ID ASB14_HUMAN Reviewed; 587 AA.
AC A6NK59; C9JX97; Q8WXK2; Q92816;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 27-MAR-2024, entry version 125.
DE RecName: Full=Ankyrin repeat and SOCS box protein 14;
DE Short=ASB-14;
GN Name=ASB14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Kile B.T., Nicola N.A.;
RT "SOCS box proteins.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Adipocyte;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex
CC which mediates the ubiquitination and subsequent proteasomal
CC degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A6NK59-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A6NK59-2; Sequence=VSP_036925, VSP_036926;
CC Name=3;
CC IsoId=A6NK59-3; Sequence=VSP_046197, VSP_046198;
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin-protein ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000305}.
CC -!- CAUTION: Was originally derived from a readthrough transcript including
CC ASB14 and DNAH12. {ECO:0000305}.
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DR EMBL; AF403032; AAL57351.1; -; mRNA.
DR EMBL; AL832472; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC093928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46856.2; -. [A6NK59-3]
DR RefSeq; NP_001136205.2; NM_001142733.2. [A6NK59-3]
DR RefSeq; NP_569058.1; NM_130387.5. [A6NK59-2]
DR RefSeq; XP_016861225.1; XM_017005736.1. [A6NK59-3]
DR RefSeq; XP_016861226.1; XM_017005737.1. [A6NK59-3]
DR AlphaFoldDB; A6NK59; -.
DR SMR; A6NK59; -.
DR BioGRID; 126775; 57.
DR IntAct; A6NK59; 1.
DR STRING; 9606.ENSP00000419199; -.
DR iPTMnet; A6NK59; -.
DR PhosphoSitePlus; A6NK59; -.
DR BioMuta; ASB14; -.
DR MassIVE; A6NK59; -.
DR PaxDb; 9606-ENSP00000419199; -.
DR PeptideAtlas; A6NK59; -.
DR ProteomicsDB; 12092; -.
DR ProteomicsDB; 1380; -. [A6NK59-1]
DR ProteomicsDB; 1381; -. [A6NK59-2]
DR Antibodypedia; 56010; 22 antibodies from 12 providers.
DR DNASU; 142686; -.
DR Ensembl; ENST00000389601.3; ENSP00000374252.3; ENSG00000239388.9. [A6NK59-1]
DR Ensembl; ENST00000487349.6; ENSP00000419199.1; ENSG00000239388.9. [A6NK59-3]
DR GeneID; 142686; -.
DR KEGG; hsa:142686; -.
DR MANE-Select; ENST00000487349.6; ENSP00000419199.1; NM_001142733.3; NP_001136205.2. [A6NK59-3]
DR UCSC; uc062kwt.1; human. [A6NK59-1]
DR AGR; HGNC:19766; -.
DR CTD; 142686; -.
DR DisGeNET; 142686; -.
DR GeneCards; ASB14; -.
DR HGNC; HGNC:19766; ASB14.
DR HPA; ENSG00000239388; Group enriched (skeletal muscle, tongue).
DR neXtProt; NX_A6NK59; -.
DR OpenTargets; ENSG00000239388; -.
DR PharmGKB; PA134983884; -.
DR VEuPathDB; HostDB:ENSG00000239388; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000156550; -.
DR HOGENOM; CLU_023739_1_0_1; -.
DR InParanoid; A6NK59; -.
DR OMA; QGWLPVH; -.
DR OrthoDB; 5479200at2759; -.
DR PhylomeDB; A6NK59; -.
DR TreeFam; TF315127; -.
DR PathwayCommons; A6NK59; -.
DR Reactome; R-HSA-8951664; Neddylation.
DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR SignaLink; A6NK59; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 142686; 10 hits in 1185 CRISPR screens.
DR GenomeRNAi; 142686; -.
DR Pharos; A6NK59; Tdark.
DR PRO; PR:A6NK59; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; A6NK59; Protein.
DR Bgee; ENSG00000239388; Expressed in primordial germ cell in gonad and 98 other cell types or tissues.
DR Genevisible; A6NK59; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03730; SOCS_ASB14; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24161; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24161:SF85; LD20463P-RELATED; 1.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 11.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 7.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Reference proteome; Repeat.
FT CHAIN 1..587
FT /note="Ankyrin repeat and SOCS box protein 14"
FT /id="PRO_0000066951"
FT REPEAT 82..112
FT /note="ANK 1"
FT REPEAT 117..146
FT /note="ANK 2"
FT REPEAT 150..179
FT /note="ANK 3"
FT REPEAT 183..212
FT /note="ANK 4"
FT REPEAT 216..245
FT /note="ANK 5"
FT REPEAT 248..277
FT /note="ANK 6"
FT REPEAT 281..310
FT /note="ANK 7"
FT REPEAT 313..342
FT /note="ANK 8"
FT REPEAT 355..384
FT /note="ANK 9"
FT REPEAT 385..414
FT /note="ANK 10"
FT REPEAT 416..449
FT /note="ANK 11"
FT DOMAIN 521..576
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT VAR_SEQ 1..285
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_036925"
FT VAR_SEQ 60
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_046197"
FT VAR_SEQ 241..245
FT /note="KIFCL -> ANAHGQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_046198"
FT VAR_SEQ 286..296
FT /note="IHVAADRGHLL -> MLKCILKFFLR (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_036926"
FT CONFLICT 410
FT /note="A -> T (in Ref. 2; AL832472)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 587 AA; 65331 MW; 310E03BF7E618F8C CRC64;
MDNYTSDEDI DEDFDTQLII QQSLQDIYKP GTAQHAPKDE SLHSFLSADY KKIVETIEKV
GKEDALSHLT KYHSAFGEAD EIGWIPLHKA AVQLNRKILE ITLSASDPSL WEQTTHNGET
PLFLAVSSCL LENATFLLLN GCNPNAKNFE GNSPLLAAVL RDCYDMAALL INYGADVNLR
CANERTALHE AAKLGREDMV KLMLVSGAHP DPQSTYGFTP LALAAQSGHT EIMEMLLRKG
KIFCLASDSS SILLEAASGG NPDAVALLLE YGADANIPKN SGHLPIHVAA DRGHLLALKI
LIPVTDLAAI KQSGISPVHC AAAGAHPQCL ELLIQAGFDV NFMLDQRINK HYDDHRKSAL
YFAVSNSDLS SVKLLLSAGA LPNQDPVNCL QIALRMGNYE LISLLLRHGA NVNYFCRVNP
LHFPSALQYT LKDEVMLRML LNYGYDTERC FDCPHGDKVH PSYTVEGWTS TVIKDTKFCE
VITLSWLQHL SGKVVRVMLD YVDQVRICSK LKAVLQKQGI WSEIHFILTN PRSLKHLCRL
KIRKCMGRLH LRCPVFMSFL PLPNRLKAYV LYKEYDLYGQ GIFTGTW
//
