ID   A5C4T5_VITVI            Unreviewed;      1160 AA.
AC   A5C4T5;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=VITISV_006137 {ECO:0000313|EMBL:CAN81820.1};
OS   Vitis vinifera (Grape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; Vitales; Vitaceae; Viteae; Vitis.
OX   NCBI_TaxID=29760 {ECO:0000313|EMBL:CAN81820.1};
RN   [1] {ECO:0000313|EMBL:CAN81820.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA   Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA   Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA   Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA   Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA   Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA   Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA   Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA   Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA   Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT   "The first genome sequence of an elite grapevine cultivar (Pinot noir Vitis
RT   vinifera L.): coping with a highly heterozygous genome.";
RL   PLoS ONE 2:e1326-e1326(2007).
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DR   EMBL; AM482334; CAN81820.1; -; Genomic_DNA.
DR   CDD; cd00303; retropepsin_like; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR005162; Retrotrans_gag_dom.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR24559:SF433; RNA-DIRECTED DNA POLYMERASE; 1.
DR   PANTHER; PTHR24559; TRANSPOSON TY3-I GAG-POL POLYPROTEIN; 1.
DR   Pfam; PF13650; Asp_protease_2; 1.
DR   Pfam; PF03732; Retrotrans_gag; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE   4: Predicted;
FT   DOMAIN          94..187
FT                   /note="Retrotransposon gag"
FT                   /evidence="ECO:0000259|Pfam:PF03732"
FT   DOMAIN          934..1078
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|Pfam:PF00078"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          388..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          435..480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        436..480
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1160 AA;  132266 MW;  FD93F426BE26AC4C CRC64;
     MEATPEDQHS HQGRQXNLNE FRSMRDRMHP PRMSAPSCIV PPTEQLVIXP YLVPLLPTFH
     GMESENPYAH IKEFEDVCNT FQEGGASIDL MRLKLFPFTL KDKAKIWLNS LRPRSIRSWT
     DLQAEFLKKF FPTHRTNGLK RQISNFSAKE NEKFYECWER YMEAINACPH HGFDTWLLVS
     YFYDGMSSSM KQLLETMCGG DFMSKNPEEA MDFLSYVAXV SRGWDEPTKG EVGKMKSQLN
     AFNAKXGMYT LKEDDDMKAK LAAMTRRLEE LELKRIHEVQ AVAEAPVQVK LCPNCQSYEH
     XVEXCPAISA EREMXRDQAN VVGQFXPNNN AXYGNTYNSS WRNHPNFSWK ARATQYQQPD
     SPSQQSSSLE QAMANLSKYS ISRLTNLNTL QEKGRFPSQP HQNPKGVHEV ESQEGESSQM
     KDVKALITLR SGKKIEQPTP KPHVEKEEEI KKGKEMEDKE SEISEEKKDS DSTMNAIPEK
     EFMKEKMLKK STSLPFPQAL HGKKGIRNAA EILEVLRQVK VNIPLLDMIK QVPTYAKFLK
     DLCTIKRGLT VNKKAFLTEQ VSAILQCKSP LKYKDPGSPT ISVMIGEKVV EKALLDLGAS
     VNLLPYSVYK QLGLGELKPT AITLSLADRS VKIPRGVIKD VLVQVDNFYY PVDFIVLDTD
     PTVKEANLVP IILGRPFLAT SNAILNCRNG LMQLTFGNMT LDLNIFYMSK KQITPEEEEG
     PEELCIIDTL VEEHCNQNMK DKLNESLVNF EEGLSESPTM LATLQSWRKI EEILPLFNKE
     EEAVAETEIP KLNLKPLPVE LKYTYLEENN QCPVVISSSL TSHQENCLMK VLKRCKKAIG
     WQISDLKGIS PLVCTHHIYM EEETKPIRQF QRRLNPHLQE VVRAEVLKLL QARIIYPISD
     SPWVSPTQVV PKKSGITVVQ NEKGEEVTTR LTLGWRVCID YRKLNAITRK DHFPLPFIDQ
     VLERVSGHPF YCFLDGYSGY FHIEIDLADQ EKTTFTCPFG TYAYRRMPFG LCNAPATFQR
     CMLSIFSDMV ERIMEVFMDD ITVYGGTFEE CLVNLEAVLH RCIEKDLVLN WEKCHFMVKG
     SYKRGEVPYA KTELRSFGSF SRIRELTYSQ FSNRCCTDLK RPPLPSGCEI SGEGGMSAGQ
     NSSPGGMSYA ARLMGDRLRV
//