ID A5CBG5_VITVI Unreviewed; 2329 AA.
AC A5CBG5;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN ORFNames=VITISV_015351 {ECO:0000313|EMBL:CAN79899.1};
OS Vitis vinifera (Grape).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; Vitales; Vitaceae; Viteae; Vitis.
OX NCBI_TaxID=29760 {ECO:0000313|EMBL:CAN79899.1};
RN [1] {ECO:0000313|EMBL:CAN79899.1}
RP NUCLEOTIDE SEQUENCE.
RA Velasco R., Zharkikh A., Troggio M., Cartwright D.A., Cestaro A., Pruss D.,
RA Pindo M., FitzGerald L.M., Vezzulli S., Reid J., Malacarne G., Iliev D.,
RA Coppola G., Wardell B., Micheletti D., Macalma T., Facci M., Mitchell J.T.,
RA Perazzolli M., Eldredge G., Gatto P., Oyzerski R., Moretto M., Gutin N.,
RA Stefanini M., Chen Y., Segala C., Davenport C., Dematte L., Mraz A.,
RA Battilana J., Stormo K., Costa F., Tao Q., Si-Ammour A., Harkins T.,
RA Lackey A., Perbost C., Taillon B., Stella A., Solovyev V., Fawcett J.A.,
RA Sterck L., Vandepoele K., Grando S.M., Toppo S., Moser C., Lanchbury J.,
RA Bogden R., Skolnick M., Sgaramella V., Bhatnagar S.K., Fontana P.,
RA Gutin A., Van de Peer Y., Salamini F., Viola R.;
RT "The first genome sequence of an elite grapevine cultivar (Pinot noir Vitis
RT vinifera L.): coping with a highly heterozygous genome.";
RL PLoS ONE 2:e1326-e1326(2007).
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DR EMBL; AM489048; CAN79899.1; -; Genomic_DNA.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 2.
DR CDD; cd09274; RNase_HI_RT_Ty3; 2.
DR CDD; cd01647; RT_LTR; 2.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 3.30.70.270; -; 4.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR005162; Retrotrans_gag_dom.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF13650; Asp_protease_2; 2.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF03732; Retrotrans_gag; 1.
DR Pfam; PF17917; RT_RNaseH; 2.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 2.
DR SUPFAM; SSF50630; Acid proteases; 2.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
PE 4: Predicted;
FT DOMAIN 2089..2253
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT UNSURE 30
FT /note="I or L"
FT /evidence="ECO:0000313|EMBL:CAN79899.1"
SQ SEQUENCE 2329 AA; 266877 MW; 17D32EF449C55A4C CRC64;
MRDRMHSTSY ECTIMYSRPP TEQLVIRPYX VPLLTNXPXD GXIRPKFWLN SLRPRSIRTW
TDLQAEFLKK FFPTHRTNGL KRQISNFSAK ENEKFYECWE RYMEAINACP HHSFDTWLLV
SYFYDGVSSS MKQLLEIMCG GDFMSKNPEE AMDFLSYVAE VSRGWDEPTK EEVGKMKSQL
