ID   A5AXV6_VITVI            Unreviewed;       790 AA.
AC   A5AXV6;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=Disease resistance protein RGA3 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=VITISV_034289 {ECO:0000313|EMBL:CAN60718.1};
OS   Vitis vinifera (Grape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; Vitales; Vitaceae; Viteae; Vitis.
OX   NCBI_TaxID=29760 {ECO:0000313|EMBL:CAN60718.1};
RN   [1] {ECO:0000313|EMBL:CAN60718.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA   Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA   Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA   Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA   Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA   Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA   Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA   Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA   Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA   Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT   "The first genome sequence of an elite grapevine cultivar (Pinot noir Vitis
RT   vinifera L.): coping with a highly heterozygous genome.";
RL   PLoS ONE 2:e1326-e1326(2007).
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DR   EMBL; AM439590; CAN60718.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5AXV6; -.
DR   EnsemblPlants; Vitvi03g00603_t001; Vitvi03g00603_P001; Vitvi03g00603.
DR   Gramene; Vitvi03g00603_t001; Vitvi03g00603_P001; Vitvi03g00603.
DR   ExpressionAtlas; A5AXV6; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR   Gene3D; 1.20.5.4130; -; 1.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039203; RGA2/3-like.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR36766:SF38; NB-ARC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF18052; Rx_N; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        731..750
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          12..96
FT                   /note="Disease resistance N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18052"
FT   DOMAIN          172..372
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000259|Pfam:PF00931"
FT   COILED          35..62
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   790 AA;  90893 MW;  F9B51B3E1EB8F26B CRC64;
     MEVEILAILA ELVLEKWAAK TWEQIELAWN VESQRLKLQK TVSALKELLL EAEQRKNQGR
     QQLRDWLGEL TDALYDADNV LDEFHYHSLQ RQVESRGGIV EGTVRRSFFT FTEPTFSYKM
     GRKIKKIRKT LDDIAADWSR LCLPELGVDM GIVQRDQSHS YADPSNVIGR DHDKNVVIQH
     LRLWTETLSV IPIVGIEGIG KTTVAQLVYN DPWVAAHFEL RMWVCVSKDF DVERLIKQII
     DSAEGGNCGE VSMDEAQIRL RSVLMEKRFL LILDDVWNND RGRWLDLELF LREGEADSKI
     IVTTQSRSSV AAVMGTVPMH ELSHLSFEDS LSLFTNLAFD NRVQERLPSL ESIAQEIVER
     CGGVPQLLKT TACSLYSITE QHIWFSKRDT ALKLRLDGLP SALRQCLALC SIFPTNFRFY
     SLRLNQLLMA QDFITLSHPN EDLEDAGHQY MDILYSRCVF QNREQDYGDF FYVQIHNLIH
     DHAWEAAQPE YTVLNFHRNA HPPQTNIRHV SLSEDEWPAA EGVLDVLRAL GRANKVRTIL
     CPFVRVQTID EPFISAFIER FKYMRVLDLS YSCFERLPES ISDLIHLRLL SLRSNIRIRR
     LPNSICKLYN LQTLVLLDCC ELEELPRDTK NMISLRHLEI TTKQSTFPEL YDSNSLRFLG
     IVGCISLRSL LREGQSFPAL RTLFIHSCGS LVSLLPSIRN LTALRTLKIA DCEALDLLDG
     DDDRFPGFQT LWFLVIVNLP MLVGLPQWIL RTATSNFLQR VVIEACPNFT GLPLAVQQNI
     TIRQKFKTRE
//