ID A6QYY3_AJECN Unreviewed; 737 AA.
AC A6QYY3;
DT 21-AUG-2007, integrated into UniProtKB/TrEMBL.
DT 21-AUG-2007, sequence version 1.
DT 24-JAN-2024, entry version 67.
DE RecName: Full=XPG N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HCAG_02590 {ECO:0000313|EMBL:EDN05987.1};
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318 {ECO:0000313|EMBL:EDN05987.1, ECO:0000313|Proteomes:UP000009297};
RN [1] {ECO:0000313|Proteomes:UP000009297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24 {ECO:0000313|Proteomes:UP000009297};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family.
CC {ECO:0000256|ARBA:ARBA00024023}.
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DR EMBL; CH476656; EDN05987.1; -; Genomic_DNA.
DR AlphaFoldDB; A6QYY3; -.
DR STRING; 339724.A6QYY3; -.
DR VEuPathDB; FungiDB:HCAG_02590; -.
DR HOGENOM; CLU_378548_0_0_1; -.
DR OMA; FYQTKVI; -.
DR OrthoDB; 6876at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd09902; H3TH_MKT1; 1.
DR CDD; cd09858; PIN_MKT1; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR022039; MKT1_C.
DR InterPro; IPR037314; MKT1_H3TH.
DR InterPro; IPR022040; MKT1_N.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006084; XPG/Rad2.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11081:SF32; POST-TRANSCRIPTIONAL REGULATOR MKT1; 1.
DR Pfam; PF12246; MKT1_C; 1.
DR Pfam; PF12247; MKT1_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009297};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 328..416
FT /note="Post-transcriptional regulator MKT1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12247"
FT DOMAIN 499..734
FT /note="Post-transcriptional regulator MKT1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12246"
SQ SEQUENCE 737 AA; 83358 MW; 4321E57D1D686EE5 CRC64;
MRAIPRLRLS KYLYTMPIRA FDEWASSRAQ TLPLATLKGA VIGIDASHYL DQHLNHHATK
EPLLIALGGF PFSLRANIEK EIQVLKNQGV TCVFVFNGLN FGKREPDFTS QADSTRALEQ
AWELYDQKQA DQVVDAFSSA GSAKPEILYK FLQRILHDQG VDFLVAPYAA SAQLAYLEKG
PNRFVDAVFG PSELFLFDID KVITRLDTDI FRFTWITRQV CQDDLGRITN EQFIEFCLLL
GSRFLRTFPP FENATFPGKG VNIREAMTAY NNAGRNALVL CGQIEDEHRV NDLPYAESFK
RALMTVKHHI IMDIDGKVDP MDAENVSNDL HELIGQRLPE ELYFYMSKGI LGSQVSDWLT
SGELLIRLPL GAEDSDIYRR LQGDLLTPIR TQALCLLSNS LHRFYQTKAI NVCTWYAPKS
TRSINLKEDL PSVKESTMSW KLRSDKFPES VKQLQADSLP FAFALRALKD QEFVTKSFST
RDAPPLSSKS EILANVMWRL LQLRGYVNDK HRLTQWGQAL ETAMSSLNPT ENLEESTFIA
VELLRLGILS SKDWFANISG GPMRGTDEEK KFNLLVSQVA CIGQIRHKPI GYSGPLSRQL
LSFRSLICAV RSSLRDLVEV VLASLLLNGE ADRDRDDWAD LGLSLPFIDD NNCGLGIAVR
TYLDDLPQQS EPTSPRVRAE VKSKGKEWFQ HSDSFSGNLD LAFTLWDAAY QASQNAGKEF
KDAKLWEEAN KWLAERR
//
