ID A5YI04_STREE Unreviewed; 732 AA.
AC A5YI04;
DT 10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Penicillin-binding protein 2x {ECO:0000313|EMBL:ABR03857.1};
DE Flags: Fragment;
GN Name=pbp2x {ECO:0000313|EMBL:ABR03857.1};
OS Streptococcus pneumoniae.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1313 {ECO:0000313|EMBL:ABR03857.1};
RN [1] {ECO:0000313|EMBL:ABR03857.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=0.10FR96 {ECO:0000313|EMBL:ABR03857.1}, 0.56SW00
RC {ECO:0000313|EMBL:ABR03879.1}, and 595.6SP00
RC {ECO:0000313|EMBL:ABR04008.1};
RX PubMed=17475572; DOI=10.1016/j.meegid.2007.03.004;
RA Stanhope M.J., Walsh S.L., Becker J.A., Miller L.A., Lefebure T., Lang P.,
RA Bitar P.D., Amrine-Madsen H.;
RT "The relative frequency of intraspecific lateral gene transfer of
RT penicillin binding proteins 1a, 2b, and 2x, in amoxicillin resistant
RT Streptococcus pneumoniae.";
RL Infect. Genet. Evol. 7:520-534(2007).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; EF501483; ABR03857.1; -; Genomic_DNA.
DR EMBL; EF501505; ABR03879.1; -; Genomic_DNA.
DR EMBL; EF501634; ABR04008.1; -; Genomic_DNA.
DR AlphaFoldDB; A5YI04; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR CDD; cd06573; PASTA; 2.
DR Gene3D; 2.20.70.70; -; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 2.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 2.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005543; PASTA_dom.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR NCBIfam; NF038271; strep_PBP2X; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR Pfam; PF03793; PASTA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SMART; SM00740; PASTA; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
DR SUPFAM; SSF54184; Penicillin-binding protein 2x (pbp-2x), c-terminal domain; 2.
DR PROSITE; PS51178; PASTA; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 614..673
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT DOMAIN 674..732
FT /note="PASTA"
FT /evidence="ECO:0000259|PROSITE:PS51178"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABR03857.1"
SQ SEQUENCE 732 AA; 80097 MW; B4B21E32B16396A0 CRC64;
AENRRRVGKS LSLLSVFVFA IFLVNFAVII GTGTRFGTDL AKEAKKVHQT TRTVPAKRGT
IYDRNGVPIA EDATSYNVYA VIDENYKSAT GKILYVEKTQ FNKVAEVFHK YLDMEESYVR
EQLSQPNLKQ VSFGAKGNGI TYANMMSIKK ELEAAEVKGI DFTTSPNRSY PNGQFASSFI
GLAQLHENED GSKSLLGTSG MESSLNSILA GTDGIITYEK DRLGNIVPGT EQVSQRTMDG
KDVYTTISSP LQSFMETQMD AFQEKVKGKY MTATLVSAKT GEILATTQRP TFDADTKEGI
TEDFVWRDIL YQSNYEPGST MKVMMLAAAI DNNTFPGGEV FNSSELKIAD ATIRDWDVNE
GLTGGRMMTF SQGFAHSSNV GMTLLEQKMG DATWLDYLNR FKFGVPTRFG LTDEYAGQLP
ADNIVNIAQS SFGQGISVTQ TQMIRAFTAI ANDGVMLEPK FISAIYDPND QTARKSQKEI
VGNPVSKDAA SLTRTNMVLV GTDPVYGTMY NHSTGKPTVT VPGQNVALKS GTAQIADEKN
GGYLVGLTDY IFSAVSMSPA ENPDFILYVT VQQPEHYSGI QLGEFANPIL ERASAMKDSL
NLQTTAKALE QVSQQSPYPM PSVKDISPGD LAEELRRNLV QPIVVGTGTK IKNSSAEEGK
NLAPNQQVLI LSDKAEEVPD MYGWTKETAE TLAKWLNIEL EFQGSGSTVQ KQDVRANTAI
KDIKKITLTL GD
//