UniProt: A5GFN1

Database: UniProt
Entry: A5GFN1_PIG

LinkDB:  A5GFN1_PIG 
Original site:  A5GFN1_PIG

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Ontology (2)   
   GO (2)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (10)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (2)   
   SMART (1)   
All databases (20)   

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ID   A5GFN1_PIG              Unreviewed;       365 AA.
AC   A5GFN1;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   27-MAR-2024, entry version 129.
DE   SubName: Full=Bone morphogenetic protein 7 (Osteogenic protein 1) {ECO:0000313|EMBL:CAN13247.1};
DE   SubName: Full=Bone morphotic protein 7 {ECO:0000313|Ensembl:ENSSSCP00000029077.1};
GN   Name=BMP7 {ECO:0000313|EMBL:CAN13247.1,
GN   ECO:0000313|Ensembl:ENSSSCP00000029077.1,
GN   ECO:0000313|VGNC:VGNC:95491};
GN   ORFNames=CH242-235B3.1-002 {ECO:0000313|EMBL:CAN13247.1};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|EMBL:CAN13247.1};
RN   [1] {ECO:0000313|EMBL:CAN13190.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Kerry G.;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CAN13247.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Phillimore B.;
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSSSCP00000029077.1, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000029077.1,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSSSCP00000029077.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   EMBL; CR974467; CAN13190.1; -; Genomic_DNA.
DR   EMBL; CR956362; CAN13190.1; JOINED; Genomic_DNA.
DR   EMBL; CR956362; CAN13247.1; -; Genomic_DNA.
DR   EMBL; CR974467; CAN13247.1; JOINED; Genomic_DNA.
DR   RefSeq; NP_001098760.1; NM_001105290.1.
DR   PaxDb; 9823-ENSSSCP00000029077; -.
DR   Ensembl; ENSSSCT00000033617.3; ENSSSCP00000029077.1; ENSSSCG00000007501.6.
DR   GeneID; 492315; -.
DR   KEGG; ssc:492315; -.
DR   CTD; 655; -.
DR   VGNC; VGNC:95491; BMP7.
DR   eggNOG; KOG3900; Eukaryota.
DR   GeneTree; ENSGT00940000156490; -.
DR   HOGENOM; CLU_020515_4_1_1; -.
DR   OrthoDB; 2912454at2759; -.
DR   TreeFam; TF316134; -.
DR   Proteomes; UP000008227; Chromosome 17.
DR   Bgee; ENSSSCG00000007501; Expressed in forelimb bud and 26 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd19397; TGF_beta_BMP7; 1.
DR   Gene3D; 2.60.120.970; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF135; BONE MORPHOGENETIC PROTEIN 7; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   PRINTS; PR00669; INHIBINA.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..365
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015086485"
FT   DOMAIN          240..365
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
SQ   SEQUENCE   365 AA;  42006 MW;  A45684ABA06F4134 CRC64;
     MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS
     ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEEGGGPDG QGFSYPYKAV FSTQGPPLAS
     LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY
     IREHFNNETF RISVYQVLQE HLGRDSDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR
     HNLGLQLSVE TLDENSSSDQ RQACKKHELY VSFRDLGWQD WIIAPEGYAA YYCEGECAFP
     LNSYMNATNH AIVQTLVHFI NPETVPKPCC APTQLNAISV LYFDDSSNVI LKKYRNMVVR
     ACGCH
//

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