ID A5JJ42_SPOEX Unreviewed; 499 AA.
AC A5JJ42;
DT 26-JUN-2007, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2007, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE SubName: Full=GABA-gated chloride channel a2 subunit {ECO:0000313|EMBL:ABQ45398.1};
OS Spodoptera exigua (Beet armyworm) (Noctua fulgens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Amphipyrinae; Spodoptera.
OX NCBI_TaxID=7107 {ECO:0000313|EMBL:ABQ45398.1};
RN [1] {ECO:0000313|EMBL:ABQ45398.1}
RP NUCLEOTIDE SEQUENCE.
RA Shang Q., Gao X., Liang P.;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABQ45398.1}
RP NUCLEOTIDE SEQUENCE.
RA Shang Q.L., Liang P., Gao X.W.;
RT "Cloning, developmental and tissue-specific expression of gamma-
RT aminobutyric acid (GABA) receptor alpha2 subunit gene in Spodoptera exigua
RT (Hubner).";
RL Pestic. Biochem. Physiol. 93:1-7(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
CC {ECO:0000256|ARBA:ARBA00010180}.
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DR EMBL; EF535530; ABQ45398.1; -; mRNA.
DR AlphaFoldDB; A5JJ42; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProt.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
DR CDD; cd19008; LGIC_ECD_GABAR_RDL-like; 1.
DR CDD; cd19049; LGIC_TM_anion; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR002289; GABAAb_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945:SF856; GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT BETA; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR01160; GABAARBETA.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..499
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002684014"
FT TRANSMEM 251..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..245
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 258..478
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT REGION 357..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..383
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 499 AA; 55469 MW; C97AA773CE91671A CRC64;
MHTCRPRGVH SIALVLALAI AWLPHADHAA GAGGGGMFGD VNISAILDSL SVSYDKRVRP
NYGGPPVDVG ATMHVLSISS LSEVKMDFTL DFYFRQFWTD PRLAYKKRTG VETLSVGSEF
IRNIWVPDTF FVNEKQSYFH IATTSNEFIR IHHSGSITRS IRLTITASCP MDPQYFPMDR
QLCNIEIESF GYTMRDIRYK WNEGPNSVGV PSEVSLPQFK VLGHRQRAME ISLTTGNYSR
LACEIQFVRS MGYYLIQIYI PSGLIVIISW VSFWLNRNAT PARVSLGVTT VLTMTTLMSS
TNAALPKISY VKSIDVYLGT CFVMVFASLL EYATVGYMAK RIQMRKQRFT AVQKMAAEKK
MQIDGPPGTS EPLPPPRTST LTRPPPPSRS SEVRFKVHDP KAYSKGGTLE NTINGSRGPA
PAPVPAAPQP DEEAGPPPHL IHASKGINKL LGTTPSDIDK YSRIVFPVCF VCFNLMYWII
YLHVSDVVAD DLVLLGEEN
//
