ID YTM1_AJECN Reviewed; 490 AA.
AC A6R3K5;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029}; ORFNames=HCAG_04213;
OS Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=2059318;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NAm1 / WU24;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR EMBL; CH476658; EDN07703.1; -; Genomic_DNA.
DR AlphaFoldDB; A6R3K5; -.
DR SMR; A6R3K5; -.
DR STRING; 339724.A6R3K5; -.
DR VEuPathDB; FungiDB:HCAG_04213; -.
DR HOGENOM; CLU_000288_57_0_1; -.
DR OMA; YMAPQPE; -.
DR OrthoDB; 36593at2759; -.
DR Proteomes; UP000009297; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR028599; WDR12/Ytm1.
DR PANTHER; PTHR19855:SF11; RIBOSOME BIOGENESIS PROTEIN WDR12; 1.
DR PANTHER; PTHR19855; WD40 REPEAT PROTEIN 12, 37; 1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..490
FT /note="Ribosome biogenesis protein YTM1"
FT /id="PRO_0000369572"
FT REPEAT 116..168
FT /note="WD 1"
FT REPEAT 175..213
FT /note="WD 2"
FT REPEAT 224..263
FT /note="WD 3"
FT REPEAT 298..338
FT /note="WD 4"
FT REPEAT 340..379
FT /note="WD 5"
FT REPEAT 385..425
FT /note="WD 6"
FT REPEAT 449..487
FT /note="WD 7"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 23..104
FT /note="Ubiquitin-like (UBL) domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
FT REGION 255..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 52709 MW; F48CBF52CB8EBE25 CRC64;
MDGLEDGPLD ASTATSQKPQ RQVRLKLTSR HEDIALPEST GPILVPTGLR RYALSTLVNN
LLESEKPIPF EFLINGTYLR TSIDEYLTAN GISAETTLDV EYVRALVPPL HVASFLHDDW
VSAVDVLSDT SIAGSKSRVN AGQERILSAS YDGLLRMWNM SSETIALSPA AREGGHTASV
KCARMVSPSQ IISSGLDRTV RLWKYTESED GFSASITPQL ELYGHKGSVD SISMHAQSHR
ILSASADHSV GFWSTRKSEN PAAPESLLPS NTSRSSKRRK LNSSVSVPQR GPLALFKSHT
APVSAAIFDA KDPTVGYSTS WDHSLRTWDL VTGTLVDTRT ASHSLLSVSH MPELSLLASG
TSARHITLID PRASATTVSA LTLRGHTNAV VCLARDPDST YGLISGSHDG TCRIWDVRST
RTDKDGVMGE SIYSIPRKSV GGAGKRVGGE GVKVFDVCWD KSVGIVSSGE DKMIQINRGE
GVLPNGGSDR
//
