ID A5JHX6_HBV Unreviewed; 394 AA.
AC A5JHX6;
DT 26-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2007, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:ABQ43893.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:ABQ43893.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:ABQ43893.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HBVAC20 {ECO:0000313|EMBL:ABQ43893.1};
RX PubMed=17451771; DOI=10.1016/j.virol.2007.03.015;
RA De Maddalena C., Giambelli C., Tanzi E., Colzani D., Schiavini M.,
RA Milazzo L., Bernini F., Ebranati E., Cargnel A., Bruno R., Galli M.,
RA Zehender G.;
RT "High level of genetic heterogeneity in S and P genes of genotype D
RT hepatitis B virus.";
RL Virology 365:113-124(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EF514270; ABQ43893.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 117..360
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABQ43893.1"
FT NON_TER 394
FT /evidence="ECO:0000313|EMBL:ABQ43893.1"
SQ SEQUENCE 394 AA; 44209 MW; AE25C01D16EAB9BA CRC64;
GSIRARAHPS TRRYFGVEPS GSGHIDHSVN NSSSCLHQSA VRKAAYSHLS TSKRQSSSGH
AVELHCLPPN SAGSQSQGSV FSCWWLQFRN SKPCSEYCLS HLVNLREDWG PCDEHGEHHI
RIPRTPARVT GGVFLVDKNP HNTAESRLVV DFSQFSRGVT RVSWPKFAVP NLQSLTNLLS
SNLSWLSLDV SAAFYHIPLH PAAMPHLLIG SSGLSRYVAR LSSNSRINNN QYGTMQNLHD
SCSRQLYVSL MLLYKTYGWK LHLYSHPIVL GFRKIPMGVG LSPFLMAQFT SAICSVVRRA
FPHCLAFSYM DDVVLGAKSV QHRESLYTAV TNFLLSLGIH LNPNKTKRWG YSLNFMGYII
GSWGTLPQDH IVQKIKHCFR KLPVNRPIDW KVCQ
//
