ID A6LD52_PARD8 Unreviewed; 622 AA.
AC A6LD52;
DT 24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:ABR43616.1};
GN OrderedLocusNames=BDI_1881 {ECO:0000313|EMBL:ABR43616.1};
OS Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM
OS 5825 / NCTC 11152).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC Parabacteroides.
OX NCBI_TaxID=435591 {ECO:0000313|EMBL:ABR43616.1, ECO:0000313|Proteomes:UP000000566};
RN [1] {ECO:0000313|EMBL:ABR43616.1, ECO:0000313|Proteomes:UP000000566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152
RC {ECO:0000313|Proteomes:UP000000566};
RX PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA Knight R.D., Gordon J.I.;
RT "Evolution of symbiotic bacteria in the distal human intestine.";
RL PLoS Biol. 5:1574-1586(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; CP000140; ABR43616.1; -; Genomic_DNA.
DR RefSeq; WP_011966623.1; NC_009615.1.
DR AlphaFoldDB; A6LD52; -.
DR STRING; 435591.BDI_1881; -.
DR PaxDb; 435591-BDI_1881; -.
DR KEGG; pdi:BDI_1881; -.
DR PATRIC; fig|435591.13.peg.1864; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_2_10; -.
DR BioCyc; PDIS435591:G1G5A-1934-MONOMER; -.
DR Proteomes; UP000000566; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000566};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 14..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..225
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 263..589
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 622 AA; 70023 MW; B72EA7E6F94EDD7C CRC64;
MENNTKYEFE NRRYVLGGAV ILLVIIFIIR LFILQVVDND YKAWADSNAF LKKTLYPSRG
MMYDRNGKLL VYNQPAYDVM LIMREIQPFD TLDFCDVLGI TKEQFLKRIA DIKNRRLNPG
YSSYVPQVFM NQLSAQEYGV LQEKLYKFPG FYIQNRTIRQ YEYPNAALVL GNIGEVNRKD
IESDSYYTQG DYSGRTGIEQ SYEEYLRGVK GVEILLRDAH GRIKGRYEEG LHDIQPESGK
NLKLSLDMDL QAYGEKLMQN KLGGIVMIEP ETGEVLCMVS APTYDPSILI GRQRGKNYVA
LQKDPLKPLF NRPLMAQYPP GSTFKPTQGL IFLQEGVITP ETQYTCAHGY TFRGGKPACH
GHPSPLNLVG ALATSCNSFF PWGLHDMIDS RKRYPSVQEA FEVWKNHMVS MGYGYKLGID
LPGEKRGFIP NSKFYDKVYR GRWNSSTVIS IAIGQGEILA TPLQICNLAA TVANRGYYIT
PHVVKEIQDT PLDTLYSKRH YTSVDTHYYS YIAEGMRGAV TGTAYGGTCR GAALPDIEVC
GKTGTSENPH GKDHSIFMGF APYQKPKVAI AVFVENAGFG ATYAVPIGKL MLEKYLKGEI
SEANKATEEY IMNAVILPNN AL
//
