ID A5K1M2_PLAVS Unreviewed; 920 AA.
AC A5K1M2;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 24-JAN-2024, entry version 93.
DE SubName: Full=Elongation factor G, putative {ECO:0000313|EMBL:EDL46322.1};
GN ORFNames=PVX_113285 {ECO:0000313|EMBL:EDL46322.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL46322.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL46322.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL46322.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL46322.1}.
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DR EMBL; AAKM01000003; EDL46322.1; -; Genomic_DNA.
DR RefSeq; XP_001616049.1; XM_001615999.1.
DR AlphaFoldDB; A5K1M2; -.
DR STRING; 126793.A5K1M2; -.
DR EnsemblProtists; EDL46322; EDL46322; PVX_113285.
DR GeneID; 5475348; -.
DR KEGG; pvx:PVX_113285; -.
DR VEuPathDB; PlasmoDB:PVX_113285; -.
DR InParanoid; A5K1M2; -.
DR OMA; MDDMVGG; -.
DR PhylomeDB; A5K1M2; -.
DR Proteomes; UP000008333; Chromosome 11.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01886; EF-G; 1.
DR CDD; cd03713; EFG_mtEFG_C; 1.
DR CDD; cd04088; EFG_mtEFG_II; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR035649; EFG_V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 2.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:EDL46322.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..920
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002684118"
FT DOMAIN 97..376
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 400..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..735
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 920 AA; 103924 MW; 33BEF1DD274E1F43 CRC64;
MFKLFLRKGH DALAVLVLLS LFVKGSSDAV VSALSRFRRR DGGATHRWCK PVQQSFLTSG
GHTRKSIFRT SSRKQNKVKT FRLMGSNVFA NKNVELENYR NIGIIAHIDA GKTTTTERIL
YYTNVIKKIG EVHEGMSTMD YLDIEREKGI TINAAVTTCY WNGSEKNLGD YRINIIDTPG
HVDFTAEVEK SLRVLDGGVV VFDSSEGVES QSETVWKQAN RYNISRIIFL NKLDKVGANF
ESCIEEIKRK LNKKILILFV PVFEMTNFVS TIDILREQMI VYKNAHEFVY ENIPKSHYDT
FLKYKNMLFE QIAEKFNSFL DVYLSDKPIK VEEVEQYIRK LVVEEKYNVV MCGSALKNKN
VHMLLDSVVK YLPSPIDSIQ NYKKQVIFKH DVNKRGEKIS PLQLPTAGGK QQFGAATREG
GTPGGEVTPG GGAAPSGGAT SDKGTHLQVT SCSVAKPNDQ MSEELNHLNI KNFKRKVVAL
IYKIMNDQHL GNINYVRIYE GQINRGDYLY NNRTKRSEKI SKIFFIHSSE KYELENARAG
DIVGLVGLKD TQIGDTLSST FLRAELKKIK EIPPIISFYI YNKNKNEYEK LINALMKIKK
EDHSFFYHIN PDTKDLLISG VGELHLQIII NKIEKDFNIP IIYGQPQISY KETFVENVEA
RGKYIKQSGG RGQYGDVHIK IEPMYSYQEE EGEEADEGGG SGESGESGES GNGERHNDEQ
NSKQAEDRSG EQDADRNSMN IDTSEVNNNI IIKNEITCGA IPSAYFDAIY TGIREQCNLG
VLSNSPLINI IVRIVDGSFH PVDSNEHAFK LAAGIAIREA ARKTSVRLLE PMMNLNVSVP
TEYLGDVISD LVKKRGKIQH IDESDEYTKE IVARAPMASI LSYVSDLRKI TKGRGNYTMT
LHKYALVPQY IQEQILQKKE
//
