UniProt: A5PEY8

Database: UniProt
Entry: A5PEY8_DANRE

LinkDB:  A5PEY8_DANRE 
Original site:  A5PEY8_DANRE

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Ontology (6)   
   GO (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (8)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (5)   
   ZFIN (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (13)   
   InterPro (7)   
   Pfam (2)   
   PROSITE (3)   
   SMART (1)   
Literature (5)   
   PubMed (5)   
All databases (37)   

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ID   A5PEY8_DANRE            Unreviewed;       607 AA.
AC   A5PEY8; A0A8M1NRT6;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 135.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   Name=pak6b {ECO:0000313|Ensembl:ENSDARP00000090883,
GN   ECO:0000313|RefSeq:NP_001155959.1, ECO:0000313|RefSeq:XP_009293301.1,
GN   ECO:0000313|RefSeq:XP_009293302.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-041014-121};
GN   Synonyms=pak6 {ECO:0000313|RefSeq:NP_001155959.1,
GN   ECO:0000313|RefSeq:XP_009293301.1, ECO:0000313|RefSeq:XP_009293302.1},
GN   si:ch211-158b22.3 {ECO:0000313|RefSeq:XP_009293301.1,
GN   ECO:0000313|RefSeq:XP_009293302.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000090883};
RN   [1] {ECO:0000313|RefSeq:NP_001155959.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001155959.1};
RX   PubMed=23118857; DOI=10.1371/journal.pone.0046642;
RA   Micale L., Loviglio M.N., Manzoni M., Fusco C., Augello B., Migliavacca E.,
RA   Cotugno G., Monti E., Borsani G., Reymond A., Merla G.;
RT   "A fish-specific transposable element shapes the repertoire of p53 target
RT   genes in zebrafish.";
RL   PLoS ONE 7:e46642-e46642(2012).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000113873}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000113873};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|RefSeq:NP_001155959.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001155959.1};
RX   PubMed=23032194;
RA   Law S.H., Sargent T.D.;
RT   "Maternal pak4 expression is required for primitive myelopoiesis in
RT   zebrafish.";
RL   Mech. Dev. 130:181-194(2013).
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000090883, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000090883,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [5] {ECO:0000313|Ensembl:ENSDARP00000090883}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000090883};
RG   Ensembl;
RL   Submitted (MAY-2013) to UniProtKB.
RN   [6] {ECO:0000313|RefSeq:NP_001155959.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001155959.1};
RX   PubMed=26469318;
RA   Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA   Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA   Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA   Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA   Reith W., Hertzano R.;
RT   "RFX transcription factors are essential for hearing in mice.";
RL   Nat. Commun. 6:8549-8549(2015).
RN   [7] {ECO:0000313|RefSeq:NP_001155959.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001155959.1};
RX   PubMed=28252024;
RA   Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA   Choudhary J.S., Emes R.D., Grant S.G.;
RT   "Evolution of complexity in the zebrafish synapse proteome.";
RL   Nat. Commun. 8:14613-14613(2017).
RN   [8] {ECO:0000313|RefSeq:NP_001155959.1, ECO:0000313|RefSeq:XP_009293301.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001155959.1,
RC   ECO:0000313|RefSeq:XP_009293301.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AL772143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001155959.1; NM_001162487.1.
DR   RefSeq; XP_009293301.1; XM_009295026.3.
DR   RefSeq; XP_009293302.1; XM_009295027.3.
DR   STRING; 7955.ENSDARP00000113873; -.
DR   PaxDb; 7955-ENSDARP00000090883; -.
DR   Ensembl; ENSDART00000100110.5; ENSDARP00000090883.3; ENSDARG00000052405.7.
DR   Ensembl; ENSDART00000139794.3; ENSDARP00000113873.1; ENSDARG00000052405.7.
DR   GeneID; 567874; -.
DR   KEGG; dre:567874; -.
DR   AGR; ZFIN:ZDB-GENE-041014-121; -.
DR   CTD; 567874; -.
DR   ZFIN; ZDB-GENE-041014-121; pak6b.
DR   eggNOG; KOG0578; Eukaryota.
DR   HOGENOM; CLU_000288_26_6_1; -.
DR   OMA; QWQSIID; -.
DR   OrthoDB; 460351at2759; -.
DR   TreeFam; TF105352; -.
DR   Reactome; R-DRE-9013148; CDC42 GTPase cycle.
DR   Reactome; R-DRE-9013149; RAC1 GTPase cycle.
DR   Reactome; R-DRE-9013405; RHOD GTPase cycle.
DR   Reactome; R-DRE-9013407; RHOH GTPase cycle.
DR   Reactome; R-DRE-9013424; RHOV GTPase cycle.
DR   Proteomes; UP000000437; Chromosome 20.
DR   Bgee; ENSDARG00000052405; Expressed in zone of skin and 13 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
DR   CDD; cd01093; CRIB_PAK_like; 1.
DR   CDD; cd06659; STKc_PAK6; 1.
DR   Gene3D; 3.90.810.10; CRIB domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR000095; CRIB_dom.
DR   InterPro; IPR036936; CRIB_dom_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR033923; PAK_BD.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR035066; STKc_PAK6.
DR   PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR   PANTHER; PTHR48015:SF19; SERINE_THREONINE-PROTEIN KINASE PAK 6; 1.
DR   Pfam; PF00786; PBD; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00285; PBD; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50108; CRIB; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Kinase {ECO:0000313|RefSeq:NP_001155959.1,
KW   ECO:0000313|RefSeq:XP_009293301.1};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transferase {ECO:0000313|RefSeq:NP_001155959.1,
KW   ECO:0000313|RefSeq:XP_009293301.1}.
FT   DOMAIN          14..27
FT                   /note="CRIB"
FT                   /evidence="ECO:0000259|PROSITE:PS50108"
FT   DOMAIN          333..584
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          95..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          135..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          217..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..162
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..278
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..311
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         362
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   607 AA;  68008 MW;  872FF06DD4D605BB CRC64;
     MFQRRKKKKR KLEISTPKNF QHRVHTSFDP VQGCFIGLPP QWQSLIETLK RPKPVVDPSS
     FTQVQVRPQK SIVRGSFIGH EDYISAAIAQ MSRLSVTSSN SLRRRSPSVR KRAQSLGRLG
     ELAEAETYEY EELNNTNHRN SSDLHRGSRP IQSPQTESRQ SPARARSVHE ATMFTGLMPR
     DILLHRAGCE GTDNAGNKPN QRPVSCLYSQ SDGAKLNSDQ LKMETQRRPQ STYDFKVNSP
     NLPAASKPNG TSSPKPGHGI ISMQTPRRSS TDNTLKLSTI PADVPPAQDS PSEPRQAPSG
     ASSPGLTEPS VTHTQFRAAL QMVVDPGDPR SYLENFIKIG EGSTGVVCIA REKHSGRQVA
     VKMMDLRKQQ RRELLFNEVV IMRDYRHQNV VEMYKSALVG EELWVIMEYL QGGALTNIVS
     ETRLTEEQIA TVCESVLQAL CYLHSQGVIH RDIKSDSILL TLDGRVKLSD FGFCAQISKD
     VPKRRSLVGT PYWMAPEVVS KTPYGTEVDI WSLGIMVVEM VDGEPPYFSE TPISAMKRLR
     DEPPPTARNA SKISPVLRDF LDSMLTREPQ QRSSASDLLQ HPFLLQCSSP RCLIPLVEQT
     RRRTSRC
//

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