ID A6GZY1_FLAPJ Unreviewed; 392 AA.
AC A6GZY1;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=acetyl-CoA C-acetyltransferase {ECO:0000256|ARBA:ARBA00012705};
DE EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
GN OrderedLocusNames=FP1586 {ECO:0000313|EMBL:CAL43654.1};
OS Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 /
OS JIP02/86).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=402612 {ECO:0000313|EMBL:CAL43654.1, ECO:0000313|Proteomes:UP000006394};
RN [1] {ECO:0000313|EMBL:CAL43654.1, ECO:0000313|Proteomes:UP000006394}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86
RC {ECO:0000313|Proteomes:UP000006394};
RX PubMed=17592475; DOI=10.1038/nbt1313;
RA Duchaud E., Boussaha M., Loux V., Bernardet J.F., Michel C., Kerouault B.,
RA Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.F.,
RA Claverol S., Dumetz F., Le Henaff M., Benmansour A.;
RT "Complete genome sequence of the fish pathogen Flavobacterium
RT psychrophilum.";
RL Nat. Biotechnol. 25:763-769(2007).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; AM398681; CAL43654.1; -; Genomic_DNA.
DR RefSeq; WP_011963699.1; NC_009613.3.
DR RefSeq; YP_001296463.1; NC_009613.3.
DR AlphaFoldDB; A6GZY1; -.
DR STRING; 402612.FP1586; -.
DR EnsemblBacteria; CAL43654; CAL43654; FP1586.
DR GeneID; 66552227; -.
DR KEGG; fps:FP1586; -.
DR PATRIC; fig|402612.5.peg.1598; -.
DR eggNOG; COG0183; Bacteria.
DR HOGENOM; CLU_031026_0_1_10; -.
DR OrthoDB; 9764892at2; -.
DR Proteomes; UP000006394; Chromosome.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919:SF171; ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:CAL43654.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006394};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:CAL43654.1}.
FT DOMAIN 4..259
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 267..388
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 88
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 346
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 376
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 392 AA; 41618 MW; 6C3681157E23078C CRC64;
MNEVYIIAAK RTPIGGFLGN LAEFSATQLG AIAIKEAYQS VGIDPNAICS VYMGNVLSAN
LGQSPARQAS IFAGISENTD CTTVNKVCAA GMKATILGAQ QIQLGLEDLV ITGGMESMSN
VPHYNLLRKP VKFGDANCID GLLNDGLTDV YNNFHMGNAA EMCVEKYNLT REQQDEYALS
SYAKAVKATN EGKFTNEIIP IKINHKTGET IVNNDEDIFK VIPEKVSKLN PVFVKNGTIT
AANASNLNDS AAALLLASKE AVEKYNLKPL AKIISYADAA QAPEWFTTAP SIAITKALKQ
AKLSLNDIDY FEINEAYAAV VLANQKILDL DSKKINIYGG AVAMGHPLGA SGARIICTLI
SVLKQEGGKY GVASICNGGG GASAIIIENI NL
//