SAFNAKAGMY TLKEDDDMKA KLAAVTRRLE ELELKKVHEV QAVAEAPMQV KLCPNCQSYE
HLVEECPAIL TEREMFRDQA NVVGDFVGNQ EAINAQLNQR IDRVESTLNK RMDGMQNDIS
QKFDNLQYSI SRLTNLNTVQ EKGRFPSXPH QNPKGVHEVE VQEGESSQMK DVKALITLRS
ALHGKKGIRN ASEILEVLRQ VKVNIPQLDM IKQVPTYAKF LKDLCTIKRG LTVNKKVFLI
EQVSAILQCK SPLKYKDPGS PTISVMIGGK VVEKALLDLG ASVNLLPYSV XKQLGLGELK
PTTITLSLAD XSVKIPRGVI EDVLVQVDNF YYPVDFIVLD TDPTVKEANL VPIILGRPFL
ATSNAIINCR NGLMQLTFGN MTLDLNIFYM SKKQTTPEEE EGPEEVCIID TLVEEHCNQN
MQDKLNESLA DXEEGFSEPP NVLATLQSWR MIEEILPLFN KEEEAVAEKE TPKLNLKPLP
VELKYTYLEE NNQCLVVISS SLTSHQEKSL MEVLKRCKKA IGWQISDLKG ISPLVCTHHI
YIEEKAKPIH QLQRRLNPHL QEMVRAEVLK LLQVSPTQVV PKKSGITVVQ NEKGEEITTR
LTSGWRVCID YRKLNAVTRK DHFPLPFIDQ VLERVSGHPF YCFLDRRMSF GLCNAPATFQ
RCMLSIFNDM VERIMEVFMD DITVYGGTFE ECLINLQAVL HRCIEKDLVL NWEKCHFMVR
QGIVLGHIIS EKGIEVDKAK VELIVKLPSP TTVKGVRQFL GHAGFYRRFI KGFSSLSKPL
CELLAKDAKF TWDERCQNSF DQLKKFLTTP IVRAPNRQLP FELMCDASDF AIGVVLGQRE
DGKPYVIYYA SKTLNEAQRN YTTTEKELLA VVFALDKFRA YLVGSFIIVF TDHSTLKYLL
TKQDAKARLI RWILLLQEFD LQIKDKKGVE NVVADHLSRL VIAHNSHPLP INDDFPEIKK
GEEMEDKESE ISEKKKDYDS TMNAIPEKEL QKEEMLKKST SPPFPQALHG KKEIRNASEI
LEVLRQVKVN IPLLDMIKQV PTYAKFLKDL CTIKRGLTVN KKAFLTEQVS AILQCKSPLK
YKDPGSPTIS VMIGEKVVEK ALLDLGASVN LLPYFVYKQL GLDELKPTTI TLSLADRSVK
IPRGVIEDVL VQVDNFYYPV DFIVLDTDPT VKEANLVPII LGRPFLSTSN AIINCRNGLM
QLTFGNMTLD LNIFYMSKKQ TTPEEEEGPE EVYIIDTLVE EHCNQNMQDK LNESLVDFEE
SLSEPPNVLA TLQSWRRIEE ILPLFNKEEE LEENNQCPVV ISSSLTSHQE KSLLQVLKRC
KKAIGCQISD LKGISPLVCT HHIYIEEEAK PIRQLQRRLN PHLQEVVQAE VLKLLQAGII
YPISDSPWVS PTQVVPKKSG ITVVQNEKGE EITTRLTSGW RVCIDYRKLN AVTRKYHFPL
PFIDQVLERV SGHPFYCFLD GYSGYFHIEI DVEDQEKTTF TCPFGTYAYR RMPFGLCNAP
ATFQRCMLST FEECLINLEA VLHRCIEKDL VLIWEKCHFM VRQGIVLGHI ISEKGIEVDK
AKVELIVKLP FPTTVKGVRQ FLGHAGFYRR FIKGFSSLSK PLCELLAKDA KFIWDERCQN
SFDQLKKFLT TTPIVRAPNW QLPFELMCDA SDFAIGAVLG QREDGKPYVI YYASKTLNEA
QRNYTTTEKE LLAVVFALDK FRAYLVGSFI IVFTDHSALK YLLTKQDAKA RLIRWILLLQ
EFDLQIKDKK GVENVVADHF SRLVIAHNSY SLPINDDFPE ESLMFLVKTP WYAHIANYLV
TGEIPSEWNA XDRKHFFSKI HAYYWEEPFL FKYCADQIXR KCVPEDEQQG ILNHCHENAC
GGHFASQKTA MKVLQSGFTW PSXFKDAHIM CRSCDRCQRL GKLTKRNQMP MNPILIVELF
DVWGIDFMGP FPMSFGNSYI LVGVDYVSKW VEAIPCRKND HRVVLKFLKE NIFSRFGVPK
AIISDGGAHF CNKPFEALLS KYGVKHKVAT PYHPQTSGQV ELANREIKNI LMKVVNASRK
DWSIRLHDSL WAYRTXYKTI LGMSPYRLVY GKACHLPVEV EYKAWXAIKK LNMDLIRAGA
KRCLDLNEME ELRNDAYINS KVAKXRMKKW HDQLISNKEF XERTKSFTL
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