; cd04494; BRCA2DBD_OB2; 1.
DR Gene3D; 6.10.70.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR048262; BRCA2_OB_2_dom.
DR InterPro; IPR015188; BRCA2_OB_3.
DR InterPro; IPR002093; BRCA2_repeat.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR015205; Tower_dom.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 1.
DR Pfam; PF09104; BRCA-2_OB3; 1.
DR Pfam; PF00634; BRCA2; 8.
DR Pfam; PF21318; BRCA2DBD_OB2; 1.
DR Pfam; PF09121; Tower; 1.
DR PIRSF; PIRSF002397; BRCA2; 1.
DR SMART; SM01341; Tower; 1.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF81878; BRCA2 tower domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR PROSITE; PS50138; BRCA2_REPEAT; 8.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2817..2858
FT /note="Tower"
FT /evidence="ECO:0000259|SMART:SM01341"
FT REGION 701..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1353..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2415..2447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3215..3241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2838..2865
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1354..1373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1374..1392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2415..2431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2432..2447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3216..3230
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 3337
FT /evidence="ECO:0000313|EMBL:ABP48762.1"
SQ SEQUENCE 3337 AA; 375502 MW; 51F92A8D466EC9FE CRC64;
MSAGYQGKTT FFEVFKTRCS ESDLGPISLN WFEELTSEAP PYNYEISEDP GSKTEITEVN
YFKTPQRKPF TYNQLASTPL IFKEQNVNCS LNSSPLSGPD HCKLDLGKDT AMDKELRKSH
CVLKTKLGQA NDVTSPPLST CLSESPAVLR GAYRTPQREK PVAYGNLLYT PKLMKVNTPK
HISESLGAEV DPDMSWSSSL ATPPTLSSTV LIVRDGQTPG ARTPDDTTIM LQKYLSQHGE
RPKRLDRSTS SVPNIENIHA EGYGTSQELE KMIDDSFDDG NNFKDHGGKM INMPNIMEEE
ICDPIINTPV EDDASFNFTG YIVGNLRKVK CDKTRKKYSK TKTNEYEDTK NLSKKENYSS
ASETELEYCY PLISKAENNE IQKSIKNVNE EMLEDDVPSS ATQWSQLNLS GLDVTQIEKT
PLPHISFCVQ NSEERPANES NECSSLSTLK TVEIAAYKED EEKITTPNKG SVMLLKQISP
EISPPNAISQ DRKNSKFKMR QTSEETVSMD FLECSSLCTV NASITTEAKV FENKLENPKS
SLDDIICPEK HGLLSPNTDG KGSCATVSKR NSAPLNSTGI ISHFKKRTKK FIYVVNNDSS
YQGEKIQKTQ EFGSVNCSAS SHLELNSFEE HHEFTNAISD FLDSSIRRKC SQFDPKEETA
PLTECDKTMM EEYFHESRFP HNEVTSQDLG FREVEMNKGE LESDITETDN QSQSQERSYN
DFSKRQRDSH VKECILTATC LSPRKHTEIE LGNIAENSHF TTKNSTLHDS VDTSINSLTQ
LPQDPQELSV VIYGKKEPLC KVKQKLRFRR NSDSTFITNK VRSELKESFG NKGNQETEVL
NEILGDDREL SSEKCKEMTS VSLGAQVNKN AGLFVSLRDQ ENTNLITEKT AIELYSEENL
HFNEENFIFQ TIDKKNIRVT DSSEEFFATS FCYLEESIPK NSTEIDYKQT VQELFMEDSF
