ID A5KEA4_PLAVS Unreviewed; 1041 AA.
AC A5KEA4;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 24-JAN-2024, entry version 96.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPD {ECO:0000256|ARBA:ARBA00014344};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=PVX_087010 {ECO:0000313|EMBL:EDL42322.1};
OS Plasmodium vivax (strain Salvador I).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=126793 {ECO:0000313|EMBL:EDL42322.1, ECO:0000313|Proteomes:UP000008333};
RN [1] {ECO:0000313|EMBL:EDL42322.1, ECO:0000313|Proteomes:UP000008333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Salvador I {ECO:0000313|EMBL:EDL42322.1,
RC ECO:0000313|Proteomes:UP000008333};
RX PubMed=18843361; DOI=10.1038/nature07327;
RA Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E.,
RA Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.,
RA Crabb B.S., Del Portillo H.A., Essien K., Feldblyum T.V.,
RA Fernandez-Becerra C., Gilson P.R., Gueye A.H., Guo X., Kang'a S.,
RA Kooij T.W., Korsinczky M., Meyer E.V., Nene V., Paulsen I., White O.,
RA Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J.,
RA Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J.,
RA Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.;
RT "Comparative genomics of the neglected human malaria parasite Plasmodium
RT vivax.";
RL Nature 455:757-763(2008).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000256|ARBA:ARBA00009146}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDL42322.1}.
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DR EMBL; AAKM01002770; EDL42322.1; -; Genomic_DNA.
DR RefSeq; XP_001608346.1; XM_001608296.1.
DR AlphaFoldDB; A5KEA4; -.
DR STRING; 126793.A5KEA4; -.
DR EnsemblProtists; EDL42322; EDL42322; PVX_087010.
DR GeneID; 5471221; -.
DR KEGG; pvx:PVX_087010; -.
DR VEuPathDB; PlasmoDB:PVX_087010; -.
DR InParanoid; A5KEA4; -.
DR OMA; IREQFFR; -.
DR PhylomeDB; A5KEA4; -.
DR Proteomes; UP000008333; Chromosome 7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 1.10.275.40; -; 2.
DR Gene3D; 1.10.30.20; Bacterial XPD DNA helicase, FeS cluster domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR InterPro; IPR001945; RAD3/XPD.
DR InterPro; IPR042493; XPD_DNA_FeS.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR PANTHER; PTHR11472:SF1; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00852; XRODRMPGMNTD.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EDL42322.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008333}.
FT DOMAIN 8..416
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 106..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1041 AA; 116837 MW; BE64E596DE260DD3 CRC64;
MVVFQLDDLE VFFPYDYIYP EQYAYMRYLK KTLDSEGHCV LEMPTGTGKT VAIFSLITSY
QHGKNDEGKF IFCTRTVAEM EKSLIELKKV IQYRVDTLRR RVVSGEVKGE RADERAEDEM
KDQTGEQTTA NDANDANDAN QANDATTANH ANDATAAQRR SGDLQGDILA IGISARRCMC
VNERVLRKHE REKIDEECRK LTATFVREKK YISQRISKLG STHSDRVSEF IVKNRQHIDV
EDYFDIYHTR NSLEEYNDIG LCGYYENYKK EFLFELIQPG VYTIEDLKVM CKRYKNAQNE
TVPICPYFCA KKVIEVAKVI VLNYQYVIDP KVSKSLFIGR EVNSRVNLHK RDIIVFDEAH
NIDSVCLEAL SVNIDRNVLN KATANIKKLL SKIEASKVLN EEKLREECTR ILRRVREEKR
GGEALGEAMS EAVKEAVGEA ANEAANEAVK EALTEAGSGG GAPGKRRPQE SKGAEVYFDE
DLNLIFPRAA NPSGVDDDAP WGGKQAKGGG LLEGLAKFLG QSVSSLLPGG SGQVAGSSLL
PGGSGQVADS SLFPEGSKDS HGNGSSSSAA AANAATPRED PTELHYSPLL MEDAVKNVVL
PGNIRKSEHF LNLMRIVVMY LRKYVNIYEV TSEGPLSFLY KCERETKLDT SFFKFCFDRL
KALLNALQIV TVDDYSALNV VCNFCTLLGS YFQGFIIICE PYPEATGIYD PVIQFACLDS
SIAMKAVIGK YRSVILTSGT ITPLELYPKL LNFKTVLTAS FPMSFDRNCV CPLIVTNSSD
LVPLSSQFSL RSDLTVIKNY GMLLVEMCKT IPDGIVAYFP SYIYMEEVIS SWYELGIITS
ILECKLIFIE TKDIVSTTIA LHNFKRACDL GKGAVFLSIC RGKIAEGIDF DKHYGKCVIL
FGIPYQYTLS RILKSRLDFL KETYNIQENE FLTFDAMRQA SQCVGRIIRN KKDYGIMIFA
DIRYARNDKK SKLPPWIIKC MELSNVNLTV STAVNISRKF LLNMSQEYKE TGQTKLSQEL
TSDQPRCWAL VKSALNLDDF L
//
