ID A5EGJ5_BRASB Unreviewed; 431 AA.
AC A5EGJ5;
DT 12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 12-JUN-2007, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=O-acetylhomoserine sulfhydrolase {ECO:0000313|EMBL:ABQ35289.1};
DE EC=2.5.1.49 {ECO:0000313|EMBL:ABQ35289.1};
GN Name=metC {ECO:0000313|EMBL:ABQ35289.1};
GN OrderedLocusNames=BBta_3176 {ECO:0000313|EMBL:ABQ35289.1};
OS Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Bradyrhizobium.
OX NCBI_TaxID=288000 {ECO:0000313|EMBL:ABQ35289.1, ECO:0000313|Proteomes:UP000000246};
RN [1] {ECO:0000313|EMBL:ABQ35289.1, ECO:0000313|Proteomes:UP000000246}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTAi1 / ATCC BAA-1182 {ECO:0000313|Proteomes:UP000000246};
RX PubMed=17540897; DOI=10.1126/science.1139548;
RA Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.C.,
RA Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L.,
RA Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z.,
RA Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.S., Saunders E.,
RA Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G.,
RA Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
RT "Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
RL Science 316:1307-1312(2007).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR EMBL; CP000494; ABQ35289.1; -; Genomic_DNA.
DR RefSeq; WP_012043307.1; NC_009485.1.
DR AlphaFoldDB; A5EGJ5; -.
DR STRING; 288000.BBta_3176; -.
DR KEGG; bbt:BBta_3176; -.
DR eggNOG; COG2873; Bacteria.
DR HOGENOM; CLU_018986_4_0_5; -.
DR OrthoDB; 7316598at2; -.
DR Proteomes; UP000000246; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ABQ35289.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Transferase {ECO:0000313|EMBL:ABQ35289.1}.
FT MOD_RES 210
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 431 AA; 45547 MW; 56593D32ACF43DA8 CRC64;
MPPPKPPAFE TLSLHAGQQP DPATGARAVP IYQTTSYVFD DTEHAAALFN LERAGHIYTR
ISNPTTAVLE ERLAALEGGV GAICTASGQA ALHLAIATLL NAGDHIVASS SLYGGTINLL
AHTLPRFGIT TSFVKPRDLD GFRAAIQPKT KLVIGETLGN PGLEVLDIPR ISAIAHEAGI
PLLIDNTFAT PYLSQPIAQG ADIVMHSATK WLGGHGIAIG GAIIDGGRFD WRASGKFPQL
TEPYAGYHGI VFDEQFGPAA FIMRARTEGL RDFGACLSPT NAFHLLQGVE TLHLRMERHV
ANTSAVLAAL TANKAVDWVL HPSLETHPDH ALAKQLLPRG AGSIISFGIK GGRPAGRKFI
ESLKLISHLA NVGDAKTLVI HPASTTHQQM DAAQLAAAGI GEELIRLSVG IEAVSDIIDD
LGQALRASQK V
//
