ID A5C652_VITVI Unreviewed; 1746 AA.
AC A5C652;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN ORFNames=VITISV_019688 {ECO:0000313|EMBL:CAN66393.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CAN66393.1};
RN [1] {ECO:0000313|EMBL:CAN66393.1}
RP NUCLEOTIDE SEQUENCE.
RA Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT "The first genome sequence of an elite grapevine cultivar (Pinot noir Vitis
RT vinifera L.): coping with a highly heterozygous genome.";
RL PLoS ONE 2:e1326-e1326(2007).
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DR EMBL; AM483682; CAN66393.1; -; Genomic_DNA.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR005162; Retrotrans_gag_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF13650; Asp_protease_2; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF03732; Retrotrans_gag; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 4: Predicted;
FT DOMAIN 1457..1635
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT REGION 348..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1746 AA; 200704 MW; 468FD78D891F1F6D CRC64;
MEATPEDQHS HQGLQDYLNE FRSMRDRMHP PRMSAPSCIV PPTEQLVIRP YLVSLLPTFH
GMESENPYAH IKEFEDVCNT FQEGGASIDM MRLKLFPFTL KDKAKIWLNS LRPRSIRSWT
DLQAEFLKKF FPTHRTNGLE RQISNFSAKE NEKFYECWER YMEAINACPH HGFDTWLLVS
YFYDGMSSSM KQLLETMCGG DFMSKNPEEA MDFLSYVAEV SRGWDEPTKG EVGKMKSQLS
AFNTKAGMYT LKEDDDMKAK LAAMTRRLEE LELKRIHEVQ AVAEAPVQVK LCPNCKSYEH
LVEECPAISA EREMFRDQAN VVGQFRPNNN APYGNTYNSS WRNHPNFSWK AXATQYQQPD
PPSQQSSKAT NAQINQRIDR VESILNKRMD GMQNDMNQKF DNIQYSISRL TNLNTLQEKG
RFPSQPHQNP KGVHEVESQE GESSQMKDVK ALITLRSGKK IEQPTPKPHV EKEEEIKKGN
EMEDKESEIS EEKKDSNSTM NAIPEKELLK EEMLKKSTSP PFPQALHGKK GIRNVAEILE
VLRQVKVNIP LLDMIKQVPT YEKILKDLCT IKRGLTVNKK AFLTEQVSAI LQCKSPLKYK
DSGSPTISVM IGGKVVEKAL LDLGASVNLL PYSVYKQLGL GELKPTXITL SLADRSVKIP
RGVIEDVLVQ VDNFYYPVDF IVLDTNPTIK EANLVPIILG RPFLATSNAI INCRNGLMQL
TFGNMTLDLN IFYMSKKQTT PEEEEGPEEL CIIDTLVEEH CNQNMQDKLN ESLVDFEEGL
SESPTVLATL QSWRKIEEIL PLFNKEEEAA AEKETPKLNL KPLLVELKYT YLEENNQCPV
VTSSSLTSHQ ENCLIEVLKR CKKAIGWQIS DLKGISPLVC THHIYMEEEA KSIRQLQRRL
NPHLQEVVRA EVLKLLQAGI IYPISDSPWV SPTQVVPKKS GITVVQNEKG EEITTWPHFR
KDHFPLPFIE QVLERVSGHP FYCFLDGYSG YFQIEIDVAD QEKTTFTCPF GTYAYRRMPF
GLCNAPATFQ RCMLSIFSDM VERIMEVFMD DITVYGGTFE ECLVNLEAVL HRCIEKDLVL
NWEKCHFMVR QGIVLGHIIS EKGIEVDKAK VELIVKLPSP TTVKGVRQFL GHAGFYRRFI
KGFSSLSKPL CELLAKDAKF IWDERCQNNF DQLKKFLTTT PIVRAPNWQL PFELMCDASD
FAIGAVLGQR EDXKPYVIYY ASKTLNEAQR NYTFTEKELL DVVFVLDKFR AYLLGSFIIV
FTDHSALKYL LTKQDAKARL IRWILLLQEF DLQIKDKKGV ENVVADHLSR LVIAHNSHPL
PINDDFPEES LMFLVKTPWY AHIANYLVTG EIPSEWNAQD RKHFFAKIHA YYWEEPFLFK
YCADQIIRKC VPEDEQQGIL SHCHENACGG HFASXKTAMK VLQSGFTWPS LFKDAHIMCR
SCDRCQRLGK LTKRNQMPMN PILIVELFDV WGIDFMGPFP MSFGNSYILV GVDYVSKWVE
AIPCEQNDHR VVLKFLKENI FSRFGVPKAI ISDGGAHFCN KPFEALLSKY GVKHKVATPY
NPQTXGQVEL ANREIKNILM KVLIRLFLAC LPIVLSMAKH AISLWQVEYK AWWAIKKLNM
DLIRAGEKRY LDLNEMEELR NDAYINSKVA KQRMKKWHDQ LISNKEFQKG QRFLLYDTRL
HIFPGKLKSR WIGPFIIHQV YANGVVELLN SNGKDTFKVN GYRLKPFMEP FKPEKEEINL
LEPQKA
//
