ID A6BF51_9FIRM Unreviewed; 608 AA.
AC A6BF51;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:EDM63638.1};
GN ORFNames=DORLON_00921 {ECO:0000313|EMBL:EDM63638.1};
OS Dorea longicatena DSM 13814.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Dorea.
OX NCBI_TaxID=411462 {ECO:0000313|EMBL:EDM63638.1, ECO:0000313|Proteomes:UP000004016};
RN [1] {ECO:0000313|EMBL:EDM63638.1, ECO:0000313|Proteomes:UP000004016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13814 {ECO:0000313|EMBL:EDM63638.1,
RC ECO:0000313|Proteomes:UP000004016};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Thiruvilangam P., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDM63638.1, ECO:0000313|Proteomes:UP000004016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13814 {ECO:0000313|EMBL:EDM63638.1,
RC ECO:0000313|Proteomes:UP000004016};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Dorea longicatena (DSM 13814).";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDM63638.1}.
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DR EMBL; AAXB02000003; EDM63638.1; -; Genomic_DNA.
DR AlphaFoldDB; A6BF51; -.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_021572_1_0_9; -.
DR Proteomes; UP000004016; Unassembled WGS sequence.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR025288; DUF4080.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR PANTHER; PTHR43409:SF18; RADICAL SAM SUPERFAMILY PROTEIN; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF13311; DUF4080; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
DR PROSITE; PS50142; RNASE_3_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 14..145
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 208..438
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
FT DOMAIN 491..546
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
SQ SEQUENCE 608 AA; 72439 MW; 1C6D95CB18EC1D19 CRC64;
MPEGKNSDLE ERIMKILLAA VNAKYIHSNL AVYSLKAYAE DPAVEIGEYT INQQKDDILM
DIYKRQPDIL CLSCYIWNLD YIEEIVLEIG KLRPDMPIWL GGPEVSYDAK EVLRRLPCVK
GVMKGEGEKT FKEICRIYRN EFEKRENVCG YQDKNVDNSW KKSESVDNQL KGVDGITFRE
EKEKIIDNPW RPIMDLSEVP FVYDHMEDFE HKIIYYETSR GCPFSCSYCL SSVDKRLRFR
DIELVKKELQ FFLDHKVPQV KFVDRTFNCK HDHSIAIWKY IMEHDNGITN FHFEIAADIL
NEEELELLEQ MRPGLVQLEI GVQSTNPKTI KEIHRVMDFE KVSKIVRRIQ NKVNVHEHLD
LIAGLPYEDV ESFAHSFDDV YALKPEQLQL GFLKVLKGSF MQEHQEEYGI VHKAHPPYEV
LYTKWISYED VLRLKGIEEM VEVYYNSRQF TNTMEELEKE YDSAFTMYDR LASYYEDNGY
NAVQHKRSAR YEILLNYIRL HHKEKEDLFR EVLTYDYYLR ENAKSRPEFA GDYLVEKNVA
RAFYEKEEET HMYLPDYGKY DRNQMRKMTH LEYFKLADTY ILFDYQNRNP LNQEARVCKV
EIDKVRIK
//
