ID   A5BRX9_VITVI            Unreviewed;      1194 AA.
AC   A5BRX9;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN   ORFNames=VITISV_035077 {ECO:0000313|EMBL:CAN83518.1};
OS   Vitis vinifera (Grape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; Vitales; Vitaceae; Viteae; Vitis.
OX   NCBI_TaxID=29760 {ECO:0000313|EMBL:CAN83518.1};
RN   [1] {ECO:0000313|EMBL:CAN83518.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA   Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA   Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA   Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA   Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA   Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA   Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA   Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA   Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA   Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT   "The first genome sequence of an elite grapevine cultivar (Pinot noir Vitis
RT   vinifera L.): coping with a highly heterozygous genome.";
RL   PLoS ONE 2:e1326-e1326(2007).
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DR   EMBL; AM468841; CAN83518.1; -; Genomic_DNA.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   CDD; cd00303; retropepsin_like; 1.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 3.30.70.270; -; 3.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041373; RT_RNaseH.
DR   PANTHER; PTHR45835:SF105; IPP TRANSFERASE; 1.
DR   PANTHER; PTHR45835; YALI0A06105P; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   Pfam; PF08284; RVP_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   SUPFAM; SSF54160; Chromo domain-like; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
FT   DOMAIN          826..999
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          126..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1194 AA;  137367 MW;  135F370DE1353E90 CRC64;
     MPLRRPVSSQ NSQTNDDIRP PSEVLPPMST EGLYRYLGTL VGLVEYQARA IGSNGQGQSS
     STRGSSFDYF KKLGPPYFYE EEKALKFQDG LKSYLKNKIS IMKLSVYSEV VDRALIVEKD
     NEELHQYREQ QRKRNINDGA HGNQAQKKPA PRTYGSGLSK ENKKFVFRKP KEENKEDRQK
     LRAQGRVFAM THRDAQTTFD VVIGTLQIHT LFARALIDPG STHSFVSVSF AGLLGMSIDN
     MDFDLFVAIP LGDSVVVNKI LRDCIVMIGY REMTVDLVLL DLQDFDVILG MNWLASYHAS
     IDCFGKIVTF NIPSRPDFGF EGKHVDKPLH MISALQASSL LRKGCQGFLA YVMNEENNLK
     LEDIPIVRDY PDVFPDDLPG LPPEKEVEFT IDVALGTTPI SKAPYRMAPL ELKELKIQLQ
     ELLDKGFIRP SVSPWGAPVL FVKKNDGSMR LCIDYRELNK VIVRNKYPLP WIDDLFDQLQ
     DACVFSKIDL RSGYHQLRIR SEDVPKIAFR TRYGHYEFLV MSFGLTNAPA AFMDLMNRSR
     DEHERYLSIV LQTLRDKQLY AKLKKCELWL DKVSFLGHVR PNNVTEIRSF LGLASYYRQF
     IEGFSKIALP LTRLTKKGVK FEWSNDCERS FQELKNILVT TPILTISLGS GGQLKPYERN
     YLTHDLELAT VVFALKIWRH FLFGETCEIF TDHKSLKYLF SQKELNMRQR RWIELLKDYY
     YIIQYHLGKV NIVADALNRK FVGSLAAIRG CQRQLLEDLR CLQVHMRFLD SGALVANFKV
     QPDLVGRIKA LQKKDLNLVQ LMEEVKNGNK PDFVLLDDGI LRFRVRLCVP NDGDLKRELL
     EEAHCSRLAI HPGGTKMTLG GNNAIWVIVD RLTKSAHFLP MKVNFSMDRL TSLYIKDIMR
     MNDVPVFIVS NRDPRFTSRF CHSLQKALGT KLSFSTAFHP QIDDQSERVI QVLEDLLRAC
     ALDLKGNWDD YLPLVEFAYN NSFQASIGMT PFEALYGRRC RSLLTIEKVS LIKERLKTAQ
     SRRKSYANNC RRDLEFXVGD HVFLKVSPMK SIMRFGRKGK LSPRFVGPFE VLERVGTLAY
     KVALPPSLSK IHNVFHVSTL RKYIYDPFHV VELEPIQISE DLTYEEVPVQ IVDVMDKVLR
     HDVVKLVKVQ WSNHSIREAT WELEEEMREK HPQLFQDSGM SNLEDQTFVK EGRM
//