ID A5A8X3_PIG Unreviewed; 1994 AA.
AC A5A8X3;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 131.
DE SubName: Full=Neurogenic locus notch homolog protein 4 preproprotein {ECO:0000313|EMBL:HDB24143.1};
DE SubName: Full=Notch homolog 4 (Drosophila) {ECO:0000313|EMBL:CAN13256.1};
GN Name=NOTCH4 {ECO:0000313|EMBL:CAN13256.1};
GN ORFNames=SBAB-649D6.4-001 {ECO:0000313|EMBL:CAN13256.1};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:CAN13256.1};
RN [1] {ECO:0000313|EMBL:CAN13256.1}
RP NUCLEOTIDE SEQUENCE.
RA Sehra H.;
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDB24143.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AL773562; CAN13256.1; -; Genomic_DNA.
DR EMBL; DQIR01168666; HDB24143.1; -; Transcribed_RNA.
DR EMBL; DQIR01300074; HDC55552.1; -; Transcribed_RNA.
DR RefSeq; NP_001116619.1; NM_001123147.1.
DR GeneID; 100144522; -.
DR KEGG; ssc:100144522; -.
DR CTD; 4855; -.
DR HOGENOM; CLU_000576_0_0_1; -.
DR OrthoDB; 5473534at2759; -.
DR TreeFam; TF351641; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 17.
DR CDD; cd21705; JMTM_Notch4; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 26.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022355; Notch_4.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF498; PROTEIN EYES SHUT HOMOLOG-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00008; EGF; 13.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF12661; hEGF; 4.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 3.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01987; NOTCH4.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00181; EGF; 29.
DR SMART; SM00179; EGF_CA; 22.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 11.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF90193; Notch domain; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS00010; ASX_HYDROXYL; 9.
DR PROSITE; PS00022; EGF_1; 27.
DR PROSITE; PS01186; EGF_2; 20.
DR PROSITE; PS50026; EGF_3; 27.
DR PROSITE; PS01187; EGF_CA; 3.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1994
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5036278874"
FT DOMAIN 23..62
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 63..114
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 117..153
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 154..190
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 192..230
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 232..272
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 274..310
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 312..351
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 353..389
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 390..428
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 430..471
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 473..509
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 511..547
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 549..585
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 587..623
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 689..725
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 727..763
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 765..801
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 804..840
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 842..878
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 891..926
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 928..964
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 966..1002
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1004..1042
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1044..1083
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1085..1124
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1128..1169
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1168..1211
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1212..1248
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1249..1282
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1631..1663
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1664..1686
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1698..1730
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1731..1763
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1764..1796
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1344..1372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1884..1903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1909..1932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1963..1994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 453
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 456
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 473
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 476
