ID   A5USA2_ROSS1            Unreviewed;      1748 AA.
AC   A5USA2;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=Large extracellular alpha-helical protein-like protein {ECO:0000313|EMBL:ABQ89505.1};
GN   OrderedLocusNames=RoseRS_1097 {ECO:0000313|EMBL:ABQ89505.1};
OS   Roseiflexus sp. (strain RS-1).
OC   Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Roseiflexineae;
OC   Roseiflexaceae; Roseiflexus.
OX   NCBI_TaxID=357808 {ECO:0000313|EMBL:ABQ89505.1, ECO:0000313|Proteomes:UP000006554};
RN   [1] {ECO:0000313|Proteomes:UP000006554}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS-1 {ECO:0000313|Proteomes:UP000006554};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chertkov O., Brettin T., Bruce D., Han C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Mikhailova N., Bryant D.A., Richardson P.;
RT   "Complete sequence of Roseiflexus sp. RS-1.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
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DR   EMBL; CP000686; ABQ89505.1; -; Genomic_DNA.
DR   RefSeq; WP_011955858.1; NC_009523.1.
DR   STRING; 357808.RoseRS_1097; -.
DR   KEGG; rrs:RoseRS_1097; -.
DR   eggNOG; COG2373; Bacteria.
DR   HOGENOM; CLU_240655_0_0_0; -.
DR   OrthoDB; 9767116at2; -.
DR   Proteomes; UP000006554; Chromosome.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 2.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   Gene3D; 2.60.40.3710; -; 3.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR032812; SbsA_Ig.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF13205; Big_5; 4.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          1125..1212
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
SQ   SEQUENCE   1748 AA;  186533 MW;  066E4A40FB40FB76 CRC64;
     MRFLRQVGLI WTAALLVVVL ASLALPGARF LLLPWLSDSP VVVAVSPPDG ARDVSPRTAL
     IIQFNTPMNP PGVERALRIE PESDVVYAWD DSRTTLTVTP TKTLQAGMRY RVSIDETALS
     RFFRPLEEPF VFTFETAPPP AVTSLWPRDG SVEVPVDTLI SVRFSRSIVP PDRLAVPELS
     PAFRTDPPVS GSVVWIDPAT LLFRPDQPLR PGVRYTCSLS PDLTDQSGTP LGRAYSWSFT
     TLAPTVLSVS PPPNARQVAL REPLRIVFSQ PVDRQALEAA LSVTPPMPGA LEDAVLPDGT
     QVVTYTPTAE WQAGVVYTIA LPEKTADGSP LLVKPYRWSF MTAPKPALIG RFPGEGQLLP
     PGGSVRLIFS TPIDAGALRD NLRVEPPVAH LRVVTNDGEA RIDAQLQAAT LYTITIPASL
     SDRAGVALER DYQVRFFTAP AAPSLTLPEA NGRVIRSLPD RAIDLLTRRT NLSELRLTLY
     PLDEATLLRA LSFSDAEWTS FEPARYGLSP LRFWTQPLTD PLNTVVEERV TVTLDGGAPL
     PPGFYFLRIR SPERAGAGVL LAVSRVTLSF QVVGQRAIVW VTDIASTSVI SDTPLALYRQ
     GTLIAVGRSD ERGVWETDLS GVNPRDLVAV ATLLPAFATP EAPVQSAPAP RLRVILATDR
     SIYSPGESVA IRGFIRQEGS QAFEIPDPGQ SLDLDIQGPS GVRLRKRIVL DASGMIDATL
     ALPANAPSGV YRLFTPRDER AALQFYVHPP SSPLRASITR ITQDQVVVSV RTPEDLPIAG
     ATITWTIDPE PILLPVRDDF VFSRPETPLA SLSGVGVTNE QGMLTLALPS DWYHVRIQAQ
     IVEAGGLAAT LDRTIYTAPA PAVGLRAATS LVGAGGQTSV EVVTLAGDQP LAAQRVQIDA
     VRLNGETASD MGVSPSEWQL LSRVITTDND GRATFAVSLP EPGVYRVRAA LVGGGLASPP
     TDIVLRAYQP GFTAWSEPRT SVSLVADRAR YQPGDTALLL PLAPIPEGLA LLTVQRASGD
     VVTELRTVRA GEPLTLTLTP ADAPVVRVTL TSGVQSPAYR RLQVDVPVTA ITPSLLATVT
     TDAQTYDPGA TAALTITVTD ARGAPVSADV LVRITAGDDD RQEPVVWRTG RTDRNGVIRF
     DAPLPQTPGT HEVRVWVAGE RGFGVTGAAL QARQPIVGQI VAPQFARAGD RFVVGVRLTT
     QEDVPRQTRI TMRMPDGTAV VQTTAVPTEG AALATFTVQA PSSGAAMAVQ AIVEADDAFS
     ETLRTDLSVL PPATTVLSTG SALVTDRFEA AIPAPQARWG SLDIAVAPSL DALALEQARA
     LAALADRHAL DNVAIILMAA SLADARQETQ IAVDHLAKLQ AADGGWTWKR QGSSSPVVTA
     ATLEVLARAK ESGFAVPDTT LERAINLASR LANDPVLSLE TRICLSYALT QLDAPVPREW
     DENALNASGL ACRLLMLPPD QARIDPALPR LISLAQRTQT EAWWTAPDGG AFPHDDVATT
     AIAARAVHHA SPRHPLTANA ARWLISRMTP AGWGDAYTTA RVVQALRAIA PASTPATVAM
     TLNGAPVVAP AAPDAVLRIV PIPLSDLRPV NTLVVTGDGN PALVAWQVTS ADHAALPAEG
     VGLIREFLDP QTGVLLDPAR LRVGQLIKVR LTCVAHTERH FVTLRDAFPA GFVPVDAGSS
     PVFRQIDLFS DRIELAVEAL APGIYQYTYL VRAVTPGSYA VPPPELILPG ARALTGTATT
     TVVQIVAP
//