ID   A5UF90_HAEIG            Unreviewed;       482 AA.
AC   A5UF90;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=TldD {ECO:0000313|EMBL:ABQ99445.1};
GN   OrderedLocusNames=CGSHiGG_01945 {ECO:0000313|EMBL:ABQ99445.1};
OS   Haemophilus influenzae (strain PittGG).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=374931 {ECO:0000313|EMBL:ABQ99445.1, ECO:0000313|Proteomes:UP000001990};
RN   [1] {ECO:0000313|EMBL:ABQ99445.1, ECO:0000313|Proteomes:UP000001990}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PittGG {ECO:0000313|EMBL:ABQ99445.1,
RC   ECO:0000313|Proteomes:UP000001990};
RX   PubMed=17550610; DOI=10.1186/gb-2007-8-6-r103;
RA   Hogg J.S., Hu F.Z., Janto B., Boissy R., Hayes J., Keefe R., Post J.C.,
RA   Ehrlich G.D.;
RT   "Characterization and modeling of the Haemophilus influenzae core and
RT   supragenomes based on the complete genomic sequences of Rd and 12 clinical
RT   nontypeable strains.";
RL   Genome Biol. 8:R103.1-R103.18(2007).
CC   -!- SIMILARITY: Belongs to the peptidase U62 family.
CC       {ECO:0000256|ARBA:ARBA00005836}.
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DR   EMBL; CP000672; ABQ99445.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5UF90; -.
DR   KEGG; hiq:CGSHiGG_01945; -.
DR   HOGENOM; CLU_026425_1_0_6; -.
DR   Proteomes; UP000001990; Chromosome.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR   InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR   InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR   InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR   InterPro; IPR025502; TldD.
DR   InterPro; IPR035068; TldD/PmbA_N.
DR   InterPro; IPR036059; TldD/PmbA_sf.
DR   PANTHER; PTHR30624:SF4; METALLOPROTEASE TLDD; 1.
DR   PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR   Pfam; PF01523; PmbA_TldD_1st; 1.
DR   Pfam; PF19290; PmbA_TldD_2nd; 1.
DR   Pfam; PF19289; PmbA_TldD_3rd; 1.
DR   PIRSF; PIRSF004919; TldD; 1.
DR   SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670}.
FT   DOMAIN          35..97
FT                   /note="Metalloprotease TldD/E N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01523"
FT   DOMAIN          126..239
FT                   /note="Metalloprotease TldD/E central"
FT                   /evidence="ECO:0000259|Pfam:PF19290"
FT   DOMAIN          247..480
FT                   /note="Metalloprotease TldD/E C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19289"
SQ   SEQUENCE   482 AA;  51689 MW;  F5E0F9888CF9E63B CRC64;
     MLNQVSNTLL TPSNLSTQTL LNIFDIISHR NIDYADLYFQ LSQDESWVLE DGIIKEGGFH
     IDRGVGVRAV SGEKTGFAYA DQINLASLQQ CAEAVKGIAQ VKQGNLISPS AFNVVNPIAR
     YAAINPLESL TKEKKIELLH LVDRTARAED HRVTKVSASL SSVYEEVLIM ATDGTLAADI
     RPLVRLSISV LVEENGKRER GSYGSGGRFG LDWFFEVVDG DIRAVLFAKE AVHQALVNLS
     AVAAPAGLMP VVLGAGWPGV LLHEAVGHGL EGDFNRKESS LFTGKIGEQV TSPLCTIVDD
     GTIENRRGSL TIDDEGVPSQ CNVLIKDGIL QGYMQDKMNA RLMGVAPTGN GRRESYAHLP
     MPRMTNTYML AGQSQFDDLI ASVEQGIYAP HFGGGQVDIT SGKFVFSTSE AYLIEKGKIT
     KPVKGATLIG SGIEVMQKIS MVADKSELDL GIGVCGKEGQ SVPVGVGQPA LKIDEITVGG
     TN
//