ID A5U354_MYCTA Unreviewed; 587 AA.
AC A5U354;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=DNA repair protein RecN {ECO:0000256|ARBA:ARBA00021315, ECO:0000256|PIRNR:PIRNR003128};
DE AltName: Full=Recombination protein N {ECO:0000256|ARBA:ARBA00033408, ECO:0000256|PIRNR:PIRNR003128};
GN Name=recN {ECO:0000313|EMBL:ABQ73454.1};
GN OrderedLocusNames=MRA_1705 {ECO:0000313|EMBL:ABQ73454.1};
OS Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=419947 {ECO:0000313|EMBL:ABQ73454.1, ECO:0000313|Proteomes:UP000001988};
RN [1] {ECO:0000313|EMBL:ABQ73454.1, ECO:0000313|Proteomes:UP000001988}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25177 / H37Ra {ECO:0000313|Proteomes:UP000001988};
RX PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA Wang H., Wang S., Zhao G., Zhang Y.;
RT "Genetic basis of virulence attenuation revealed by comparative genomic
RT analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL PLoS ONE 3:E2375-E2375(2008).
CC -!- FUNCTION: May be involved in recombinational repair of damaged DNA.
CC {ECO:0000256|ARBA:ARBA00003618, ECO:0000256|PIRNR:PIRNR003128}.
CC -!- SIMILARITY: Belongs to the RecN family. {ECO:0000256|ARBA:ARBA00009441,
CC ECO:0000256|PIRNR:PIRNR003128}.
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DR EMBL; CP000611; ABQ73454.1; -; Genomic_DNA.
DR RefSeq; WP_003408385.1; NZ_CP016972.1.
DR AlphaFoldDB; A5U354; -.
DR SMR; A5U354; -.
DR GeneID; 45425665; -.
DR KEGG; mra:MRA_1705; -.
DR eggNOG; COG0497; Bacteria.
DR HOGENOM; CLU_018297_3_0_11; -.
DR Proteomes; UP000001988; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd03241; ABC_RecN; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR004604; DNA_recomb/repair_RecN.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR NCBIfam; TIGR00634; recN; 1.
DR PANTHER; PTHR11059; DNA REPAIR PROTEIN RECN; 1.
DR PANTHER; PTHR11059:SF0; DNA REPAIR PROTEIN RECN; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF003128; RecN; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|PIRNR:PIRNR003128};
KW DNA repair {ECO:0000256|PIRNR:PIRNR003128};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001988}.
FT DOMAIN 2..535
FT /note="RecF/RecN/SMC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02463"
SQ SEQUENCE 587 AA; 62229 MW; 4B7051EFB60102E7 CRC64;
MLTELRIESL GAISVATAEF DRGFTVLTGE TGTGKTMVVT GLHLLGGARA DATRVRSGAD
RAVVEGRFTT TDLDDATVAG LQAVLDSSGA ERDEDGSVIA LRSISRDGPS RAYLGGRGVP
AKSLSGFTNE LLTLHGQNDQ LRLMRPDEQR GALDRFAAAG EAVQRYRKLR DAWLTARRDL
VDRRNRAREL AQEADRLKFA LNEIDTVDPQ PGEDVALVAD IARLSELDTL REAATTARAT
LCGTPDADAF DRGAVDSLGR ARAALQSSDD AALRGLAEQV GEALTVVVDA VAELGAYLDE
LPADASALDA KLARQAQLRT LTRKYAADID GVLRWADEAR ARLAQLDVSE EGLAALERRT
GELAHELGQA AVDLSTIRRK AAKRLAKEVS AELSALAMAD AEFTIGVTTE LADHGDPVAL
ALASGELARA GADGVDAVEF GFVAHRGMTV LPLAKSASGG ELSRVMLSLE VVLATSRKQA
AGTTMVFDEI DAGVGGWAAV QIGRRLARLA RTHQVIVVTH LPQVAAYADV HLMVQRTGRD
GASGVRRLTS EDRVAELARM LAGLGDSDSG RAHARELLET AQNDELT
//
