ID A6EP23_9BACT Unreviewed; 698 AA.
AC A6EP23;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Putative transmembrane protein {ECO:0000313|EMBL:EDM44612.1};
GN ORFNames=SCB49_13610 {ECO:0000313|EMBL:EDM44612.1};
OS unidentified eubacterium SCB49.
OC Bacteria; Bacteroidota; environmental samples.
OX NCBI_TaxID=50743 {ECO:0000313|EMBL:EDM44612.1, ECO:0000313|Proteomes:UP000003659};
RN [1] {ECO:0000313|EMBL:EDM44612.1, ECO:0000313|Proteomes:UP000003659}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCB49 {ECO:0000313|EMBL:EDM44612.1,
RC ECO:0000313|Proteomes:UP000003659};
RA Hagstrom A., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDM44612.1}.
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DR EMBL; ABCO01000003; EDM44612.1; -; Genomic_DNA.
DR AlphaFoldDB; A6EP23; -.
DR STRING; 50743.SCB49_13610; -.
DR Proteomes; UP000003659; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF37; SIGNAL TRANSDUCTION HISTIDINE-PROTEIN KINASE_PHOSPHATASE UHPB; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR Pfam; PF13181; TPR_8; 3.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50005; TPR; 2.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003659};
KW Signal {ECO:0000256|SAM:SignalP};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:EDM44612.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..698
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002695997"
FT TRANSMEM 443..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 189..222
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 230..263
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 510..698
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 698 AA; 80441 MW; 27D4D569EF11A993 CRC64;
MFFKPRYYFC FLLLCYATIG LAQTTTPTIE SEEKKVDELF YYFNNGFEKK AYKEAHHLLG
TFKSDKAITN TNLLLAYYHN KYVAMDSSIY YTQKALKSKK NIEDSLGVRL TILSYQLLAL
NNKNKGLYNE SKKWHIKGAE LSEKHNETNL YYTHLHGLAS TYVTLGKTEE ALALFDKCIK
YSNDEELILG SYINLGSIYS SLSKYEKSNA YLQKAKDICE KDTHRKQALV NVIINIGDNY
LGKGDTDNAL TSYYEAKKIS NDNRSYNLEL IILGKIGNVL YNDKQDHEAL LIFSNTLIKA
INLGNLDIEM NSYLMLEKLS VRKGDYRSAY SYGKHYSKIK DSIENSQAAK EINNLEVKFE
TLEKEKTIKL LKIENLNNTL NIKNKDVEIE KYKLQKAIIA KQNENQVLQL QNGVEKRKNE
IALLKEKEAL KALELDREKT IKYIVLVAFF ILLVPIIGLL IIYYQKLQAQ GLLNLKEKEI
NEQQVISLKK DQELKLIKAA VRGQDQERKK IAQEMHDSVG GNLAAIKLQF SQLSKHPDKL
KLIYSQLDDT YEQVRSISHN LLPKKIRENE FVFLIKEYIQ TVKEASELNI NVSFYDEEKI
NALNKILQNE LFSIFQELTT NTLKYAKANT IDIQLDLLND SLFFVYEDDG VGFDLSMTRL
GIGLTNIKNR IETYNGKLNI DSKHNRGTNI HIEIPLKA
//
