ID   A5ZYC2_9FIRM            Unreviewed;       749 AA.
AC   A5ZYC2;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   SubName: Full=DNA internalization competence protein ComEC/Rec2-like protein {ECO:0000313|EMBL:EDM85399.1};
GN   ORFNames=RUMOBE_04031 {ECO:0000313|EMBL:EDM85399.1};
OS   Blautia obeum ATCC 29174.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia.
OX   NCBI_TaxID=411459 {ECO:0000313|EMBL:EDM85399.1, ECO:0000313|Proteomes:UP000006002};
RN   [1] {ECO:0000313|EMBL:EDM85399.1, ECO:0000313|Proteomes:UP000006002}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29174 {ECO:0000313|EMBL:EDM85399.1,
RC   ECO:0000313|Proteomes:UP000006002};
RA   Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA   Thiruvilangam P., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EDM85399.1, ECO:0000313|Proteomes:UP000006002}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29174 {ECO:0000313|EMBL:EDM85399.1,
RC   ECO:0000313|Proteomes:UP000006002};
RA   Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA   Gordon J.;
RT   "Draft genome sequence of Ruminococcus obeum (ATCC 29174).";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDM85399.1}.
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DR   EMBL; AAVO02000033; EDM85399.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5ZYC2; -.
DR   eggNOG; COG0658; Bacteria.
DR   eggNOG; COG2333; Bacteria.
DR   HOGENOM; CLU_010363_2_2_9; -.
DR   Proteomes; UP000006002; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR025405; DUF4131.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF13567; DUF4131; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        176..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        231..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        255..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        279..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        313..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        351..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        387..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        464..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          497..701
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   749 AA;  81407 MW;  2887E4658F4C200B CRC64;
     MDLAGFARIS GNPLPESVQL YIEKHPEAVI CGEVQQYQAT EYSLSAYLKH VCLIVGSEQI
     PIKNLRVFLK SNKEFPIGTT VKISGKLEEI PEPRNPGEFD SRQFYACQKI YYFMKNGAVL
     AWSSKYSRYG QFMQNLKSKI MQTLDIAAKE DAGIFEAMLL GEKDNLEDEV KIRYQMAGII
     HILAISGLHI SVLGIGFFDL LKRAGFGNVS AGMVVLSVLL QYGILTGESV SAMRAVGMFL
     VAVGARIAGR TYDLLTALAV SAVLLLLDAP ANLYNSGFWL SFGAVAGLGV VAPVLAGCIR
     VENRLAASVM KTLVSSIAVQ MTTFPIMLRI YGEISLAGFF LNLLVLPTVS VVLVSGIAAV
     AVGMASVSAA VYVVLPGRVL LFLYEKLCEL AAGIPFCTWI AGSPKLWQCA GYYVLLFLGV
     EILGMSRGTV TWNGATGKRA GNHAFMQEEK NHGEGKGWLR KYQLLSGISG IMLILGLGIL
     IYHPSGNLQI TCLDIGQGDC ISIQLPQGQN FLIDGGSSNK KNIAHYQILP FLKNRGIGVI
     DAILISHTDN DHISGVLELF DYMRTHLTSV RVKNLILPEW TQPDDAYQQL VDKAQAAGVN
     VQKGRKGEQI ALGKASLRFL SPDRGTAGTD ANEDGMVVEL TYGGFEGLFT GDIGTETEKK
     LLPELEDVDF LKVGHHGSRY STCQEFLDVV RPELAVVSCS ATNTYGHPSG ETIERLEDSG
     AKIWYTMKEG AVTAETDGKE VWVDTFVHP
//