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 490
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 512
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 514
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 528
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 52..61
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 104..113
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 121..131
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 143..152
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 180..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 220..229
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 262..271
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 300..309
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 341..350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 379..388
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 399..416
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 418..427
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 434..450
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 444..459
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 461..470
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 477..488
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 482..497
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 499..508
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 515..526
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 520..535
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 537..546
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 575..584
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 613..622
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 715..724
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 753..762
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 791..800
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 830..839
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 868..877
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 916..925
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 954..963
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 992..1001
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1013..1030
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1032..1041
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1073..1082
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1114..1123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1159..1168
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1994 AA; 208206 MW; 6A2EC9F6CBABFD49 CRC64;
MRPPSLLLPP LLLLLCRPVV QSRGLQCGSF PGPCANGGTC LSPPQGQGTC QCAPGFLGET
CQFPDPCQDA QLCQNGGSCQ ALLPTLPGST SPPSPLTPSF FCTCPFGFTG ERCQAQVKDP
CSSFCSKMGR CHIEASGRPR CTCMPGWTGE QCQHRDFCSA NPCVNGGVCL ATYPQIQCHC
PPGFEGHTCE HDVNECFLNP GPCPKGTSCY NTLGSFQCLC PVGRDGPRCE LQPGPCPPRG
CLNGGTCQLV PGRDSTFHLC LCPPGFTGAS CEVNPDDCVG HQCQNGGICQ DGLGTHTCLC
PEAWTGWDCS EDVDECEAQG VPRCRNGGTC QNSAGSFHCV CVSGWGGTDC EENLDDCAAA
TCAPGSTCID RVGSFSCLCP PGRTGLLCHM EDMCLSQPCH GEAQCSTNPL TGSTLCLCQP
GYTGPTCHQD LDECQMAQQG PSPCEHGGSC LNTPGSFECL CPPGYTGSRC EADHNECLSQ
PCHPGSTCLD LLATFHCLCP PGLEGRLCEV ETDECASAPC LNQADCHDLP NGFRCVCQPG
FTGPRCEEDI NECRSSPCAN GGQCQDQPGS FHCECLPGFE GPRCQTEVDE CLSSPCPSGA
SCLDLPGAFL CLCPSGFTGH LCESPLCAPN LCQSKQKCQD QEDKAHCLCP DGSPGCAPAE
DNCTCHHGHC QRSSCVCDVG WTGPECDAEL GGCISTPCAH GGTCHPQPFG YNCTCPTGYT
GPTCREEVTA CHSAPCLNGG SCSPSPGGYS CTCPPSHTGL HCQTSIDHCA SAPCLNGGTC
VNRPGAPSCL CAPGFQGPRC EGRVRPSCAD SPCRNRATCQ DGPQGPRCLC PPGYTGGSCQ
TLMDFCAQKP CPRNSRCLQT GPSYQCLCLQ GWTGPLCNLP LSSCQKAALS QGAEVSSLCQ
NGGICVDNGP SYFCHCSPGF QGSMCQDRVH PCESRPCQHG ATCVAQPNGY LCQCAPGYSG
QNCSEEPDAC QSQPCHNHGT CTPKPGGFHC ACPPGFVGLR CEGDVDECLD RPCHPTGTAA
CHSLANAFYC QCLPGHTGQW CEVEIDPCQS QPCSHGGSCE TTAGPPPGYT CHCPQGFEGP
TCSHRAPSCG LHHCHHGGLC LPSPKPGFPP RCACLNGYGG PDCLTPPTPP GCGPPSPCLH
NGSCSETPGL GGPGFRCSCP PSSPGPRCQR PGAKGCEGRG GDGACDAGCS GPGGNWDGGD
CSLGVPDPWK GCPSHSRCWL LFRDGQCHPQ CDSEECLFDG YDCETPPTCT PAYDQYCRDH
FHNGHCEKGC NTAECGWDGG DCRPEDGGSE WGPSLALLVV LSPATLDQQL LALARALSLT
LRVGLWVRKD SDGRDMVYPY PGAQAEEELG GTPDPSHQER AAPQTQPVGK ETDSLSTGFV
VVMGVDLSRC GPDHPASRCP WDPGLLLRFL AAMAAVGALE PLLPGPLLAA HPRAGTAPPA
NQLPWPVLCS PVAGVLLLAL GALLVLQLIR RRRREHGALW LPPGFTRKPR SQAVPRRRRP
PLGEDSIGLK ALKPEAEVDE DGVVMCSGPE EGEEVGQAEE MASPSKCQLW PLSADCQELP
QAAMLTPPQD SEVDIPDVDT RGPDGVTPLM SAVCCGGVES RTYQETWLGS PEPWEPLLGG
GACPQVHTVG TGETPLHLAA RFSRPTAARR LLEAGANPNQ PDRAGRTPLH TAVAADAREV
CQLLLRSRQT AVDARTEDGT TALMLAARLA VEDLVEELIA ARADVGARDK WGKTALHWAA
AVNNSRAARS LLQAGADKDA QDGREQTPLF LAAREGAVEV AQLLLGQGAA RGLRDQAGLT
PGDIARQRNH WDLLTLLEGA GPPEARHKAT PGRGVGTFQR ARTASGSVLP RGGGALPRCR
TLSAGACPQA RTLSVDLAAH GGGAYSHGRS LSKGGAGGGP PLRGRRFSAG MRGPRPHPAI
VRGRSGVTAG SGGVASGDHW PCDWVALDSC GPASSTPIPP PCLTPSPERA SPQVAWGPPA
HQVIPLNAGG EGQK
//
