ID A5D8Q4_XENLA Unreviewed; 314 AA.
AC A5D8Q4;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Citrate transport protein {ECO:0000256|ARBA:ARBA00042640};
GN Name=LOC100049774 {ECO:0000313|EMBL:AAI41770.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI41770.1};
RN [1] {ECO:0000313|EMBL:AAI41770.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fat bodies {ECO:0000313|EMBL:AAI41770.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate(in) + citrate(out) = (S)-malate(out) + citrate(in);
CC Xref=Rhea:RHEA:72483, ChEBI:CHEBI:15589, ChEBI:CHEBI:16947;
CC Evidence={ECO:0000256|ARBA:ARBA00036668};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cis-aconitate(in) + citrate(out) = cis-aconitate(out) +
CC citrate(in); Xref=Rhea:RHEA:72475, ChEBI:CHEBI:16383,
CC ChEBI:CHEBI:16947; Evidence={ECO:0000256|ARBA:ARBA00036042};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + D-threo-isocitrate(in) = citrate(in) + D-threo-
CC isocitrate(out); Xref=Rhea:RHEA:72471, ChEBI:CHEBI:15562,
CC ChEBI:CHEBI:16947; Evidence={ECO:0000256|ARBA:ARBA00036585};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + maleate(in) = citrate(in) + maleate(out);
CC Xref=Rhea:RHEA:72491, ChEBI:CHEBI:16947, ChEBI:CHEBI:30780;
CC Evidence={ECO:0000256|ARBA:ARBA00036819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + phosphoenolpyruvate(in) = citrate(in) +
CC phosphoenolpyruvate(out); Xref=Rhea:RHEA:72487, ChEBI:CHEBI:16947,
CC ChEBI:CHEBI:58702; Evidence={ECO:0000256|ARBA:ARBA00036159};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + succinate(in) = citrate(in) + succinate(out);
CC Xref=Rhea:RHEA:28835, ChEBI:CHEBI:16947, ChEBI:CHEBI:30031;
CC Evidence={ECO:0000256|ARBA:ARBA00036264};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=citrate(out) + trans-aconitate(in) = citrate(in) + trans-
CC aconitate(out); Xref=Rhea:RHEA:72479, ChEBI:CHEBI:15708,
CC ChEBI:CHEBI:16947; Evidence={ECO:0000256|ARBA:ARBA00035792};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; BC141769; AAI41770.1; -; mRNA.
DR RefSeq; NP_001092179.2; NM_001098709.1.
DR AlphaFoldDB; A5D8Q4; -.
DR GeneID; 100049774; -.
DR KEGG; xla:100049774; -.
DR CTD; 100049774; -.
DR OrthoDB; 5473154at2759; -.
DR Bgee; 100049774; Expressed in neurula embryo and 19 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR InterPro; IPR049563; TXTP-like.
DR PANTHER; PTHR45788; SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED; 1.
DR PANTHER; PTHR45788:SF4; TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT REPEAT 26..114
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 125..211
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 221..306
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 314 AA; 34055 MW; 5A5FB13782A149F5 CRC64;
MGSPVAVPVG ARSLAAAAPA GGSKLTHPGK AILAGGIAGG IEICITFPTE YVKTQLQLDE
KANPPRYRGI WDCVKQTVDG HGVKGLYRGL SSLLYGSIPK SAVRFGMFEF LSNQMRDANG
KLDSKSSLLC GLGAGVAEAI VVVCPMETIK VKFIHDQCSS NPKYRGFFHG VREIIRDQGI
KGTYQGLTAT VLKQGSNQAI RFFVMTSLRN WYRGDNPNKP MNPLVTGAFG AIAGAASVFG
NTPLDVIKTR MQGLEAHKYK STWDCAYKIL KYEGPKAFYK GTVPRLGRVC LDVAIVFIIY
DEVVKVLNKV WKTD
//