SSEMVPVFTR DSQDKNQNSK LACECISQSK SSYSKSTIDT NMKPKRNEEN YLGKWAQNFD
PDSNKSFGCG FKTASNKEII LSEHNIKKGK LFFKDIEQYY NSSSVEVVNS SISVAAENIK
TDSDSKKQEK NSFPAWKSEP SHIISKDVQS NIFVLNEKEI DPALEDLCSE KDLDLNHSLT
ASQKAEITEL STILEETGSQ FEFTQFRKQS STVQTLDIST NKADELGNLN TFELQMGVEL
GDHFGAEYET DNNRSPVQVD LNVNSEVVIN VKQRTVYLPK SNSEQGASTD IFTESEFKGF
CSALGRKMNV SNEALQKAMK LFSDIEEIGE GTPLQNLRNG PLDRSQKSNI VPAFKIANYA
NNSKDFKGKD AKPQSNAENN TGIFVEENML NCSRDPENKQ SSSPLFISSH KDSSKLKGSV
EPDSDNSQRE KNDLSSIDQQ NYPKMSIQLI RQENYPVKGG LLDLNCLGKA VKDEKIFASN
VSGIEELVSN QEEQKMRENE NSSHLQSFQT ASGRNIMVSK DSFSKVAHLF AEECSVKELN
DFSFPFTLKM LNTALNKSVE SSGKKSENLA ENEIEEMAVA TKKELMPIQK GPKIENKKWK
EYNMVGFHTA SGKEVTISKE SLTKVKHFFV EENLENDVTN IKNLETEFLN EREKINEKLV
QAYEMVKLNN SQVCEEMQSF QDNDEKVLPV RTTDLPKITD SILSNEPSNN VLFEEKLSEI
KENCILSDAK QSTGLPVEMS GLGFYTGHGK SVPVSETSLL EARKWLKEID LGGKTKASGM
FVSSVDVKED SDIHVKKSVP LYTSNNTSSI DDKNISDKQD AVFLSNSMSS IKHNLKHDTE
GSDFCHSNDA DFFSEHISDK VMSCLKAQPP AFTTASGKTV HISNEAVQKA REMFINNGDK
FLKPNIENKS ENNQMKNVKD PSKILENKDI SPKSFDGKKR NLSVNEGSFS NKIYSKKAQL
ENISAGIALE MDSEVSHCQI NSKTSDLYKS TIGKQPKGSS SVGIFCTANG KPVQVSDNSL
KKARQVFSEI ANDSEQLLSI KGSESHPETL IGEENAMLYA KINLPAQKDY LSNMQNLYNN
SGFNTASGKQ VLISESALQK VKGMLVEFDL MRNECLESIQ DVTPKGLSPV LCIEGSETPK
HIVNSKSKEI CNKELHFSNN CNVEISSSEN SRIIEVSCAQ FKQDMIHPLL ETKLTPAKEI
SFLKKGQVGL KDVDMESSEA IDGLPVKRNL QVSSPNSKAQ ETSMEREAVE IAKAFMQDDE
FTDSELPHNA KKSFFTYKNN EERILTNSRF GKRRMEERAS YGEPPIKRKL LYEFDRAVEN
QAKSLKPSKS SPDGTMKDRR KLMHHISLKP VTCDPFSTAK EWRQMRYPNF TAPGQELASK
YHFLKHQTLE NSSHNLLLQS PSYKDSSTDN GKVKSISVRG KPAKVFVPPF KTNSNSSTAT
DDEFVRKRLK VKVKEYTPEN EKQKYGDAHN SGDSENNENY LSDKDNSNQA TTDIFKECGN
LHLEMIENLQ HAREMQDMRI KKKQTQKIHP QAGSLYLRKT STLPRSSLRV VVEGKVPSTY
SSKQLYMYGI TKQCLKINSK NSESFKFHSE DYFSKEHLLD GNGIQLADGG WLIPTDEGKL
GKEEFYRALC DTPGVDPKLI TKTWVYNHYR WIIWKLAAME FTFPKEFASR CLTPEWVLLQ
LKYRYDIEID ESRRSAIKKI MERDETPAKT LVLCVSEIIS SGTNISITAN SKNNSVETKK
ESAVIEVTDG WYAIKALLDS SLLAILQKGK LTTGQKIITH GAELIGSQEA CTPLEAPESL
MLKLSANSTR PARWYAKLGF FSDPRPFPLP LSSLFSEGGN VGCVDIVVQR VYPTQWMEKT
LSGSYIFRNE RAEEKEALKY AECQQKKLEA LLTKIQAEFE KHEENSATQH RQSHILTRQQ
VRALQDGADL YEAVKNAPDP AYVEGCFSKE QLRTLNHHRQ ILNDKKQEQL QAEFRKAIAA
AELEEHGLAK RDVTTVWKLR VVNYKKHEKD SVILSIWRPL SDIYALLKEG NRYRIYNLAT
SPSKSKSDRA HIRLTATKKT QYQQLPVSHE ALSQVYQPRE AVPLDKLMEP SFRPLCAEVD
VVGVVISVTK KPGVAPLVYL SDEYYNLLAV KFWIDLNEDV IKLHTLIAAS NLQWKTESRA
GIPMLFAGEF SVFSASPKQS HFQERFNKLK NSVENIDLFC DGAEKKLSHL LDTHNSKQPN
AVREYNLDSP SPQAKLGLGP MISPFHREPN HHCPEGNSGA TISSVKISPT SDCRGDRKMD
DPKICKKRRS LDFLSRLPLP PPISPIRTFV SPAAQKAFQP PRSCGNKYNV PVKKNTSNSP
QMTIKTLSGT TMAENDLIAD EELALINTQA LLPNSSE
//
