ID A6QTW8_AJECN Unreviewed; 1703 AA.
AC A6QTW8;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 24-JAN-2024, entry version 86.
DE RecName: Full=Bromo domain-containing protein {ECO:0000259|PROSITE:PS50014};
GN ORFNames=HCAG_00824 {ECO:0000313|EMBL:EDN02960.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN02960.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914}.
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DR EMBL; CH476655; EDN02960.1; -; Genomic_DNA.
DR STRING; 339724.A6QTW8; -.
DR VEuPathDB; FungiDB:HCAG_00824; -.
DR HOGENOM; CLU_000536_3_2_1; -.
DR OMA; VTPKDFM; -.
DR OrthoDB; 2783776at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd05491; Bromo_TBP7_like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR045199; ATAD2-like.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23069; AAA DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23069:SF0; TAT-BINDING HOMOLOG 7; 1.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000009297}.
FT DOMAIN 1204..1278
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1124..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1323..1600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..49
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..82
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..130
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..330
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..393
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1341..1357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1403..1475
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1483..1519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1556..1584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1703 AA; 189332 MW; 697A4EC3DBDEE95C CRC64;
MPRVSKRTLE EIVLKSDSDD GDYSDTRPRP ARKSATAKSK SKKRPTKRRR RNSMIDDDDD
DESDILTSED DISGESEFDE DDPTLERNAR GSIKRRAAKK ANYQLSSTSD DDEEDLEEEE
QEDEDEEEAD ERDMKGKSRN NDKGRTTKRL LVKFPIAAQS SNTRTTRNTR GRSASKEHPT
LTEYQGNRRI TRRTYDETED IVALTGSGRH VETVRKATRS PDALPRTRRG TAVPARAPSK
SIIDEEDYGD KVPVEPVASQ IEIMESDQHG DFEEDAPAVA ASDNIQPSAE AEENVQDKDV
EMGEEGIIPE SDQGGENEDE EEEEEEEEED APRSSRNSRA SRKQNMALET VEGASQATRR
SARKSTARNS RQPQDDGSDF EPNDDEANDE DLSESEASAA SPRKGSQQNI EEVYESSNDR
RSRLRKRQSH SQGRVESEAG ELAEELAELR PERRRRRVQN EIIYEDKPRR TRKSVDYRII
RPEITLPIEE EDAPSGSPSR RGRGGGSGWQ RTLFSTYGPF GGAGGRPPLL GGPAGTGAAG
GADSDSSDDD SGQRPMVGGM AGMTPTSGPA SGFNVAGHAF APDNAPGLSG TPANFGKVKD
RQALADADPL GIDPNVNFDS VGGLQGHIDQ LKEMVALPML YPEIFQRFHI VPPRGVLFHG
PPGTGKTLLA RALASSVSSE GRKVTFYMRK GADALSKWVG EAERQLRLLF DEARKTQPSI
IFFDEIDGLA PVRSSKQEQI HASIVSTLLA LMDGMDGRGQ VIVIGATNRP DSIDPALRRP
GRFDREFYFP LPNTEARRAI LDIHTRGWDP PLPNEIKDEL AELTKGYGGA DLRALCTEAA
LTAVQRRYPQ IYRSNEKLLI DPKKIEVSPK DFMISLKKLV PSSERSASSG ASPLPSIVEP
LLRVPLRDIK QILAEILPQK KRLTALEEAQ FEEPEDSVGF KRERMQQEFE TSRIFRPRLL
IRGNPGMGQH YIAGALLHHF EGLHVQAFDL PTLISDSTRS PEASVVQLFT EVKRHKPSVI
YIPNVQTWYE TVGQTVIATF LGLLRSLHPT DPVLLLGVLE DDGDNIDTTM MRDFFSFSKK
NRFDLHAPES LWRHEFFNTL IKYIKSAPPE FPDSENRKRR KLETLERAPL APPPPPAPPT
RQEIKAQKKK DRQTLNILKI RIQPIMDEIK KYKKFRAGVI DEAQIMYLYE EEDPNVVTTD
VPLEHRTTFR PFEKDVDKHG VPGLRETVSG KFYYNMDIVT IEKRLSNGYY KRPKDFLADI
KRIAKDARQL GDQDRQLKAN ELLSNVEVDI GNLEQSDPPL VAECEQVYLR EVERERVALE
KAKRVAGSDG AMAPPPIMNV PHGNTENSNQ SSGPVVLGEP FSNGRLPLRR EPATPPRPSH
PSTITNGYGP NKSSKDADED VTRPLTSNGS IGADGDVQMS NSDDVQPSER ENTQNSSFGP
SAQPRPPHSY TGPSQQLRQQ SGLSNLSQKG TLTPMAPGSQ PGDYANDAST TQTTTDKKQS
GPSDSNQLNT QSSIDGSTKH EYPDLNLYPD RLSGDEPLPD TQQGESGAWG TPLAGNLDFV
NSQHSLVNGS QSQSNNSKFS QLGTQPHIPP FDGSGPRTTT TPRQVRVQEL LHAEGAQQHQ
RHTFDTGKLI VDDRRLEALH HTLTQRTNGL SVEQLEQVNK SLMDCVWKMR GEWNRVEVAE
AVKQAFEEVL GDIQSMQDFA AIP
//
